SYBU_HUMAN
ID SYBU_HUMAN Reviewed; 663 AA.
AC Q9NX95; A8K354; B3KQX3; B3KU61; Q5R1T1; Q5R1T2; Q5R1T3; Q5Y2M6; Q8ND49;
AC Q8TCR6; Q96D80; Q9P256;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Syntabulin;
DE AltName: Full=Golgi-localized syntaphilin-related protein;
DE AltName: Full=Syntaxin-1-binding protein;
GN Name=SYBU; Synonyms=GOLSYN, KIAA1472;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH KIF5B
RP AND STX1A, AND SUBCELLULAR LOCATION.
RC TISSUE=Brain;
RX PubMed=15459722; DOI=10.1038/ncb1169;
RA Su Q., Cai Q., Gerwin C., Smith C.L., Sheng Z.-H.;
RT "Syntabulin is a microtubule-associated protein implicated in syntaxin
RT transport in neurons.";
RL Nat. Cell Biol. 6:941-953(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5), SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=15656992; DOI=10.1016/j.gene.2004.10.024;
RA Funakoshi E., Nakagawa K.-Y., Hamano A., Hori T., Shimizu A., Asakawa S.,
RA Shimizu N., Ito F.;
RT "Molecular cloning and characterization of gene for Golgi-localized
RT syntaphilin-related protein on human chromosome 8q23.";
RL Gene 344:259-271(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
RC TISSUE=Fetal brain, and Hepatoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 191-663.
RC TISSUE=Amygdala, and Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-663.
RC TISSUE=Brain;
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-396, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Part of a kinesin motor-adapter complex that is critical for
CC the anterograde axonal transport of active zone components and
CC contributes to activity-dependent presynaptic assembly during neuronal
CC development. {ECO:0000250, ECO:0000269|PubMed:15459722}.
CC -!- SUBUNIT: Interacts with STX1A and KIF5B. {ECO:0000269|PubMed:15459722}.
CC -!- INTERACTION:
CC Q9NX95; P54253: ATXN1; NbExp=3; IntAct=EBI-948293, EBI-930964;
CC Q9NX95-5; O15145: ARPC3; NbExp=3; IntAct=EBI-12816095, EBI-351829;
CC Q9NX95-5; P54253: ATXN1; NbExp=6; IntAct=EBI-12816095, EBI-930964;
CC Q9NX95-5; Q7Z460-2: CLASP1; NbExp=3; IntAct=EBI-12816095, EBI-10967515;
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton. Cytoplasmic
CC vesicle. Note=Colocalizes with syntaxin vesicles along microtubules in
CC neuronal processes.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Golgi apparatus membrane; Single-
CC pass membrane protein.
CC -!- SUBCELLULAR LOCATION: [Isoform 4]: Golgi apparatus membrane; Single-
CC pass membrane protein.
CC -!- SUBCELLULAR LOCATION: [Isoform 5]: Golgi apparatus membrane; Single-
CC pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q9NX95-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NX95-2; Sequence=VSP_019719, VSP_019722;
CC Name=3; Synonyms=GOLSYN A;
CC IsoId=Q9NX95-3; Sequence=VSP_019721;
CC Name=4; Synonyms=GOLSYN C;
CC IsoId=Q9NX95-4; Sequence=VSP_019720;
CC Name=5; Synonyms=GOLSYN B;
CC IsoId=Q9NX95-5; Sequence=VSP_019718;
CC -!- TISSUE SPECIFICITY: Isoform 3, isoform 4 and isoform 5 are expressed in
CC HeLa cell line (at protein level). Isoform 3 is expressed in fetal and
CC adult brain. Isoform 4 is expressed in numerous fetal tissues (brain,
CC kidney, liver, lung, and thymus) and in adult brain, kidney, liver,
CC lung, pancreas, colon, prostate, small intestine, testis and thymus.
CC Isoform 5 is expressed in fetal brain, brain and small intestine.
CC {ECO:0000269|PubMed:15656992}.
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DR EMBL; AY705385; AAU93914.1; -; mRNA.
DR EMBL; AB195676; BAD72976.1; -; mRNA.
DR EMBL; AB195677; BAD72977.1; -; mRNA.
DR EMBL; AB195678; BAD72978.1; -; mRNA.
DR EMBL; AB195679; BAD72979.1; -; mRNA.
DR EMBL; AK000373; BAA91121.1; -; mRNA.
DR EMBL; AK090559; BAG52185.1; -; mRNA.
DR EMBL; AK096558; BAG53323.1; -; mRNA.
DR EMBL; AK290469; BAF83158.1; -; mRNA.
DR EMBL; AL713645; CAD28457.2; -; mRNA.
DR EMBL; AL834406; CAD39068.1; -; mRNA.
DR EMBL; CH471060; EAW91937.1; -; Genomic_DNA.
DR EMBL; BC012082; AAH12082.2; -; mRNA.
DR EMBL; AB040905; BAA95996.1; -; mRNA.
