SX19B_DANRE
ID SX19B_DANRE Reviewed; 292 AA.
AC Q9DDD7; Q2Z1Q8;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Transcription factor Sox-19b;
DE AltName: Full=Protein sox-31;
GN Name=sox19b {ECO:0000312|EMBL:AAH56835.1};
GN Synonyms=sox31 {ECO:0000312|EMBL:CAC10492.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAC10492.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=11118886; DOI=10.1016/s0925-4773(00)00491-3;
RA Girard F., Cremazy F., Berta P., Renucci A.;
RT "Expression pattern of the Sox31 gene during zebrafish embryonic
RT development.";
RL Mech. Dev. 100:71-73(2001).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAE48586.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo {ECO:0000269|PubMed:16408288};
RX PubMed=16408288; DOI=10.1002/dvdy.20678;
RA Okuda Y., Yoda H., Uchikawa M., Furutani-Seiki M., Takeda H., Kondoh H.,
RA Kamachi Y.;
RT "Comparative genomic and expression analysis of group B1 sox genes in
RT zebrafish indicates their diversification during vertebrate evolution.";
RL Dev. Dyn. 235:811-825(2006).
RN [3] {ECO:0000312|EMBL:AAH56835.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB {ECO:0000312|EMBL:AAH56835.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18307296; DOI=10.1021/pr700667w;
RA Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA Slijper M., Heck A.J.R.;
RT "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT analysis down to a single embryo.";
RL J. Proteome Res. 7:1555-1564(2008).
CC -!- FUNCTION: Transcriptional activator. {ECO:0000269|PubMed:16408288}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Distributed throughout the blastoderm at the blastua stage but becomes
CC confined to the future ectoderm by the shield stage. Expressed in the
CC presumptive neuroectoderm at the 75-80% epiboly stage. From the tail
CC bud to the 3-somite stage, expressed throughout the neural plate,
CC except in the anterior margin. At the 12- to 25-somite stage, expressed
CC broadly in the central nervous system. {ECO:0000269|PubMed:11118886,
CC ECO:0000269|PubMed:16408288}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE48586.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ404687; CAC10492.1; -; mRNA.
DR EMBL; AB242332; BAE48586.1; ALT_INIT; mRNA.
DR EMBL; BC056835; AAH56835.1; -; mRNA.
DR RefSeq; NP_571777.1; NM_131702.1.
DR AlphaFoldDB; Q9DDD7; -.
DR SMR; Q9DDD7; -.
DR STRING; 7955.ENSDARP00000058909; -.
DR iPTMnet; Q9DDD7; -.
DR PaxDb; Q9DDD7; -.
DR GeneID; 64812; -.
DR KEGG; dre:64812; -.
DR CTD; 64812; -.
DR ZFIN; ZDB-GENE-010111-1; sox19b.
DR eggNOG; KOG0527; Eukaryota.
DR InParanoid; Q9DDD7; -.
DR OrthoDB; 1161594at2759; -.
DR PhylomeDB; Q9DDD7; -.
DR Reactome; R-DRE-3769402; Deactivation of the beta-catenin transactivating complex.
DR PRO; PR:Q9DDD7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IC:ZFIN.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0009950; P:dorsal/ventral axis specification; IMP:ZFIN.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IDA:ZFIN.
DR GO; GO:0055113; P:epiboly involved in gastrulation with mouth forming second; IMP:ZFIN.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IDA:ZFIN.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022097; SOX_fam.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..292
FT /note="Transcription factor Sox-19b"
FT /id="PRO_0000238913"
FT DNA_BIND 52..120
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 159
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
FT CONFLICT 136
FT /note="P -> S (in Ref. 2; BAE48586)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 292 AA; 32218 MW; 68FA2BDB74260B8E CRC64;
MYSMMEHELK TAGPPHTLQH SPGMSPPGSG VGNAHHVSKT ACPPGVDPMD KVKRPMNAFM
VWSRGQRRKM AQENPKMHNS EISKRLGAEW KLLTDVEKRP FIDEAKRLRA VHMKEYPDYK
YKPRRKTKAL MKKDNPVGKY PLAAGNLLAS AVAQGQGGSP RMDGYGWGHA GGYMGMQGDA
LGYPQQLHRY DLSALQYPAA QPYMNSASSY SQMSYSSSPQ QPSPVMSMVK PEPLSHSPTG
VPNHHRGAFQ GDLRDMISMY IPGGDTSESS NQRAYPGVQQ HYLGGTVPLT HI
