SY14L_HUMAN
ID SY14L_HUMAN Reviewed; 188 AA.
AC Q58G82; A2RTZ8; Q9BQR7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Putative synaptotagmin-14-like protein {ECO:0000305};
DE AltName: Full=Synaptotagmin XIV protein pseudogene 1 {ECO:0000312|HGNC:HGNC:33429};
DE AltName: Full=Synaptotagmin XIV-derived protein {ECO:0000303|PubMed:16376304};
DE AltName: Full=Synaptotagmin XIV-like protein {ECO:0000303|PubMed:11543631};
GN Name=SYT14P1 {ECO:0000312|HGNC:HGNC:33429};
GN Synonyms=SYT14L {ECO:0000303|PubMed:11543631}, SYT14LP1,
GN SYTDEP {ECO:0000303|PubMed:16376304, ECO:0000312|EMBL:AAX40990.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAX40990.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP INDUCTION, AND VARIANT MET-97.
RX PubMed=16376304; DOI=10.1016/j.bbrc.2005.11.184;
RA Herrero-Turrion M.J., Fukuda M., Mollinedo F.;
RT "Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-
RT related gene.";
RL Biochem. Biophys. Res. Commun. 340:386-394(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305, ECO:0000312|EMBL:CAC33890.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 47-188, AND TISSUE SPECIFICITY.
RC TISSUE=Brain {ECO:0000312|EMBL:CAC33890.1};
RX PubMed=11543631; DOI=10.1006/geno.2001.6619;
RA Craxton M.A.;
RT "Genomic analysis of synaptotagmin genes.";
RL Genomics 77:43-49(2001).
RN [6]
RP FUNCTION, DOMAIN, AND TISSUE SPECIFICITY.
RX PubMed=23999003; DOI=10.1016/j.jdermsci.2013.07.010;
RA Yoo J.C., Lim T.Y., Park J.S., Hah Y.S., Park N., Hong S.G., Park J.Y.,
RA Yoon T.J.;
RT "SYT14L, especially its C2 domain, is involved in regulating melanocyte
RT differentiation.";
RL J. Dermatol. Sci. 72:246-251(2013).
CC -!- FUNCTION: Plays a role in melanocyte differentiation; enhances dendrite
CC outgrowth, melanin content and tyrosinase activity through the
CC modulation of ERK and/or CREB pathways (PubMed:23999003).
CC {ECO:0000269|PubMed:16376304, ECO:0000269|PubMed:23999003}.
CC -!- TISSUE SPECIFICITY: Expressed in mature peripheral blood neutrophils
CC (at protein level) (PubMed:16376304). Expressed in heart, pancreas,
CC liver and skeletal muscle (PubMed:11543631). Expressed in umbilical
CC vein endothelial cells and melanocytes (PubMed:23999003).
CC {ECO:0000269|PubMed:11543631, ECO:0000269|PubMed:16376304,
CC ECO:0000269|PubMed:23999003}.
CC -!- DEVELOPMENTAL STAGE: Up-regulated during neutrophil differentiation
CC (PubMed:16376304). {ECO:0000269|PubMed:16376304}.
CC -!- INDUCTION: Up-regulated during neutrophil differentiation
CC (PubMed:16376304). {ECO:0000269|PubMed:16376304}.
CC -!- DOMAIN: The C2 domain is necessary and sufficient to promote melanocyte
CC dendrite outgrowth (PubMed:23999003). {ECO:0000269|PubMed:23999003}.
CC -!- SIMILARITY: Belongs to the synaptotagmin family. {ECO:0000255}.
CC -!- CAUTION: Could be the product of a pseudogene. Encoded by an expressed
CC retrotransposed copy of the SYT14 locus into an intron of TMPRSS11F.
CC {ECO:0000305}.
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DR EMBL; AY954513; AAX40990.1; -; mRNA.
DR EMBL; AC096727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471057; EAX05567.1; -; Genomic_DNA.
DR EMBL; BC132697; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AJ303368; CAC33890.1; -; mRNA.
DR AlphaFoldDB; Q58G82; -.
DR SMR; Q58G82; -.
DR BioMuta; HGNC:33429; -.
DR DMDM; 166979750; -.
DR MaxQB; Q58G82; -.
DR PRIDE; Q58G82; -.
DR GeneCards; SYT14P1; -.
DR HGNC; HGNC:33429; SYT14P1.
DR MIM; 610892; gene.
DR neXtProt; NX_Q58G82; -.
DR InParanoid; Q58G82; -.
DR PhylomeDB; Q58G82; -.
DR PathwayCommons; Q58G82; -.
DR Pharos; Q58G82; Tbio.
DR PRO; PR:Q58G82; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q58G82; protein.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0032793; P:positive regulation of CREB transcription factor activity; IMP:UniProtKB.
DR GO; GO:1903861; P:positive regulation of dendrite extension; IMP:UniProtKB.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR028696; SYT14.
DR InterPro; IPR043541; SYT14/14L/16.
DR PANTHER; PTHR46129; PTHR46129; 1.
DR PANTHER; PTHR46129:SF3; PTHR46129:SF3; 1.
DR Pfam; PF00168; C2; 1.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
PE 5: Uncertain;
KW Differentiation; Reference proteome.
FT CHAIN 1..188
FT /note="Putative synaptotagmin-14-like protein"
FT /id="PRO_0000318116"
FT DOMAIN 49..182
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT VARIANT 97
FT /note="T -> M (in dbSNP:rs3819257)"
FT /evidence="ECO:0000269|PubMed:16376304"
FT /id="VAR_038691"
SQ SEQUENCE 188 AA; 21436 MW; FF3481AFDB726C85 CRC64;
MLEGFQILVQ NTVQGTIHKI KCVCDSQMSV SEMSCSESTS ACQSLEDGSV PEILISLLYN
ATNGRLSAEV IKGSHLKNWA ANRPPNTYVK LTLRKSTDQE MSKCKISIRR GRPNPVYKET
FVFKVTLFQL SHVTLMLSVY NKSSMRRKMI GWIYLGLNSS GEELNHWTEM KESKGRQVRR
WQALLESR
