ID   SXL_CHRRU               Reviewed;         307 AA.
AC   O97018;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Sex-lethal homolog;
GN   Name=SXL;
OS   Chrysomya rufifacies (Hairy maggot blowfly) (Lucilia rufifacies).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Chrysomyinae; Chrysomya.
OX   NCBI_TaxID=45450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7563134; DOI=10.1007/bf00160318;
RA   Mueller-Holtkamp F.;
RT   "The Sex-lethal gene homologue in Chrysomya rufifacies is highly conserved
RT   in sequence and exon-intron organization.";
RL   J. Mol. Evol. 41:467-477(1995).
CC   -!- FUNCTION: Unknown; apparently not involved in somatic sex
CC       determination.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. The event occurs in a
CC         sex-independent manner.;
CC       Name=1;
CC         IsoId=O97018-1; Sequence=Displayed;
CC   -!- DEVELOPMENTAL STAGE: Expressed in both sexes from the onset of the
CC       cellular blastoderm formation throughout development.
CC   -!- CAUTION: It is uncertain whether Met-1 is the initiator. {ECO:0000305}.
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DR   EMBL; S79722; AAN74807.1; -; Genomic_DNA.
DR   AlphaFoldDB; O97018; -.
DR   SMR; O97018; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0007530; P:sex determination; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR006546; Sxl.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   TIGRFAMs; TIGR01659; sex-lethal; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Nucleus; Repeat; RNA-binding.
FT   CHAIN           1..307
FT                   /note="Sex-lethal homolog"
FT                   /id="PRO_0000081966"
FT   DOMAIN          85..163
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          171..251
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          285..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  33648 MW;  6F2C3DEFBF85B8FC CRC64;
     MWRMSHSLPS GMSRYAFSPQ DTDFTSSYPG PSAMNHRGGR GGGYNDFSGG GSAMGSMCNM
     APAISTNSVN SGGGDCGDNQ GCNGTNLIVN YLPQDMTDRE LYALFRTCGP INTCRIMKDY
     KTGYSFGYAF VDFASEIDAQ NAIKSLNGVT VRNKRLKVSY ARPGGESIKD TNLYVTNLPR
     TITDDELEKI FGKYGNIVQK NILRDKLTGK PRGVAFVRFN KREEAQEAIS ALNNVIPEGA
     SQPLTVRLAE EHGKMKAHHF MNQLGMGPPA APIPAAGPGY NSMVHRGRHN KNRNQKPHPY
     HNPQKFI