ID   SX21B_DANRE             Reviewed;         245 AA.
AC   Q6RVD7;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Transcription factor Sox-21-B {ECO:0000303|PubMed:15037315};
DE   AltName: Full=SRY-box containing gene 21b {ECO:0000312|EMBL:CAX12766.1};
GN   Name=sox21b {ECO:0000312|ZFIN:ZDB-GENE-040429-1};
GN   ORFNames=si:ch211-247e2.1, zgc:110678;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAS47833.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=15037315; DOI=10.1016/j.mod.2004.01.001;
RA   Argenton F., Giudici S., Deflorian G., Cimbro S., Cotelli F., Beltrame M.;
RT   "Ectopic expression and knockdown of a zebrafish sox21 reveal its role as a
RT   transcriptional repressor in early development.";
RL   Mech. Dev. 121:131-142(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000312|EMBL:CAX12766.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH95366.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of transcription.
CC       {ECO:0000250|UniProtKB:Q7SZS1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- DEVELOPMENTAL STAGE: Expressed zygotically from the tailbud stage.
CC       {ECO:0000269|PubMed:15037315}.
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DR   EMBL; AY489186; AAS47833.1; -; mRNA.
DR   EMBL; CT027987; CAX12766.1; -; Genomic_DNA.
DR   EMBL; BC095366; AAH95366.1; -; mRNA.
DR   RefSeq; NP_001009888.1; NM_001009888.2.
DR   AlphaFoldDB; Q6RVD7; -.
DR   SMR; Q6RVD7; -.
DR   STRING; 7955.ENSDARP00000023480; -.
DR   PaxDb; Q6RVD7; -.
DR   Ensembl; ENSDART00000003310; ENSDARP00000023480; ENSDARG00000008540.
DR   GeneID; 406246; -.
DR   KEGG; dre:406246; -.
DR   CTD; 406246; -.
DR   ZFIN; ZDB-GENE-040429-1; sox21b.
DR   eggNOG; KOG0527; Eukaryota.
DR   GeneTree; ENSGT00940000162795; -.
DR   HOGENOM; CLU_021123_3_1_1; -.
DR   InParanoid; Q6RVD7; -.
DR   OMA; SDSIMGH; -.
DR   OrthoDB; 1335452at2759; -.
DR   PhylomeDB; Q6RVD7; -.
DR   TreeFam; TF351735; -.
DR   Reactome; R-DRE-3769402; Deactivation of the beta-catenin transactivating complex.
DR   PRO; PR:Q6RVD7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000008540; Expressed in pharyngeal gill and 28 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IMP:ZFIN.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR022097; SOX_fam.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..245
FT                   /note="Transcription factor Sox-21-B"
FT                   /id="PRO_0000378072"
FT   DNA_BIND        8..76
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   245 AA;  26801 MW;  23799A87C477ADDA CRC64;
     MSKPMDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE
     AKRLRAMHMK EHPDYKYRPR RKPKTLMKKD KFAFPVAYNL GEHEALKVGG LPAGALTESL
     MSNPDKAAAA AAAAAARVFF NPSMSANPYS FFDLGSKMTE LSPPSFSYAS PLGYPTAATA
     FSGAVGGGAH THTHSHPSPG NPGYMIPCNC AAWPSAGLQP PLAYILLPGM GKPQLEPYPA
     YAAAL