ID   SXT1_TAKPA              Reviewed;         391 AA.
AC   Q90WJ7;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2003, sequence version 2.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Saxitoxin and tetrodotoxin-binding protein 1;
DE   Flags: Precursor;
GN   Name=psbp1; Synonyms=pstbp1;
OS   Takifugu pardalis (Panther puffer) (Tetraodon pardalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=98921 {ECO:0000312|EMBL:BAB55581.2};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-44; 116-140 AND 323-367,
RP   FUNCTION, SUBUNIT, AND GLYCOSYLATION.
RC   TISSUE=Liver;
RX   PubMed=11722582; DOI=10.1046/j.0014-2956.2001.02547.x;
RA   Yotsu-Yamashita M., Sugimoto A., Terakawa T., Shoji Y., Miyazawa T.,
RA   Yasumoto T.;
RT   "Purification, characterization, and cDNA cloning of a novel soluble
RT   saxitoxin and tetrodotoxin binding protein from plasma of the puffer fish,
RT   Fugu pardalis.";
RL   Eur. J. Biochem. 268:5937-5946(2001).
CC   -!- FUNCTION: Binds both saxitoxin and tetradotoxin. May play a role in
CC       toxin accumulation and/or excretion. {ECO:0000269|PubMed:11722582,
CC       ECO:0000303|PubMed:11722582}.
CC   -!- SUBUNIT: Homodimer or heterodimer of PSTBP1 and PSTBP2.
CC       {ECO:0000269|PubMed:11722582}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:11722582}.
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DR   EMBL; AB055707; BAB55581.2; -; mRNA.
DR   AlphaFoldDB; Q90WJ7; -.
DR   SMR; Q90WJ7; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:CACAO.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019534; F:toxin transmembrane transporter activity; NAS:UniProtKB.
DR   GO; GO:0009636; P:response to toxic substance; NAS:UniProtKB.
DR   Gene3D; 2.40.128.20; -; 2.
DR   InterPro; IPR012674; Calycin.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Repeat; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000269|PubMed:11722582"
FT   CHAIN           21..391
FT                   /note="Saxitoxin and tetrodotoxin-binding protein 1"
FT                   /id="PRO_0000022459"
FT   REPEAT          24..202
FT                   /note="1"
FT   REPEAT          203..391
FT                   /note="2"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        63
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        97
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        234
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        268
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        277
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        307
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        253..254
FT                   /note="Missing (in Ref. 1; Fig.7)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   391 AA;  44067 MW;  CE7F160043ED016A CRC64;
     MGAVPGVVLL LMLAVLGIRA APAPEECHKL TKPVTKADVQ SVSGDWVLVW SVANTTERWI
     CENLTSSYVE FKLHSDIIEY TERNLFLGNS CISFYSNLSA STEKQQQFSL NNLQMEEKGV
     VRPFNDNGTV KFFETCVDCL SMEYSGDIGR FLLIYRRDGV HQNVEVLKAA QDESQKLAEC
     LGFSIDEPFI YDGVSDFCHK KSPEECHKLT KPVTKADVQS VSGDWVLVWS IDENSTISDD
     WKKLKTSYVE QRVDSGVIRF TERNMLKNNS CMTFKTNMTA GPESQNTFIY TSGKMEENGV
     VTVLDENGTV KFFETCADCL SMEYSGFFGH FLLIYRRDGV HQNVEVLKAA QDESQKLAEC
     LGFSIDEPFI YDGVSDFCHK KSSPEVKPEQ D