ID   SXL_MEGSC               Reviewed;         321 AA.
AC   O01671; O96931; Q9GVB9; Q9U536; Q9U537; Q9U5M7; Q9U5M8;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-APR-2003, sequence version 3.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Sex-lethal homolog;
GN   Name=SXL; Synonyms=SXL2;
OS   Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC   Phoridae; Megaseliini; Megaselia.
OX   NCBI_TaxID=36166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 3 AND 4), AND TISSUE SPECIFICITY.
RC   STRAIN=Wien;
RX   PubMed=10791828; DOI=10.1139/g99-132;
RA   Sievert V., Kuhn S., Paululat A., Traut W.;
RT   "Sequence conservation and expression of the sex-lethal homologue in the
RT   fly Megaselia scalaris.";
RL   Genome 43:382-390(2000).
CC   -!- FUNCTION: Unknown; apparently not involved in somatic sex
CC       determination. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC         Comment=Additional isoforms seem to exist. The event occurs in a
CC         sex-independent manner.;
CC       Name=1;
CC         IsoId=O01671-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O01671-2; Sequence=VSP_007188, VSP_007190;
CC       Name=3;
CC         IsoId=O01671-3; Sequence=VSP_007189;
CC       Name=4;
CC         IsoId=O01671-4; Sequence=VSP_007190;
CC   -!- TISSUE SPECIFICITY: Expressed in gonads and somatic tissues of both
CC       sexes. In the ovary, expressed in the last egg chamber of each
CC       ovariole. Highly expressed in nurse cells with low expression found in
CC       oocytes. Highly expressed in testis with lower expression in testis
CC       sheath and vas deferentia. {ECO:0000269|PubMed:10791828}.
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DR   EMBL; AF110846; AAF15091.1; -; Genomic_DNA.
DR   EMBL; AF110846; AAF15092.1; -; Genomic_DNA.
DR   EMBL; AJ000546; CAA04179.2; -; mRNA.
DR   EMBL; AJ245662; CAC01696.1; -; mRNA.
DR   EMBL; X98769; CAB61832.1; -; mRNA.
DR   EMBL; X98770; CAB61830.1; -; mRNA.
DR   EMBL; X98771; CAB61831.1; -; mRNA.
DR   AlphaFoldDB; O01671; -.
DR   SMR; O01671; -.
DR   STRING; 36166.O01671; -.
DR   Proteomes; UP000015102; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0007530; P:sex determination; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR006546; Sxl.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   TIGRFAMs; TIGR01659; sex-lethal; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Nucleus; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..321
FT                   /note="Sex-lethal homolog"
FT                   /id="PRO_0000081969"
FT   DOMAIN          78..156
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          164..244
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   VAR_SEQ         1..61
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_007189"
FT   VAR_SEQ         1..6
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_007188"
FT   VAR_SEQ         19..26
FT                   /note="Missing (in isoform 2 and isoform 4)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_007190"
SQ   SEQUENCE   321 AA;  35738 MW;  E2F18FC8AA0B68C0 CRC64;
     MYRGGRMWGM SHSLPSGMSS YAFSPQDTDF SSYPSTIGRQ HSQQSQRYYQ NNNCGLGSVG
     NMANSTNSLN SGTNNSGTNL IVNYLPQDMQ DRELYSLFRT IGPINTCRIM RDYKTGYSYG
     YGFVDFGSEA DALRAINNLN GITVRNKRIK VSFARPGGEQ LRDTNLYVTN LSRSITDEQL
     ETIFGKYGQI VQKNILRDKH TGTPRGVAFI RFNKREEAQE AISALNNVIP EGGTQPLTVR
     VAEEHGKSKG HVYMAPNQPP HGNMGHGNMG NMGHGNMGMA GGSGMNLNNM NAFNGMNQMV
     HRGRQKHSYQ RKIHPYNPNF L