ID   SYBA_DICDI              Reviewed;          95 AA.
AC   Q6TMJ9; Q54VV6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Synaptobrevin-A;
GN   Name=sybA; ORFNames=DDB_G0280061;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RX   PubMed=15075287; DOI=10.1128/ec.3.2.564-566.2004;
RA   Escalante R., Iranfar N., Sastre L., Loomis W.F.;
RT   "Identification of genes dependent on the MADS box transcription factor
RT   SrfA in Dictyostelium discoideum development.";
RL   Eukaryot. Cell 3:564-566(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in the targeting and/or fusion of transport vesicles
CC       to their target membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC       {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
CC   -!- INDUCTION: Regulated by the srfA transcription factor.
CC       {ECO:0000269|PubMed:15075287}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY392436; AAQ98877.1; -; Genomic_DNA.
DR   EMBL; AAFI02000035; EAL67257.1; -; Genomic_DNA.
DR   RefSeq; XP_641249.1; XM_636157.1.
DR   AlphaFoldDB; Q6TMJ9; -.
DR   SMR; Q6TMJ9; -.
DR   STRING; 44689.DDB0214903; -.
DR   PaxDb; Q6TMJ9; -.
DR   EnsemblProtists; EAL67257; EAL67257; DDB_G0280061.
DR   GeneID; 8622381; -.
DR   KEGG; ddi:DDB_G0280061; -.
DR   dictyBase; DDB_G0280061; sybA.
DR   eggNOG; KOG0860; Eukaryota.
DR   HOGENOM; CLU_064620_5_0_1; -.
DR   InParanoid; Q6TMJ9; -.
DR   OMA; KQTSHKV; -.
DR   Reactome; R-DDI-199992; trans-Golgi Network Vesicle Budding.
DR   Reactome; R-DDI-210500; Glutamate Neurotransmitter Release Cycle.
DR   Reactome; R-DDI-449836; Other interleukin signaling.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DDI-8856828; Clathrin-mediated endocytosis.
DR   Reactome; R-DDI-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR   PRO; PR:Q6TMJ9; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR   InterPro; IPR001388; Synaptobrevin.
DR   InterPro; IPR016444; Synaptobrevin/VAMP.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   PANTHER; PTHR45701; PTHR45701; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PIRSF; PIRSF005409; Synaptobrevin_euk; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasmic vesicle; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..95
FT                   /note="Synaptobrevin-A"
FT                   /id="PRO_0000327936"
FT   TOPO_DOM        1..70
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        92..95
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          7..67
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ   SEQUENCE   95 AA;  10876 MW;  49950B35250E0B01 CRC64;
     MSEPVNKVKQ TQQQVDDVTN TMHIAVGKML DNQQKVSELT DKSENMKQGA QQFKKKTNEI
     KRLMWCRNIK LTLIIIAVVV LLLVVIIVPI VLKFT