ID   SXL_MUSDO               Reviewed;         324 AA.
AC   O17310; O17309;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Sex-lethal homolog;
GN   Name=SXL;
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SXLC1 AND SXLC2).
RC   TISSUE=Ovary;
RX   PubMed=9502729; DOI=10.1242/dev.125.8.1487;
RA   Meise M., Hilfiker-Kleiner D., Duebendorfer A., Brunner C., Noethiger R.,
RA   Bopp D.;
RT   "Sex-lethal, the master sex-determining gene in Drosophila, is not sex-
RT   specifically regulated in Musca domestica.";
RL   Development 125:1487-1494(1998).
CC   -!- FUNCTION: Unknown; apparently not involved in somatic sex
CC       determination.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=SXLC2;
CC         IsoId=O17310-1; Sequence=Displayed;
CC       Name=SXLC1;
CC         IsoId=O17310-2; Sequence=VSP_005891;
CC   -!- TISSUE SPECIFICITY: Expressed in somatic cells of both sexes throughout
CC       development, but not in the pole cells which are the progenitors of the
CC       germline.
CC   -!- DEVELOPMENTAL STAGE: First appears in blastoderm embryos after onset of
CC       cellularisation.
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DR   EMBL; AF025689; AAB81985.1; -; mRNA.
DR   EMBL; AF025690; AAB81986.1; -; mRNA.
DR   RefSeq; NP_001274464.1; NM_001287535.1. [O17310-1]
DR   RefSeq; XP_005177313.1; XM_005177256.3. [O17310-2]
DR   AlphaFoldDB; O17310; -.
DR   SMR; O17310; -.
DR   STRING; 7370.XP_005177313.1; -.
DR   GeneID; 101898639; -.
DR   KEGG; mde:101898639; -.
DR   CTD; 3772180; -.
DR   VEuPathDB; VectorBase:MDOA004484; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   Proteomes; UP000095301; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0007530; P:sex determination; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR006546; Sxl.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   TIGRFAMs; TIGR01659; sex-lethal; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Nucleus; Repeat; RNA-binding.
FT   CHAIN           1..324
FT                   /note="Sex-lethal homolog"
FT                   /id="PRO_0000081970"
FT   DOMAIN          102..180
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          188..268
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   VAR_SEQ         304..324
FT                   /note="GRQNKMRNHKVHPYHNPQKFI -> AYNYSGLLDGFYRNKSYHYPYL (in
FT                   isoform SXLC1)"
FT                   /evidence="ECO:0000303|PubMed:9502729"
FT                   /id="VSP_005891"
FT   CONFLICT        8..9
FT                   /note="NV -> GT (in Ref. 1; AAB81985)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   324 AA;  35755 MW;  A665216EEA5CF767 CRC64;
     MYGQNVRNVS YYPPYGYNGY KQSGERMWRM SHSLPSGMDT DFTSSYPGPS AMNPRGRGGY
     NDFSGGGSAM GSMCNMAPAQ STNSLNSGGD GGGGDTQAVN GTNLIVNYLP QDMTDRELYA
     LFRTCGPINT CRIMKDYKTG YSFGYAFVDF ASEIDAQNAI KTVNGITVRN KRLKVSYARP
     GGESIKDTNL YVTNLPRTIT DDELEKIFGK YGNIVQKNIL RDKLTGRPRG VAFVRFNKRE
     EAQEAISALN NVIPEGASQP LTVRLAEEHG KMKAHHFMNQ LGMGPPAAPI PAAGPGYNNM
     VHRGRQNKMR NHKVHPYHNP QKFI