SY124_ARATH
ID SY124_ARATH Reviewed; 303 AA.
AC O64791; Q1PFI1;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 140.
DE RecName: Full=Syntaxin-124;
DE Short=AtSYP124;
GN Name=SYP124; OrderedLocusNames=At1g61290; ORFNames=T1F9.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
CC -!- FUNCTION: Vesicle trafficking protein that functions in the secretory
CC pathway. {ECO:0000250}.
CC -!- SUBUNIT: Part of the t-SNARE complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type IV
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR EMBL; AC004255; AAC13912.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33817.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60085.1; -; Genomic_DNA.
DR EMBL; DQ446382; ABE65730.1; -; mRNA.
DR PIR; G96638; G96638.
DR RefSeq; NP_001319282.1; NM_001333948.1.
DR RefSeq; NP_176324.1; NM_104810.3.
DR AlphaFoldDB; O64791; -.
DR SMR; O64791; -.
DR STRING; 3702.AT1G61290.1; -.
DR PaxDb; O64791; -.
DR PRIDE; O64791; -.
DR ProteomicsDB; 226540; -.
DR EnsemblPlants; AT1G61290.1; AT1G61290.1; AT1G61290.
DR EnsemblPlants; AT1G61290.2; AT1G61290.2; AT1G61290.
DR GeneID; 842423; -.
DR Gramene; AT1G61290.1; AT1G61290.1; AT1G61290.
DR Gramene; AT1G61290.2; AT1G61290.2; AT1G61290.
DR KEGG; ath:AT1G61290; -.
DR Araport; AT1G61290; -.
DR TAIR; locus:2197749; AT1G61290.
DR eggNOG; KOG0810; Eukaryota.
DR HOGENOM; CLU_042423_1_1_1; -.
DR InParanoid; O64791; -.
DR OMA; IESNPIH; -.
DR OrthoDB; 1033833at2759; -.
DR PhylomeDB; O64791; -.
DR PRO; PR:O64791; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O64791; baseline and differential.
DR Genevisible; O64791; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0030133; C:transport vesicle; IDA:TAIR.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0009860; P:pollen tube growth; IDA:TAIR.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR CDD; cd00179; SynN; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; PTHR19957; 1.
DR Pfam; PF05739; SNARE; 1.
DR Pfam; PF00804; Syntaxin; 1.
DR SMART; SM00503; SynN; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; SSF47661; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Coiled coil; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..303
FT /note="Syntaxin-124"
FT /id="PRO_0000210249"
FT TOPO_DOM 1..279
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..303
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT DOMAIN 203..265
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT REGION 107..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 31..112
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9SVC2"
SQ SEQUENCE 303 AA; 34468 MW; B02A2592CA145210 CRC64;
MNDLFSSSFK KYTDLKQQAQ MDDIESGKET MNLDKFFEDV ENVKDNMKGV ETLYKSLQDS
NEECKTVHNA KKVKELRAKM DGDVAQVLKR VKMIKQKLEA LEKANANSRN VSGCGPGSST
DRTRTSVVSG LGKKLKDLMD SFQGLRARMN AEYKETVERR YFTITGEQAD EQTIENLISS
GESENFLQKA IQEQGRGQIL DTISEIQERH DAVKEIEKNL IELHQVFLDM AALVESQGQQ
LNDIESHVSK ASSFVRRGTD QLQDAREYQK SSRKWTCYAI LLFIVVFALL LIPALPHIML
MLK
