ID   ABKA_DICDI              Reviewed;         565 AA.
AC   Q54IH6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Probable serine/threonine-protein kinase abkA;
DE            EC=2.7.11.-;
GN   Name=abkA; Synonyms=adckA; ORFNames=DDB_G0288749;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA   Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT   "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT   model organism.";
RL   PLoS Genet. 2:E38-E38(2006).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC       kinase family. {ECO:0000305}.
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DR   EMBL; AAFI02000122; EAL63067.1; -; Genomic_DNA.
DR   RefSeq; XP_636572.1; XM_631480.1.
DR   AlphaFoldDB; Q54IH6; -.
DR   SMR; Q54IH6; -.
DR   STRING; 44689.DDB0216427; -.
DR   PaxDb; Q54IH6; -.
DR   PRIDE; Q54IH6; -.
DR   EnsemblProtists; EAL63067; EAL63067; DDB_G0288749.
DR   GeneID; 8626786; -.
DR   KEGG; ddi:DDB_G0288749; -.
DR   dictyBase; DDB_G0288749; abkA.
DR   eggNOG; KOG1234; Eukaryota.
DR   HOGENOM; CLU_006533_9_0_1; -.
DR   InParanoid; Q54IH6; -.
DR   OMA; QVERVMN; -.
DR   PhylomeDB; Q54IH6; -.
DR   PRO; PR:Q54IH6; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IBA:GO_Central.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IBA:GO_Central.
DR   CDD; cd13970; ABC1_ADCK3; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR034646; ADCK3_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF03109; ABC1; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Kinase; Nucleotide-binding; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..565
FT                   /note="Probable serine/threonine-protein kinase abkA"
FT                   /id="PRO_0000367576"
FT   DOMAIN          231..565
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   COILED          44..77
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        401
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         237..245
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         259
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   565 AA;  64525 MW;  2AB2DD3CDF5EA3F4 CRC64;
     MGGRLNDLIQ VAYGGKNVIL SMMKNKTRQT SSVFINNLNS LNNNNNNISL KDKFKDLKDL
     KDNLNEKKIN NDNDDDDEDN LIFDEKKDFL NENKNPELNY IKSKGHKIPS SQTSRFWEFT
     KLAVGVGAGF LGEKTKRTID SSSSSSSPSS SYSAIFTDTN AERMAESFSR MRGAALKIGQ
     VLSIQDESFL PPKFVEILDR VRKNANPIPL EQLYNTMSNE LGENWRSKFQ LFQDDPIAAA
     SIGQVHRAIT LDGKEVAVKV QYPGVADSIT SDIKNLSSLL KMIVPETAYI EKSLESARSE
     LLLETDYLNE ASNQLKFKSL LESSINSGTN GSFKYLKDLY VPNVIMELTT KRILTTEFVH
     GTSIDKITIE NHNQETRDWI SKNILSLCLA ELFEFNFMQV DPNWTNFVVD FENKRINLLD
     FGACRNYKSE FLFNYLKSIE GGVNRDINQI LEYSLKLGYL TGDENKQMND AQAKSILILS
     EPFSKLYYKE NNLKTYPFNE KQIAKRISQL IPTMLKNRLK PPPEETYSLH RKLSGCYLVC
     SKLKSNINST LIFNHFKNIF YKNYK