SX19A_DANRE
ID SX19A_DANRE Reviewed; 297 AA.
AC P47792; A2BEN6; Q6DC63;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Transcription factor Sox-19a;
GN Name=sox19a; Synonyms=sox19; ORFNames=si:ch211-137i24.8;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=WT; TISSUE=Embryo;
RX PubMed=7875601; DOI=10.1016/0378-1119(94)00815-a;
RA Vriz S., Lovell-Badge R.;
RT "The zebrafish Zf-Sox 19 protein: a novel member of the Sox family which
RT reveals highly conserved motifs outside of the DNA-binding domain.";
RL Gene 153:275-276(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=WT; TISSUE=Embryo;
RX PubMed=8872306; DOI=10.1016/0169-328x(96)00052-6;
RA Vriz S., Joly C., Boulekbache H., Condamine H.;
RT "Zygotic expression of the zebrafish Sox-19, an HMG box-containing gene,
RT suggests an involvement in central nervous system development.";
RL Brain Res. Mol. Brain Res. 40:221-228(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=16408288; DOI=10.1002/dvdy.20678;
RA Okuda Y., Yoda H., Uchikawa M., Furutani-Seiki M., Takeda H., Kondoh H.,
RA Kamachi Y.;
RT "Comparative genomic and expression analysis of group B1 sox genes in
RT zebrafish indicates their diversification during vertebrate evolution.";
RL Dev. Dyn. 235:811-825(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18307296; DOI=10.1021/pr700667w;
RA Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA Slijper M., Heck A.J.R.;
RT "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT analysis down to a single embryo.";
RL J. Proteome Res. 7:1555-1564(2008).
CC -!- FUNCTION: Transcriptional activator. {ECO:0000269|PubMed:16408288}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed zygotically. First detected at the mid-
CC blastula transition. Confined to the future ectoderm by the shield
CC stage, and to the presumptive neuroectoderm by the 75-80% epiboly
CC stage. From the tail bud to the 3-somite stage, expressed throughout
CC the neural plate, except in the anterior margin; strongest expression
CC in the presumptive ventral diencephalon. At the 12- to 25-somite stage,
CC expressed broadly in the central nervous system. From 24-30 hours post-
CC fertilization, restricted to the ventral diencephalon, midbrain and
CC hindbrain/anterior spinal cord region, and to the retina and lens.
CC {ECO:0000269|PubMed:16408288, ECO:0000269|PubMed:8872306}.
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DR EMBL; X79821; CAA56221.1; -; mRNA.
DR EMBL; AB242331; BAE48585.1; -; mRNA.
DR EMBL; BX119902; CAM13211.1; -; Genomic_DNA.
DR EMBL; BC078221; AAH78221.1; -; mRNA.
DR PIR; I50519; I50519.
DR RefSeq; NP_570983.2; NM_130908.2.
DR AlphaFoldDB; P47792; -.
DR SMR; P47792; -.
DR iPTMnet; P47792; -.
DR Ensembl; ENSDART00000114113; ENSDARP00000100683; ENSDARG00000010770.
DR Ensembl; ENSDART00000184159; ENSDARP00000151033; ENSDARG00000110497.
DR GeneID; 30038; -.
DR KEGG; dre:30038; -.
DR CTD; 30038; -.
DR ZFIN; ZDB-GENE-980526-102; sox19a.
DR GeneTree; ENSGT00940000165992; -.
DR HOGENOM; CLU_021123_0_0_1; -.
DR InParanoid; P47792; -.
DR OMA; STRMESY; -.
DR OrthoDB; 1161594at2759; -.
DR PhylomeDB; P47792; -.
DR TreeFam; TF351735; -.
DR Reactome; R-DRE-3769402; Deactivation of the beta-catenin transactivating complex.
DR PRO; PR:P47792; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000010770; Expressed in gastrula and 15 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IC:ZFIN.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IDA:ZFIN.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022097; SOX_fam.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..297
FT /note="Transcription factor Sox-19a"
FT /id="PRO_0000048776"
FT DNA_BIND 53..121
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
FT CONFLICT 27..33
FT /note="NGGVTHG -> KRWSDPR (in Ref. 1; CAA56221)"
FT /evidence="ECO:0000305"
FT CONFLICT 39..41
FT /note="VNS -> CQQ (in Ref. 1; CAA56221)"
FT /evidence="ECO:0000305"
FT CONFLICT 47
FT /note="S -> R (in Ref. 1; CAA56221)"
FT /evidence="ECO:0000305"
FT CONFLICT 128..129
FT /note="TK -> Q (in Ref. 1; CAA56221)"
FT /evidence="ECO:0000305"
FT CONFLICT 154
FT /note="Missing (in Ref. 1; CAA56221)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="S -> C (in Ref. 1; CAA56221)"
FT /evidence="ECO:0000305"
FT CONFLICT 220..236
FT /note="YSSTPQQPSPVMSMVKP -> IAALHSSPAQSVSHGET (in Ref. 1;
FT CAA56221)"
FT /evidence="ECO:0000305"
FT CONFLICT 243..251
FT /note="PTGAHSHQR -> SHWSPQPPA (in Ref. 1; CAA56221)"
FT /evidence="ECO:0000305"
FT CONFLICT 266
FT /note="I -> M (in Ref. 1; CAA56221)"
FT /evidence="ECO:0000305"
FT CONFLICT 280..297
FT /note="YSNIQQHYLTGTAPLTHI -> LLQHSQHSITGRRLLHTSDQKLSLPSVSGL
FT ESHRCRVKMREH (in Ref. 1; CAA56221)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 297 AA; 32785 MW; 5990122DC7A953EA CRC64;
MYSMLEHDMK SAVPPTHQSA QGMTQLNGGV THGSAKPAVN SQQQQSSDPM DKVKRPMNAF
MVWSRGQRRK MAQENPKMHN SEISKRLGAE WKLLTDAEKR PFIDEAKRLR ALHMKEYPDY
KYKPRRKTKP VLKKDNPAAK YPLSAGNLLA AAAAQGSGGS PRMDSYGWGH TGGYPGMQTD
ALGYSQQLHR YDLSALQYPS AMATAQTYMN GANSYNPMSY SSTPQQPSPV MSMVKPEQVS
HSPTGAHSHQ RGPLQGDLRD MISMYIPGGD TTDSGAQRGY SNIQQHYLTG TAPLTHI
