SXT2_TAKPA
ID SXT2_TAKPA Reviewed; 391 AA.
AC Q90WJ9;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Saxitoxin and tetrodotoxin-binding protein 2;
DE Flags: Precursor;
GN Name=psbp2; Synonyms=pstbp2;
OS Takifugu pardalis (Panther puffer) (Tetraodon pardalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=98921;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-44 AND 116-140,
RP FUNCTION, SUBUNIT, AND GLYCOSYLATION.
RC TISSUE=Liver;
RX PubMed=11722582; DOI=10.1046/j.0014-2956.2001.02547.x;
RA Yotsu-Yamashita M., Sugimoto A., Terakawa T., Shoji Y., Miyazawa T.,
RA Yasumoto T.;
RT "Purification, characterization, and cDNA cloning of a novel soluble
RT saxitoxin and tetrodotoxin binding protein from plasma of the puffer fish,
RT Fugu pardalis.";
RL Eur. J. Biochem. 268:5937-5946(2001).
CC -!- FUNCTION: Binds both saxitoxin and tetradotoxin. May play a role in
CC toxin accumulation and/or excretion. {ECO:0000269|PubMed:11722582}.
CC -!- SUBUNIT: Homodimer or heterodimer of PSTBP1 and PSTBP2.
CC {ECO:0000269|PubMed:11722582}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:11722582}.
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DR EMBL; AB037569; BAB55583.1; -; mRNA.
DR AlphaFoldDB; Q90WJ9; -.
DR SMR; Q90WJ9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.40.128.20; -; 2.
DR InterPro; IPR012674; Calycin.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Repeat; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:11722582"
FT CHAIN 21..391
FT /note="Saxitoxin and tetrodotoxin-binding protein 2"
FT /id="PRO_0000022460"
FT REPEAT 24..202
FT /note="1"
FT REPEAT 203..391
FT /note="2"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 234
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 391 AA; 43886 MW; 6863450D7C040365 CRC64;
MGAVPGVVLL LMLAVLGIRA APAPEECHKL TKPVLKADVQ NVSGDWVLVW SVANTTERWI
CENLTSSYVE FKLHSDIIEY TERNLFLGNS CISFYSNLSA STEKQQQFSL NNLQMEEKGV
VRPFNDNGTV KFFETCVDCL SMEYSGDIGR FLLIYRRDGV HQNVEVLKAA RDESQKLAEC
LGFSIDEPFI YDGVSDFCHK KSPEECHKLT KPVTKADVQS VSGDWVLVWS VAENISTSNE
WTKLKSSHVE LRIHSGVIVL NERNMLKNNS CMTFKTNMTA GPESQNTFIY TSGKMEENGV
DKELDENGTV KFFETCADCL SIDYSGLFGH VLFVYRRDGV HQNVEVLKAA QDESQKLAEC
LGFSIGEPFI YDGVSDFCHK KSSPEVKPEQ D