DR CCDS; CCDS43763.1; -. [Q9NX95-3]
DR CCDS; CCDS43764.1; -. [Q9NX95-4]
DR CCDS; CCDS47912.1; -. [Q9NX95-1]
DR CCDS; CCDS55271.1; -. [Q9NX95-5]
DR RefSeq; NP_001093213.1; NM_001099743.1. [Q9NX95-3]
DR RefSeq; NP_001093214.1; NM_001099744.1. [Q9NX95-1]
DR RefSeq; NP_001093215.1; NM_001099745.1. [Q9NX95-1]
DR RefSeq; NP_001093216.1; NM_001099746.1. [Q9NX95-5]
DR RefSeq; NP_001093217.1; NM_001099747.1. [Q9NX95-3]
DR RefSeq; NP_001093218.1; NM_001099748.1. [Q9NX95-1]
DR RefSeq; NP_001093219.1; NM_001099749.1. [Q9NX95-5]
DR RefSeq; NP_001093220.1; NM_001099750.1. [Q9NX95-1]
DR RefSeq; NP_001093221.1; NM_001099751.1. [Q9NX95-3]
DR RefSeq; NP_001093222.1; NM_001099752.1. [Q9NX95-1]
DR RefSeq; NP_001093223.1; NM_001099753.1. [Q9NX95-3]
DR RefSeq; NP_001093224.1; NM_001099754.1. [Q9NX95-1]
DR RefSeq; NP_001093225.1; NM_001099755.1. [Q9NX95-5]
DR RefSeq; NP_001093226.1; NM_001099756.1. [Q9NX95-4]
DR RefSeq; NP_001317525.1; NM_001330596.1.
DR RefSeq; NP_060256.3; NM_017786.5. [Q9NX95-3]
DR RefSeq; XP_016869103.1; XM_017013614.1. [Q9NX95-5]
DR RefSeq; XP_016869104.1; XM_017013615.1. [Q9NX95-5]
DR AlphaFoldDB; Q9NX95; -.
DR SMR; Q9NX95; -.
DR BioGRID; 120776; 28.
DR IntAct; Q9NX95; 21.
DR MINT; Q9NX95; -.
DR STRING; 9606.ENSP00000407118; -.
DR iPTMnet; Q9NX95; -.
DR PhosphoSitePlus; Q9NX95; -.
DR BioMuta; SYBU; -.
DR DMDM; 110283010; -.
DR EPD; Q9NX95; -.
DR jPOST; Q9NX95; -.
DR MassIVE; Q9NX95; -.
DR MaxQB; Q9NX95; -.
DR PaxDb; Q9NX95; -.
DR PeptideAtlas; Q9NX95; -.
DR PRIDE; Q9NX95; -.
DR ProteomicsDB; 83059; -. [Q9NX95-1]
DR ProteomicsDB; 83060; -. [Q9NX95-2]
DR ProteomicsDB; 83061; -. [Q9NX95-3]
DR ProteomicsDB; 83062; -. [Q9NX95-4]
DR ProteomicsDB; 83063; -. [Q9NX95-5]
DR Antibodypedia; 42935; 23 antibodies from 13 providers.
DR DNASU; 55638; -.
DR Ensembl; ENST00000276646.14; ENSP00000276646.9; ENSG00000147642.17. [Q9NX95-1]
DR Ensembl; ENST00000399066.7; ENSP00000382019.3; ENSG00000147642.17. [Q9NX95-4]
DR Ensembl; ENST00000408889.7; ENSP00000386196.3; ENSG00000147642.17. [Q9NX95-5]
DR Ensembl; ENST00000408908.6; ENSP00000386154.2; ENSG00000147642.17. [Q9NX95-1]
DR Ensembl; ENST00000422135.5; ENSP00000407118.1; ENSG00000147642.17. [Q9NX95-1]
DR Ensembl; ENST00000433638.1; ENSP00000403544.1; ENSG00000147642.17. [Q9NX95-1]
DR Ensembl; ENST00000440310.5; ENSP00000404369.1; ENSG00000147642.17. [Q9NX95-1]
DR Ensembl; ENST00000446070.6; ENSP00000414748.2; ENSG00000147642.17. [Q9NX95-3]
DR Ensembl; ENST00000528331.5; ENSP00000436041.1; ENSG00000147642.17. [Q9NX95-5]
DR Ensembl; ENST00000528647.5; ENSP00000432501.1; ENSG00000147642.17. [Q9NX95-3]
DR Ensembl; ENST00000532779.5; ENSP00000436266.1; ENSG00000147642.17. [Q9NX95-2]
DR Ensembl; ENST00000533065.5; ENSP00000432962.1; ENSG00000147642.17. [Q9NX95-5]
DR Ensembl; ENST00000533171.5; ENSP00000434679.1; ENSG00000147642.17. [Q9NX95-1]
DR Ensembl; ENST00000533895.5; ENSP00000433446.1; ENSG00000147642.17. [Q9NX95-3]
DR GeneID; 55638; -.
DR KEGG; hsa:55638; -.
DR MANE-Select; ENST00000276646.14; ENSP00000276646.9; NM_001099754.2; NP_001093224.1.
DR UCSC; uc003yni.5; human. [Q9NX95-1]
DR CTD; 55638; -.
DR DisGeNET; 55638; -.
