SX21A_DANRE
ID SX21A_DANRE Reviewed; 239 AA.
AC Q7SZS1; Q804S0; Q9PVF6; Q9YH21;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transcription factor Sox-21-A {ECO:0000303|PubMed:15037315};
DE AltName: Full=SRY-box containing gene 21a {ECO:0000312|EMBL:AAH56274.1};
GN Name=sox21a {ECO:0000312|ZFIN:ZDB-GENE-990715-6};
GN Synonyms=sox21 {ECO:0000312|EMBL:AAD00563.1,
GN ECO:0000312|ZFIN:ZDB-GENE-990715-6}, sox30 {ECO:0000303|PubMed:10370117};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAF08682.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10370117; DOI=10.1007/s004270050264;
RA De Martino S.P., Errington F., Ashworth A., Jowett T., Austin C.A.;
RT "sox30: a novel zebrafish sox gene expressed in a restricted manner at the
RT midbrain-hindbrain boundary during neurogenesis.";
RL Dev. Genes Evol. 209:357-362(1999).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAD00563.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=10559493; DOI=10.1016/s0925-4773(99)00199-9;
RA Rimini R., Beltrame M., Argenton F., Szymczak D., Cotelli F., Bianchi M.E.;
RT "Expression patterns of zebrafish sox11A, sox11B and sox21.";
RL Mech. Dev. 89:167-171(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000312|EMBL:CAD60660.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH56274.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=15037315; DOI=10.1016/j.mod.2004.01.001;
RA Argenton F., Giudici S., Deflorian G., Cimbro S., Cotelli F., Beltrame M.;
RT "Ectopic expression and knockdown of a zebrafish sox21 reveal its role as a
RT transcriptional repressor in early development.";
RL Mech. Dev. 121:131-142(2004).
RN [6] {ECO:0000305}
RP NOMENCLATURE.
RX PubMed=11071752; DOI=10.1006/dbio.2000.9883;
RA Bowles J., Schepers G., Koopman P.;
RT "Phylogeny of the SOX family of developmental transcription factors based
RT on sequence and structural indicators.";
RL Dev. Biol. 227:239-255(2000).
CC -!- FUNCTION: May function as a switch in neuronal development (By
CC similarity). Acts as a negative regulator of transcription. Plays a
CC role in dorsoventral patterning of the embryo.
CC {ECO:0000250|UniProtKB:Q9W7R5, ECO:0000269|PubMed:15037315}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- TISSUE SPECIFICITY: Expressed in all cells until gastrulation, becoming
CC restricted to the developing central nervous system later, where
CC expression is in the forebrain, midbrain and hindbrain but maximally at
CC the midbrain-hindbrain boundary. {ECO:0000269|PubMed:10370117,
CC ECO:0000269|PubMed:10559493}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expressed in oocytes and throughout embryogenesis, whereas expression
CC in adults is undetectable. {ECO:0000269|PubMed:10559493,
CC ECO:0000269|PubMed:15037315}.
CC -!- DISRUPTION PHENOTYPE: Ventralized embryos.
CC {ECO:0000269|PubMed:15037315}.
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DR EMBL; AF101266; AAF08682.1; -; mRNA.
DR EMBL; U85092; AAD00563.1; -; mRNA.
DR EMBL; AL591389; CAD60660.1; -; Genomic_DNA.
DR EMBL; BC056274; AAH56274.1; -; mRNA.
DR EMBL; BC065639; AAH65639.1; -; mRNA.
DR RefSeq; NP_571361.1; NM_131286.1.
DR AlphaFoldDB; Q7SZS1; -.
DR SMR; Q7SZS1; -.
DR STRING; 7955.ENSDARP00000049338; -.
DR PaxDb; Q7SZS1; -.
DR GeneID; 30543; -.
DR KEGG; dre:30543; -.
DR CTD; 30543; -.
DR ZFIN; ZDB-GENE-990715-6; sox21a.
DR eggNOG; KOG0527; Eukaryota.
DR InParanoid; Q7SZS1; -.
DR OrthoDB; 1335452at2759; -.
DR PhylomeDB; Q7SZS1; -.
DR TreeFam; TF351735; -.
DR Reactome; R-DRE-3769402; Deactivation of the beta-catenin transactivating complex.
DR PRO; PR:Q7SZS1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IMP:ZFIN.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IMP:ZFIN.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0048545; P:response to steroid hormone; IEP:ZFIN.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..239
FT /note="Transcription factor Sox-21-A"
FT /id="PRO_0000378071"
FT DNA_BIND 8..76
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT CONFLICT 21
FT /note="A -> V (in Ref. 3; CAD60660)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="M -> V (in Ref. 1; AAF08682 and 3; CAD60660)"
FT /evidence="ECO:0000305"
FT CONFLICT 154
FT /note="I -> M (in Ref. 2; AAD00563)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 239 AA; 26528 MW; 4D33ABAD8CD6449B CRC64;
MAKPMDHVKR PMNAFMVWSR AQRRKMALDN PKMHNSEISK RLGGEWKLLS DSEKRPFIDE
AKRLRAVHMK EHPDYKYRPR RKPKNLIKKD RYHFNVTYNL GEGDPLKSAR LSGDALSDSL
SAEKTSVAAA ATRMFFSHHL SANPYPFLDL NSKISELPPA PFPHYSVLGY PSGLPAFPGM
GVLAGAPHAH PSAGSPGHML PYNCLGWPGS GPAVPSSYVL LPGMTKAQHE PYLAYAATI
