ID   SYB_DORPE               Reviewed;         125 AA.
AC   P47194;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Synaptobrevin;
OS   Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Decapodiformes; Teuthida; Myopsina; Loliginidae; Doryteuthis.
OX   NCBI_TaxID=1051067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8011337; DOI=10.1016/0896-6273(94)90443-x;
RA   Hunt J.M., Bommert K., Charlton M.P., Kistner A., Habermann E.,
RA   Augustine G.J., Betz H.;
RT   "A post-docking role for synaptobrevin in synaptic vesicle fusion.";
RL   Neuron 12:1269-1279(1994).
CC   -!- FUNCTION: Intrinsic membrane protein of small synaptic vesicles.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane; Single-pass type IV membrane protein. Synapse,
CC       synaptosome. Note=Neuronal synaptic vesicles.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR   EMBL; X74748; CAA52766.1; -; mRNA.
DR   PIR; S40153; S40153.
DR   PDB; 1L4A; X-ray; 2.95 A; A=25-104.
DR   PDBsum; 1L4A; -.
DR   AlphaFoldDB; P47194; -.
DR   SMR; P47194; -.
DR   IntAct; P47194; 1.
DR   MINT; P47194; -.
DR   PRIDE; P47194; -.
DR   EvolutionaryTrace; P47194; -.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR001388; Synaptobrevin.
DR   InterPro; IPR016444; Synaptobrevin/VAMP.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   InterPro; IPR028717; VAMP2.
DR   PANTHER; PTHR45701; PTHR45701; 1.
DR   PANTHER; PTHR45701:SF5; PTHR45701:SF5; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Coiled coil; Cytoplasmic vesicle; Membrane; Synapse;
KW   Synaptosome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..125
FT                   /note="Synaptobrevin"
FT                   /id="PRO_0000206742"
FT   TOPO_DOM        1..103
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..123
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..125
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          40..100
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..34
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           40..77
FT                   /evidence="ECO:0007829|PDB:1L4A"
FT   TURN            78..82
FT                   /evidence="ECO:0007829|PDB:1L4A"
FT   TURN            84..87
FT                   /evidence="ECO:0007829|PDB:1L4A"
FT   HELIX           88..96
FT                   /evidence="ECO:0007829|PDB:1L4A"
SQ   SEQUENCE   125 AA;  13316 MW;  6FE9E5604ECABD86 CRC64;
     MSGPQNPQAG PGGPPSGPPQ PGGPPGPPQG PPQPVQQSKR LQQTQAQVEE VVDIMRVNVD
     KVLERDSKIS ELDDRADALQ AGASQFEASA GKLKRKFWWK NCKMMIILGG IVAVIVTVII
     VWAAT