SYB1_SCHPO
ID SYB1_SCHPO Reviewed; 121 AA.
AC Q92356;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 25-MAY-2022, entry version 149.
DE RecName: Full=Synaptobrevin homolog 1;
GN Name=syb1; ORFNames=SPAC6G9.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12565827; DOI=10.1016/s0006-291x(03)00017-2;
RA Edamatsu M., Toyoshima Y.Y.;
RT "Fission yeast synaptobrevin is involved in cytokinesis and cell
RT elongation.";
RL Biochem. Biophys. Res. Commun. 301:641-645(2003).
CC -!- FUNCTION: Involved in membrane trafficking during cytokinesis and cell
CC elongation. {ECO:0000269|PubMed:12565827}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12565827}; Single-
CC pass type IV membrane protein {ECO:0000269|PubMed:12565827}.
CC Note=Accumulates in vesicle-like structures at the medial ring in
CC dividing cells and at the cell ends during interphase.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAB03613.1; -; Genomic_DNA.
DR PIR; T39073; T39073.
DR RefSeq; NP_594120.1; NM_001019544.2.
DR AlphaFoldDB; Q92356; -.
DR SMR; Q92356; -.
DR BioGRID; 278225; 6.
DR STRING; 4896.SPAC6G9.11.1; -.
DR iPTMnet; Q92356; -.
DR MaxQB; Q92356; -.
DR PaxDb; Q92356; -.
DR PRIDE; Q92356; -.
DR EnsemblFungi; SPAC6G9.11.1; SPAC6G9.11.1:pep; SPAC6G9.11.
DR GeneID; 2541731; -.
DR KEGG; spo:SPAC6G9.11; -.
DR PomBase; SPAC6G9.11; syb1.
DR VEuPathDB; FungiDB:SPAC6G9.11; -.
DR eggNOG; KOG0860; Eukaryota.
DR HOGENOM; CLU_064620_2_1_1; -.
DR InParanoid; Q92356; -.
DR OMA; KQTSHKV; -.
DR PhylomeDB; Q92356; -.
DR Reactome; R-SPO-199992; trans-Golgi Network Vesicle Budding.
DR Reactome; R-SPO-264642; Acetylcholine Neurotransmitter Release Cycle.
DR Reactome; R-SPO-6798695; Neutrophil degranulation.
DR Reactome; R-SPO-6811440; Retrograde transport at the Trans-Golgi-Network.
DR Reactome; R-SPO-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-SPO-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-SPO-8980692; RHOA GTPase cycle.
DR Reactome; R-SPO-9013026; RHOB GTPase cycle.
DR Reactome; R-SPO-9013106; RHOC GTPase cycle.
DR Reactome; R-SPO-9013405; RHOD GTPase cycle.
DR Reactome; R-SPO-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR PRO; PR:Q92356; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0051285; C:cell cortex of cell tip; IDA:PomBase.
DR GO; GO:0032153; C:cell division site; IDA:PomBase.
DR GO; GO:0051286; C:cell tip; IDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005768; C:endosome; IDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031097; C:medial cortex; IDA:PomBase.
DR GO; GO:0090619; C:meiotic spindle pole; IDA:PomBase.
DR GO; GO:0005886; C:plasma membrane; IDA:PomBase.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; ISM:PomBase.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0032120; P:ascospore-type prospore membrane formation; IGI:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; NAS:PomBase.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR InterPro; IPR001388; Synaptobrevin.
DR InterPro; IPR016444; Synaptobrevin/VAMP.
DR InterPro; IPR042855; V_SNARE_CC.
DR PANTHER; PTHR45701; PTHR45701; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PIRSF; PIRSF005409; Synaptobrevin_euk; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..121
FT /note="Synaptobrevin homolog 1"
FT /id="PRO_0000206746"
FT TOPO_DOM 1..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..121
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT DOMAIN 31..91
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ SEQUENCE 121 AA; 13469 MW; D10029CA0341D4DA CRC64;
MSEPYDPYIP AEPSAAVRSG NAAASSTPNM KTAAIQQQID DTVGIMRENI SKVSERGERL
DSLQDKTDNL AVSAQGFRRG ANRVRKKMWW KDMRMRLCII IGIIILLVVI IVPIATKFHG
K
