SX18B_XENLA
ID SX18B_XENLA Reviewed; 361 AA.
AC Q90ZH7;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Transcription factor Sox-18B;
DE Short=xSox18beta {ECO:0000303|PubMed:12062811};
DE AltName: Full=SRY (sex determining region Y)-box 18B;
GN Name=sox18-b; Synonyms=sox18;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB60830.1}
RP NUCLEOTIDE SEQUENCE [MRNA], DNA-BINDING, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=12062811; DOI=10.1016/s0378-1119(02)00554-1;
RA Hasegawa M., Hiraoka Y., Hagiuda J., Ogawa M., Aiso S.;
RT "Expression and characterization of Xenopus laevis SRY-related cDNAs,
RT xSox17alpha1, xSox17alpha2, xSox18alpha and xSox18beta.";
RL Gene 290:163-172(2002).
RN [2] {ECO:0000312|EMBL:AAH72123.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen {ECO:0000312|EMBL:AAH72123.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16193513; DOI=10.1002/dvdy.20565;
RA Zhang C., Basta T., Klymkowsky M.W.;
RT "SOX7 and SOX18 are essential for cardiogenesis in Xenopus.";
RL Dev. Dyn. 234:878-891(2005).
CC -!- FUNCTION: Transcription factor. Binds to the consensus DNA sequence 5'-
CC AACAAT-3'. Also binds 5'-CACAAT-3' and 5'-AATAAT-3' but with a lower
CC affinity. Acts partially redundantly with sox7 during cardiogenesis,
CC acting indirectly through nodal-signaling to induce mesodermal,
CC organizer and endodermal tissues, which then interact to initiate
CC cardiogenesis. Also acts as an antagonist of beta-catenin signaling.
CC {ECO:0000269|PubMed:12062811, ECO:0000269|PubMed:16193513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- TISSUE SPECIFICITY: Expressed in the adult spleen, lung, heart and
CC kidney, and at a lower level in the adult testis, liver and brain.
CC {ECO:0000269|PubMed:12062811, ECO:0000269|PubMed:16193513}.
CC -!- DEVELOPMENTAL STAGE: Expressed zygotically in both embryos and adults.
CC Embryonic expression initiates during gastrulation, is down-regulated
CC between stages 15 and 23, and is then elevated up to stage 41.
CC {ECO:0000269|PubMed:12062811}.
CC -!- DOMAIN: Binds target DNA via the HMG box domain.
CC {ECO:0000250|UniProtKB:P43680}.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:P35713}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB052693; BAB60830.1; -; mRNA.
DR EMBL; BC072123; AAH72123.1; -; mRNA.
DR RefSeq; NP_001082104.1; NM_001088635.1.
DR AlphaFoldDB; Q90ZH7; -.
DR SMR; Q90ZH7; -.
DR DNASU; 398227; -.
DR GeneID; 398227; -.
DR KEGG; xla:398227; -.
DR CTD; 398227; -.
DR Xenbase; XB-GENE-6251810; sox18.S.
DR OrthoDB; 1042753at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 398227; Expressed in lung and 15 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0007507; P:heart development; IMP:UniProtKB.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IMP:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR033392; Sox7/17/18_central.
DR InterPro; IPR021934; Sox_C.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12067; Sox17_18_mid; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS51516; SOX_C; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..361
FT /note="Transcription factor Sox-18B"
FT /id="PRO_0000375979"
FT DOMAIN 234..360
FT /note="Sox C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00849"
FT DNA_BIND 66..134
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 17..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..81
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:P43680"
FT REGION 92..104
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:P43680"
FT REGION 127..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..208
FT /note="Important for transcriptional activation"
FT /evidence="ECO:0000250|UniProtKB:P43680"
FT MOTIF 306..314
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:P35713"
FT COMPBIAS 34..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..150
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 40585 MW; E862AF1F64DE5F66 CRC64;
MHRSSYCREE TTLCQGVNST WVPPADTVPE ASLTPHSPPA PDSPAPSPKP GYGYSACEEK
PGDPRIRRPM NAFMVWAKDE RKRLAQQNPD LHNAVLSKML GQSWKNLTSA EKRPFVEEAE
RLRVQHLQDH PNYKYRPRRK KQAKKLKRMD PSHHLRNEGY TGGQPMVNLS HFRELHPLGG
SGELESYGLP TPEMSPLDVL EPSEPAFFPP HMREDPDPGL FRTYQHEMDF SQEKTLREIS
LPYSTSPSHM GSFLRTPTPS AFYYKPHGGS SARTPLGQLS PPPEAPALDA MDHLNHAELW
GDFDLNEFDQ YLNMSRTQGP GYSFPMSKLG GPRTIPCEEN SLISALSDAS TAMYYTPCIT
G
