ID   ABKB_DICDI              Reviewed;         668 AA.
AC   Q54TR5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Probable serine/threonine-protein kinase abkB;
DE            EC=2.7.11.-;
GN   Name=abkB; Synonyms=adckB1; ORFNames=DDB_G0281799;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA   Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT   "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT   model organism.";
RL   PLoS Genet. 2:E38-E38(2006).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC       kinase family. {ECO:0000305}.
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DR   EMBL; AAFI02000042; EAL66661.1; -; Genomic_DNA.
DR   RefSeq; XP_640526.1; XM_635434.1.
DR   AlphaFoldDB; Q54TR5; -.
DR   SMR; Q54TR5; -.
DR   STRING; 44689.DDB0229418; -.
DR   PaxDb; Q54TR5; -.
DR   EnsemblProtists; EAL66661; EAL66661; DDB_G0281799.
DR   GeneID; 8623136; -.
DR   KEGG; ddi:DDB_G0281799; -.
DR   dictyBase; DDB_G0281799; abkB.
DR   eggNOG; KOG1235; Eukaryota.
DR   HOGENOM; CLU_006533_2_0_1; -.
DR   InParanoid; Q54TR5; -.
DR   OMA; CIFNIEI; -.
DR   PhylomeDB; Q54TR5; -.
DR   PRO; PR:Q54TR5; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0032592; C:integral component of mitochondrial membrane; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd13969; ADCK1-like; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR045307; ADCK1_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF03109; ABC1; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Kinase; Nucleotide-binding; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..668
FT                   /note="Probable serine/threonine-protein kinase abkB"
FT                   /id="PRO_0000367577"
FT   DOMAIN          314..668
FT                   /note="Protein kinase"
FT   REGION          88..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          131..163
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        478
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         320..328
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         346
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   668 AA;  77042 MW;  32EB77AFCBCD3157 CRC64;
     MNQIHSTILK KGILNIKPQI RNITKCTNTI NYNNNNINNR YFTSINKNKN IENLLQQQPQ
     QQPQQQLQQQ PILFVQNQNN INYFKREYTN IGGTSPNRQS VPENSTTKTT ATATVETDNV
     VNSSTTFTLP KEVEEEIIDK NERGKEQEQE NKQQKEQKDD NKSGSIFSIK GWLTISILSV
     LALGTKLVID PPQNIDKLDL AFIRNLRVLY AGFKITFYYK YYLMGLNRGD EGFAENIQIA
     HKLAAKAMVD LCYQNKGIFI KVAQIIASLD HILPQEYIKS LSIFQDHAPF VTFEEVEKLF
     KIETGKHPDD MFIDFERLPI NSASLAQVHK AKLKLENDEI IEVAVKVQYP GLMNKFQKDM
     DSLDNVLTYI TLFFPSFQFS WILGEASSCL SQELDFVNEA KNSEKMKQLF IGNQQLSIPK
     VYWNHTTKRI LTMEFIHGVR IDNREGLDKL GIDLKELYYL FSDIFAQQIF VHGFLHSDPH
     PGNLLVRKTP NGKPDLVLLD HGLYKKIDEN VRLDFCHLWK SLCLGDAKTS EFYAERLGAG
     IYAKHLGILL NLNPSKSREN LRNMKRELKD QTLVVINEIL KNLPKEILLV LKTNNLIRQI
     TTHFGIENGF LNMAKTCIKG IYTGNDIITK LKYYLTLCIF NIEIKVIDFI KKRKPPQVEI
     PSTYHHHH