ID   SXL_CERCA               Reviewed;         348 AA.
AC   O61374;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Sex-lethal homolog;
DE   AltName: Full=CCSXL;
GN   Name=SXL;
OS   Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC   Tephritidae; Ceratitis; Ceratitis.
OX   NCBI_TaxID=7213;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A1 AND E3).
RC   STRAIN=Benakeion;
RX   PubMed=9502730; DOI=10.1242/dev.125.8.1495;
RA   Saccone G., Peluso I., Artiaco D., Giordano E., Bopp D., Polito L.C.;
RT   "The Ceratitis capitata homologue of the Drosophila sex-determining gene
RT   Sex-lethal is structurally conserved, but not sex-specifically regulated.";
RL   Development 125:1495-1500(1998).
CC   -!- FUNCTION: Unknown; apparently not involved in somatic sex
CC       determination.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=7;
CC       Name=E3;
CC         IsoId=O61374-1; Sequence=Displayed;
CC       Name=A1;
CC         IsoId=O61374-2; Sequence=VSP_005880;
CC       Name=A2;
CC         IsoId=O61374-3; Sequence=Not described;
CC       Name=A3;
CC         IsoId=O61374-4; Sequence=Not described;
CC       Name=A4;
CC         IsoId=O61374-5; Sequence=Not described;
CC       Name=E1;
CC         IsoId=O61374-6; Sequence=Not described;
CC       Name=E2;
CC         IsoId=O61374-7; Sequence=Not described;
CC   -!- DEVELOPMENTAL STAGE: Expressed in embryos of both sexes. Also expressed
CC       in the progenitor cells of the germline.
CC   -!- MISCELLANEOUS: [Isoform E3]: Embryo specific.
CC   -!- MISCELLANEOUS: [Isoform A1]: Adult specific. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform A2]: Adult specific. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform A3]: Adult specific. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform A4]: Adult specific. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform E1]: Embryo specific. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform E2]: Embryo specific. {ECO:0000305}.
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DR   EMBL; AF026145; AAC38968.1; -; mRNA.
DR   RefSeq; NP_001266336.1; NM_001279407.1. [O61374-2]
DR   AlphaFoldDB; O61374; -.
DR   SMR; O61374; -.
DR   GeneID; 101454489; -.
DR   KEGG; ccat:101454489; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0007530; P:sex determination; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR006546; Sxl.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   TIGRFAMs; TIGR01659; sex-lethal; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Nucleus; Repeat; RNA-binding.
FT   CHAIN           1..348
FT                   /note="Sex-lethal homolog"
FT                   /id="PRO_0000081965"
FT   DOMAIN          110..188
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          196..276
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          296..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         37..44
FT                   /note="Missing (in isoform A1)"
FT                   /evidence="ECO:0000303|PubMed:9502730"
FT                   /id="VSP_005880"
SQ   SEQUENCE   348 AA;  37188 MW;  CABA3DA5C2C8874A CRC64;
     MYGNMNNGGH APYGYNGYRP SGGRMWGMSH SLPSGMSRYA FSPEDTDFTS SYPGPSMNRR
     GGYNDFSGGG GGGGGTMGSM NNMVNAASTN SLNCGGGGGR DGHGGGSNGT NLIVNYLPQD
     MTDRELYALF RTIGPINTCR IMRDYKTGYS FGYAFVDFAA ETDSQRAIKS LNGITVRNKR
     LKVSYARPGG ESIKDTNLYV TNLPRTITDD QLDTIFGKYG MIVQKNILRD KLTGKPRGVA
     FVRFNKREEA QEAISALNNV IPEGASQPLT VRLAEEHGKA KAQHYMSQLG LIGGGGGGGG
     GGGGGGGGMG GPPPPPMNMG YNNMVHRGRQ NKSRFQKMHP YHNAQKFI