SYB1_CAEBR
ID SYB1_CAEBR Reviewed; 108 AA.
AC Q60WU2; A8XUI1;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Synaptobrevin-1;
DE AltName: Full=Synaptobrevin-related protein 1;
GN Name=snb-1 {ECO:0000250|UniProtKB:O02495}; ORFNames=CBG18986;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Involved in the targeting and/or fusion of transport vesicles
CC to their target membrane. Acts in neuronal exocytosis of synaptic
CC transmission. Likely to have a role in cholinergic transmisson.
CC Required for viability, coordinated movement and M3 pharynx motor
CC neuron function (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the SNARE core complex containing CBG09569/SNAP25,
CC snb-1/VAMP2 and CBG03570/STX1A. This complex binds to cpx-1/CPLX1 (By
CC similarity). {ECO:0000250|UniProtKB:P63045}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000250|UniProtKB:O02495,
CC ECO:0000250|UniProtKB:P63045}; Single-pass type IV membrane protein
CC {ECO:0000250|UniProtKB:O02495, ECO:0000250|UniProtKB:P63045}. Cell
CC membrane {ECO:0000250|UniProtKB:O02495, ECO:0000250|UniProtKB:P63045}.
CC Synapse, synaptosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000255}.
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DR EMBL; HE601047; CAP36306.1; -; Genomic_DNA.
DR RefSeq; XP_002637298.1; XM_002637252.1.
DR AlphaFoldDB; Q60WU2; -.
DR SMR; Q60WU2; -.
DR STRING; 6238.CBG18986; -.
DR EnsemblMetazoa; CBG18986.1; CBG18986.1; WBGene00038277.
DR GeneID; 8579293; -.
DR KEGG; cbr:CBG_18986; -.
DR CTD; 8579293; -.
DR WormBase; CBG18986; CBP04522; WBGene00038277; Cbr-snb-1.
DR eggNOG; KOG0860; Eukaryota.
DR HOGENOM; CLU_064620_4_1_1; -.
DR InParanoid; Q60WU2; -.
DR OMA; CQDTFAT; -.
DR OrthoDB; 1589977at2759; -.
DR Proteomes; UP000008549; Chromosome V.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; IEA:EnsemblMetazoa.
DR GO; GO:0060473; C:cortical granule; IEA:EnsemblMetazoa.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048786; C:presynaptic active zone; IEA:EnsemblMetazoa.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0030421; P:defecation; IEA:EnsemblMetazoa.
DR GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR GO; GO:0043134; P:regulation of hindgut contraction; IEA:EnsemblMetazoa.
DR GO; GO:0043051; P:regulation of pharyngeal pumping; IEA:EnsemblMetazoa.
DR GO; GO:0007271; P:synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:EnsemblMetazoa.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR InterPro; IPR001388; Synaptobrevin.
DR InterPro; IPR016444; Synaptobrevin/VAMP.
DR InterPro; IPR042855; V_SNARE_CC.
DR PANTHER; PTHR45701; PTHR45701; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PIRSF; PIRSF005409; Synaptobrevin_euk; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 3: Inferred from homology;
KW Cell membrane; Coiled coil; Cytoplasmic vesicle; Membrane;
KW Reference proteome; Synapse; Synaptosome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..108
FT /note="Synaptobrevin-1"
FT /id="PRO_0000307353"
FT TOPO_DOM 1..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 22..82
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 108 AA; 11968 MW; FD38670ACD89FCDE CRC64;
MDAQGDAGAQ GGSQGPRPSN KRLQQTQAQV DEVVGIMKVN VEKVLERDQK LSQLDDRADA
LQEGASQFEK SAATLKRKYW WKNIKMMIIM CAIVVILIII IVLWAGGK
