ABKD_DICDI
ID ABKD_DICDI Reviewed; 695 AA.
AC Q54P00;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Probable serine/threonine-protein kinase abkD;
DE EC=2.7.11.-;
GN Name=abkD; Synonyms=adckB2; ORFNames=DDB_G0284897;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT model organism.";
RL PLoS Genet. 2:E38-E38(2006).
RN [3]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA Ivens A., Martinez J.L., Escalante R.;
RT "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT and specific effects from PAO1 and PA14 strains.";
RL BMC Microbiol. 8:109-109(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC kinase family. {ECO:0000305}.
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DR EMBL; AAFI02000073; EAL64912.1; -; Genomic_DNA.
DR RefSeq; XP_639917.1; XM_634825.1.
DR AlphaFoldDB; Q54P00; -.
DR SMR; Q54P00; -.
DR STRING; 44689.DDB0216431; -.
DR PaxDb; Q54P00; -.
DR PRIDE; Q54P00; -.
DR EnsemblProtists; EAL64912; EAL64912; DDB_G0284897.
DR GeneID; 8624829; -.
DR KEGG; ddi:DDB_G0284897; -.
DR dictyBase; DDB_G0284897; abkD.
DR eggNOG; KOG1235; Eukaryota.
DR HOGENOM; CLU_006533_2_6_1; -.
DR InParanoid; Q54P00; -.
DR OMA; VQGSNRF; -.
DR PhylomeDB; Q54P00; -.
DR PRO; PR:Q54P00; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0032592; C:integral component of mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0099138; P:altruistic, chimeric sorocarp development; IMP:dictyBase.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13969; ADCK1-like; 1.
DR InterPro; IPR004147; ABC1_dom.
DR InterPro; IPR045307; ADCK1_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF03109; ABC1; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Kinase; Membrane; Nucleotide-binding;
KW Reference proteome; Serine/threonine-protein kinase; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..695
FT /note="Probable serine/threonine-protein kinase abkD"
FT /id="PRO_0000367579"
FT TRANSMEM 177..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 317..695
FT /note="Protein kinase"
FT REGION 105..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 118..150
FT /evidence="ECO:0000255"
FT COMPBIAS 105..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 477
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 323..331
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 345
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 695 AA; 80336 MW; A3A6B0E561A137F8 CRC64;
MKILKFSLLS KLKHKDFIVT SFRNNIINSI KNNNTNNNGL LKFSNNKYNF LNNNNNNNNN
NVNKINNVYY INNNFKNVME NKIKPSSIQF FSSLSNKYNL NSFTTTKPQP CQAKPPSSKQ
QQQQQQQQQQ QQQQQQQQQS KKKTSKDRLR DILKKTVITP QEFLNVLQRF AKNYKKTIAS
ILAAIALIIY SYETPDSYFG SMMNVIVRFY RAMKCATKIM INYKILSYTP EKSSEYLEKS
KICHQESADL ILDLCLTNGG LYIKAGQYIA SLNHILPIQY TKTLSVLQDQ APWRDFYEVE
SVFLKDLGNA PNHYFSDFDR LPIAAASLAQ VHRAITKEGE EVAVKVQYVD LQRNFDGDIF
THNVLLTLVN MAFPDFEFNW MAEEMKNVLI KELDFSQEAD NAERAAQDLS SNNNAYIPKV
FRPYSSKRIL TTEFIHGCKI NNVQAIRSMG LSEKTVSQRF MEIMCEQIFI HAFVHVDPHA
GNVLVRQHPN HPNQPQIVLL DHGLYREYDE EFRLNFCNLY KNLVLCNNKK VEKYSKALGV
QNWKLFSTMI LMRNFEGSSV GLSNSISSEE LEKLLSGAIE RLKDINLLMK AMPRHLLLIL
RNNNLLRSIN MELGSPVNRF SIMARYAAKG LNSNSSKNSG IIRLVKSVEE KVSLEVMLKG
YELYYYFVNR ILSILIRLHI INPEKLIKDQ MKKLG
