SYC1L_HUMAN
ID SYC1L_HUMAN Reviewed; 242 AA.
AC A8MT33; A6NF23;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 3.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Synaptonemal complex central element protein 1-like;
DE AltName: Full=Meiosis-related protein;
GN Name=SYCE1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-218.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in meiosis. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SYCE family. {ECO:0000305}.
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DR EMBL; AC009139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DV080252; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS45533.1; -.
DR RefSeq; NP_001123451.1; NM_001129979.1.
DR AlphaFoldDB; A8MT33; -.
DR SMR; A8MT33; -.
DR BioGRID; 935003; 37.
DR STRING; 9606.ENSP00000367911; -.
DR iPTMnet; A8MT33; -.
DR PhosphoSitePlus; A8MT33; -.
DR BioMuta; SYCE1L; -.
DR jPOST; A8MT33; -.
DR MassIVE; A8MT33; -.
DR PaxDb; A8MT33; -.
DR PeptideAtlas; A8MT33; -.
DR PRIDE; A8MT33; -.
DR ProteomicsDB; 1993; -.
DR Antibodypedia; 67122; 56 antibodies from 11 providers.
DR DNASU; 100130958; -.
DR Ensembl; ENST00000378644.5; ENSP00000367911.4; ENSG00000205078.6.
DR GeneID; 100130958; -.
DR KEGG; hsa:100130958; -.
DR MANE-Select; ENST00000378644.5; ENSP00000367911.4; NM_001129979.3; NP_001123451.1.
DR UCSC; uc010vnh.2; human.
DR CTD; 100130958; -.
DR DisGeNET; 100130958; -.
DR GeneCards; SYCE1L; -.
DR HGNC; HGNC:37236; SYCE1L.
DR HPA; ENSG00000205078; Tissue enhanced (testis).
DR neXtProt; NX_A8MT33; -.
DR OpenTargets; ENSG00000205078; -.
DR VEuPathDB; HostDB:ENSG00000205078; -.
DR eggNOG; ENOG502QZY9; Eukaryota.
DR GeneTree; ENSGT00390000017352; -.
DR HOGENOM; CLU_068366_1_0_1; -.
DR InParanoid; A8MT33; -.
DR OMA; RILQMHC; -.
DR OrthoDB; 1275708at2759; -.
DR PhylomeDB; A8MT33; -.
DR PathwayCommons; A8MT33; -.
DR BioGRID-ORCS; 100130958; 9 hits in 1074 CRISPR screens.
DR ChiTaRS; SYCE1L; human.
DR GenomeRNAi; 100130958; -.
DR Pharos; A8MT33; Tdark.
DR PRO; PR:A8MT33; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; A8MT33; protein.
DR Bgee; ENSG00000205078; Expressed in right testis and 91 other tissues.
DR ExpressionAtlas; A8MT33; baseline and differential.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
DR GO; GO:0000795; C:synaptonemal complex; IBA:GO_Central.
DR GO; GO:0007130; P:synaptonemal complex assembly; IEA:InterPro.
DR InterPro; IPR026676; SYCE1.
DR PANTHER; PTHR21731; PTHR21731; 1.
DR Pfam; PF15233; SYCE1; 2.
PE 2: Evidence at transcript level;
KW Coiled coil; Meiosis; Reference proteome.
FT CHAIN 1..242
FT /note="Synaptonemal complex central element protein 1-like"
FT /id="PRO_0000341221"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 44..181
FT /evidence="ECO:0000255"
SQ SEQUENCE 242 AA; 27397 MW; EA60AA7D1259D03E CRC64;
MAGKLKPLNV EAPEATEEAE GQAKSLKTED LLAMVIKLQK EGSLEPQIED LISRINDLQQ
AKKKSSEELR ETHSLWEALH RELDSLNGEK VHLEEVLGKK QEALRILQMH CQEKESEAQR
LDVRGQLEDL MGQHKDLWEF HMLEQRLARE IRALERSKEQ LLSERRLVRA KLREVERRLH
SPPEVEGAMA VNDGLKAELE IFGEQVRSAP EVGAGEGEAG PELPRARDEE DPEPPVAAPD
AL
