ID   ABKC_DICDI              Reviewed;         689 AA.
AC   Q55G83;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Probable serine/threonine-protein kinase abkC;
DE            EC=2.7.11.-;
GN   Name=abkC; Synonyms=adckC; ORFNames=DDB_G0267774;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA   Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT   "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT   model organism.";
RL   PLoS Genet. 2:E38-E38(2006).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC       kinase family. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73340.1; -; Genomic_DNA.
DR   RefSeq; XP_647300.1; XM_642208.1.
DR   AlphaFoldDB; Q55G83; -.
DR   STRING; 44689.DDB0220789; -.
DR   PaxDb; Q55G83; -.
DR   EnsemblProtists; EAL73340; EAL73340; DDB_G0267774.
DR   GeneID; 8616109; -.
DR   KEGG; ddi:DDB_G0267774; -.
DR   dictyBase; DDB_G0267774; abkC.
DR   eggNOG; KOG1236; Eukaryota.
DR   HOGENOM; CLU_006533_6_1_1; -.
DR   InParanoid; Q55G83; -.
DR   OMA; RRDLKIM; -.
DR   PhylomeDB; Q55G83; -.
DR   PRO; PR:Q55G83; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd13971; ADCK2-like; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR044095; ADCK2_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF03109; ABC1; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Kinase; Nucleotide-binding; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..689
FT                   /note="Probable serine/threonine-protein kinase abkC"
FT                   /id="PRO_0000367578"
FT   DOMAIN          257..689
FT                   /note="Protein kinase"
FT   REGION          42..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          652..689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        652..683
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        417
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         263..271
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         285
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   689 AA;  79409 MW;  73FBD58BD9CBC0ED CRC64;
     MSNKQIFLKF KSGEIILNNF NKYTDSISSK LLFYQNIKNQ ENNSGNENYK NFNYNYKNKN
     NYNNNNNNNN SNSSSNNNGS NNNIKFNSLF ISSIYLYNNN NSNNNDLKND KNDNSIGNIN
     KIIKPKIEIQ DLLNPFEAIK EIVGNKEDEE INLVKIGIRV LELGLILLPS VLTFPCCFIP
     GVKELWWQLL LETIQFSGTC WIKFGQWIST RPDLFPDLLI EKFSQLHSQC PSHSFQFTNE
     SIENSFNGKS IKDLFLWFDE EPMASGSVAQ VHKALTMDGK VAVVKVLHPN VKSNIKRDFF
     IIYSLIWAFS HIPEMKWLSL PESILEFGKS MMKQADLELE ASHLNRFNSN FKYNSEVIFP
     KPLYPLVSKE VLVESFEPGS PIMDFIKKND HHNPTLAKIG LSAYMQMMLV DNFVHADLHP
     GNVLVRTSDD DNFKSIDNNY FKKYNNDNDQ QQQQQYNLPF KRKLYDTIEK SHKKFDSMLG
     GIQLKSIDFK EHQKSSPKLI FLDVGLVTQL GQQDKDHFIE LFTEIVNGNG KEGAELLIRY
     AREAKCTEEE MYQFKERMGT LFNQVQNSKL SEVHVGQFMS EILGLVREYH VKIESNFATL
     VMGTIVLEGL GKQLDPSLGL LKAAIPFLLK SQVFSFSNFI KDFFLKSKTS KKQLNNDNNN
     NNNNNNNNKN NNDNNNKNNN NKNNNEKNK