ID   SX18A_XENLA             Reviewed;         363 AA.
AC   Q90ZH8;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Transcription factor Sox-18A;
DE            Short=xSox18alpha {ECO:0000303|PubMed:12062811};
DE   AltName: Full=SRY (sex determining region Y)-box 18A;
GN   Name=sox18-a; Synonyms=sox18;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAB60829.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], DNA-BINDING, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=12062811; DOI=10.1016/s0378-1119(02)00554-1;
RA   Hasegawa M., Hiraoka Y., Hagiuda J., Ogawa M., Aiso S.;
RT   "Expression and characterization of Xenopus laevis SRY-related cDNAs,
RT   xSox17alpha1, xSox17alpha2, xSox18alpha and xSox18beta.";
RL   Gene 290:163-172(2002).
RN   [2] {ECO:0000312|EMBL:AAI69575.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcription factor. Binds to the consensus DNA
CC       sequence 5'-AACAAT-3'. Also binds 5'-CACAAT-3' and 5'-AATAAT-3' with
CC       similar affinity. {ECO:0000255, ECO:0000269|PubMed:12062811}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- TISSUE SPECIFICITY: Expressed in the adult spleen, lung, heart and
CC       kidney, and at a lower level in the adult testis, liver and brain.
CC       {ECO:0000269|PubMed:12062811}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in adults but not in embryos.
CC       {ECO:0000269|PubMed:12062811}.
CC   -!- DOMAIN: Binds target DNA via the HMG box domain.
CC       {ECO:0000250|UniProtKB:P43680}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:P35713}.
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DR   EMBL; AB052692; BAB60829.1; -; mRNA.
DR   EMBL; BC169575; AAI69575.1; -; mRNA.
DR   RefSeq; NP_001082102.1; NM_001088633.1.
DR   AlphaFoldDB; Q90ZH8; -.
DR   GeneID; 398226; -.
DR   KEGG; xla:398226; -.
DR   CTD; 398226; -.
DR   Xenbase; XB-GENE-864957; sox18.L.
DR   OMA; HNLSQPC; -.
DR   OrthoDB; 1042753at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 398226; Expressed in lung and 15 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR033392; Sox7/17/18_central.
DR   InterPro; IPR021934; Sox_C.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12067; Sox17_18_mid; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
DR   PROSITE; PS51516; SOX_C; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..363
FT                   /note="Transcription factor Sox-18A"
FT                   /id="PRO_0000375978"
FT   DOMAIN          236..362
FT                   /note="Sox C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00849"
FT   DNA_BIND        68..136
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          20..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          70..83
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P43680"
FT   REGION          94..106
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P43680"
FT   REGION          129..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..210
FT                   /note="Important for transcriptional activation"
FT                   /evidence="ECO:0000250|UniProtKB:P43680"
FT   MOTIF           308..316
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:P35713"
FT   COMPBIAS        36..50
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  40945 MW;  E696EB82D14B3F82 CRC64;
     MHRSESSYCR EETTLCQGVN STWVPPADTV PEVSLIPSSP PAPDSPAPSP KPGYGFSTCE
     EKHGDPRIRR PMNAFMVWAK DERKRLAQQN PDLHNAVLSK MLGQSWKNLT SVEKRPFVEE
     AERLRVQHLQ DHPNYKYRPR RKKQAKKLKR MDPSPLLRNE GFTRGQPMVN LSHFRNLHPL
     GGSGELESYG LPTPEMSPLD VLEPSEPAFF PPHMREDTDP VPFRTYQHGM DFSQEKTMRE
     ISLPYSSSPS HMGSFLRTPT PSAFYYKAHG GSPVCTPLGQ LSPPPEAPAL DAMDHLNQAE
     LWGDFDRNEF DQYLNMSRTQ RPGYSFPMSK LGAPRTIPCE ENSLISALSD ASTAMYYTPC
     ITG