SYBL_SCHMA
ID SYBL_SCHMA Reviewed; 131 AA.
AC Q27236; Q26550; Q27353;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Synaptobrevin-like protein;
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
RC STRAIN=Puerto Rican;
RX PubMed=7665603; DOI=10.1074/jbc.270.37.21813;
RA Davis R.E., Hardwick C., Tavernier P., Hodgson S., Singh H.;
RT "RNA trans-splicing in flatworms. Analysis of trans-spliced mRNAs and genes
RT in the human parasite, Schistosoma mansoni.";
RL J. Biol. Chem. 270:21813-21819(1995).
CC -!- FUNCTION: Unknown, but synaptobrevins are presumed to be involved in
CC targeting and fusion of synaptic vesicles with the presynaptic membrane
CC as well as in neurotransmitter release.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein
CC {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=Neuronal
CC synaptic vesicles. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=Q27236-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=Q27236-2; Sequence=VSP_006329;
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR EMBL; U30183; AAC46892.1; -; mRNA.
DR EMBL; U30182; AAC46891.1; -; mRNA.
DR EMBL; U30181; AAC46890.1; -; mRNA.
DR EMBL; U30180; AAC46889.1; -; mRNA.
DR EMBL; U30291; AAC46901.1; -; Genomic_DNA.
DR AlphaFoldDB; Q27236; -.
DR SMR; Q27236; -.
DR STRING; 6183.Smp_102160.1; -.
DR eggNOG; KOG0860; Eukaryota.
DR HOGENOM; CLU_1333420_0_0_1; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR001388; Synaptobrevin.
DR InterPro; IPR016444; Synaptobrevin/VAMP.
DR InterPro; IPR042855; V_SNARE_CC.
DR InterPro; IPR028717; VAMP2.
DR PANTHER; PTHR45701; PTHR45701; 1.
DR PANTHER; PTHR45701:SF5; PTHR45701:SF5; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Cytoplasmic vesicle; Membrane;
KW Reference proteome; Synapse; Synaptosome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..131
FT /note="Synaptobrevin-like protein"
FT /id="PRO_0000206763"
FT TOPO_DOM 1..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 82..102
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..131
FT /note="Vesicular"
FT /evidence="ECO:0000305"
FT DOMAIN 18..78
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT REGION 112..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 82..131
FT /note="MLAVLGVLVVILIIVLIVWVVSEQKNKVEQSEHSSHHLVMDNSSHLLSEQ
FT -> YGSFLNKKIKLNKVNIHLIIL (in isoform Short)"
FT /evidence="ECO:0000303|PubMed:7665603"
FT /id="VSP_006329"
SQ SEQUENCE 131 AA; 14842 MW; C104ED22D870BDD2 CRC64;
MLHITTMTDK APIKTNKRLQ QTQAQVNEVV DIMRVNVDKV LERDKNLSEL DGRADALQAG
ASQFEASAGK LKRKFWWKNC KMLAVLGVLV VILIIVLIVW VVSEQKNKVE QSEHSSHHLV
MDNSSHLLSE Q