DR GeneCards; SYBU; -.
DR HGNC; HGNC:26011; SYBU.
DR HPA; ENSG00000147642; Tissue enhanced (pancreas).
DR MIM; 611568; gene.
DR neXtProt; NX_Q9NX95; -.
DR OpenTargets; ENSG00000147642; -.
DR PharmGKB; PA165586000; -.
DR VEuPathDB; HostDB:ENSG00000147642; -.
DR eggNOG; ENOG502QQZ1; Eukaryota.
DR GeneTree; ENSGT00520000055634; -.
DR HOGENOM; CLU_019458_0_0_1; -.
DR InParanoid; Q9NX95; -.
DR OMA; IVPTVMW; -.
DR OrthoDB; 391092at2759; -.
DR PhylomeDB; Q9NX95; -.
DR TreeFam; TF332407; -.
DR PathwayCommons; Q9NX95; -.
DR SignaLink; Q9NX95; -.
DR SIGNOR; Q9NX95; -.
DR BioGRID-ORCS; 55638; 21 hits in 1081 CRISPR screens.
DR ChiTaRS; SYBU; human.
DR GeneWiki; GOLSYN; -.
DR GenomeRNAi; 55638; -.
DR Pharos; Q9NX95; Tbio.
DR PRO; PR:Q9NX95; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9NX95; protein.
DR Bgee; ENSG00000147642; Expressed in cerebellar vermis and 177 other tissues.
DR ExpressionAtlas; Q9NX95; baseline and differential.
DR Genevisible; Q9NX95; HS.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0019894; F:kinesin binding; IEA:InterPro.
DR GO; GO:0017075; F:syntaxin-1 binding; IEA:InterPro.
DR GO; GO:0019896; P:axonal transport of mitochondrion; IBA:GO_Central.
DR GO; GO:0060074; P:synapse maturation; IBA:GO_Central.
DR InterPro; IPR026198; Syntabulin.
DR InterPro; IPR028197; Syntaphilin/Syntabulin.
DR PANTHER; PTHR16208:SF4; PTHR16208:SF4; 1.
DR Pfam; PF15290; Syntaphilin; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoplasmic vesicle;
KW Cytoskeleton; Golgi apparatus; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..663
FT /note="Syntabulin"
FT /id="PRO_0000050798"
FT TRANSMEM 606..626
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2..417
FT /note="Sufficient for interaction with KIF5B"
FT /evidence="ECO:0000269|PubMed:15459722"
FT REGION 216..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..417
FT /note="Sufficient for interaction with STX1A"
FT /evidence="ECO:0000269|PubMed:15459722"
FT COILED 271..353
FT /evidence="ECO:0000255"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 50
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 107
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS8"
FT MOD_RES 396
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 555
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS8"
FT VAR_SEQ 1..119
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:15656992"
FT /id="VSP_019718"
FT VAR_SEQ 1..68
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019719"
FT VAR_SEQ 1..8
FT /note="MGPLRESK -> MSNFE (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15656992"
FT /id="VSP_019720"
FT VAR_SEQ 8
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15656992"
FT /id="VSP_019721"
FT VAR_SEQ 69..76
FT /note="VSSNSFCS -> MGPFWARK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019722"
FT CONFLICT 8
FT /note="K -> KMSNFE (in Ref. 4; CAD28457)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="R -> G (in Ref. 3; BAG53323)"
FT /evidence="ECO:0000305"
FT CONFLICT 440
FT /note="D -> G (in Ref. 3; BAA91121)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 663 AA; 72388 MW; 41521DBD4AAE733B CRC64;
MGPLRESKKE HRVQHHDKEI SRSRIPRLIL RPHMPQQQHK VSPASESPFS EEESREFNPS
SSGRSARTVS SNSFCSDDTG CPSSQSVSPV KTPSDAGNSP IGFCPGSDEG FTRKKCTIGM
VGEGSIQSSR YKKESKSGLV KPGSEADFSS SSSTGSISAP EVHMSTAGSK RSSSSRNRGP
HGRSNGASSH KPGSSPSSPR EKDLLSMLCR NQLSPVNIHP SYAPSSPSSS NSGSYKGSDC
SPIMRRSGRY MSCGENHGVR PPNPEQYLTP LQQKEVTVRH LKTKLKESER RLHERESEIV
ELKSQLARMR EDWIEEECHR VEAQLALKEA RKEIKQLKQV IETMRSSLAD KDKGIQKYFV
DINIQNKKLE SLLQSMEMAH SGSLRDELCL DFPCDSPEKS LTLNPPLDTM ADGLSLEEQV
TGEGADRELL VGDSIANSTD LFDEIVTATT TESGDLELVH STPGANVLEL LPIVMGQEEG
SVVVERAVQT DVVPYSPAIS ELIQSVLQKL QDPCPSSLAS PDESEPDSME SFPESLSALV
VDLTPRNPNS AILLSPVETP YANVDAEVHA NRLMRELDFA ACVEERLDGV IPLARGGVVR
QYWSSSFLVD LLAVAAPVVP TVLWAFSTQR GGTDPVYNIG ALLRGCCVVA LHSLRRTAFR
IKT
