SYC1L_MOUSE
ID SYC1L_MOUSE Reviewed; 247 AA.
AC Q5D525; B2RUQ1; Q497L4; Q5D524; Q9D5A5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Synaptonemal complex central element protein 1-like;
DE AltName: Full=Meiosis-related protein;
GN Name=Syce1l; Synonyms=Mmrp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, DEVELOPMENTAL
RP STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Testis;
RX PubMed=16328886; DOI=10.1007/s11033-005-3005-1;
RA Gu S., Hu J., Song P., Gong W., Guo M.;
RT "Identification of a new transcript specifically expressed in mouse
RT spermatocytes: mmrp2.";
RL Mol. Biol. Rep. 32:247-255(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in meiosis. Isoform 1 may be involved in
CC meiosis during spermatogenesis while isoform 2 is probably related to a
CC later stage of meiosis, in the development stage of secondary
CC spermatocytes and spermatids. {ECO:0000269|PubMed:16328886}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=mmrp2;
CC IsoId=Q5D525-1; Sequence=Displayed;
CC Name=2; Synonyms=mmrp1;
CC IsoId=Q5D525-2; Sequence=VSP_034228;
CC Name=3;
CC IsoId=Q5D525-3; Sequence=VSP_034227;
CC -!- TISSUE SPECIFICITY: Isoform 1 is abundantly expressed in testis and
CC weakly in ovary, it is not found in other tissues. Isoform 2 is
CC expressed in testis and poorly in brain, heart, lung and other examined
CC tissues. {ECO:0000269|PubMed:16328886}.
CC -!- DEVELOPMENTAL STAGE: Not detected in embryo. Isoform 1 is detected in
CC testis at day 8 after birth while isoform 2 at day 17.
CC {ECO:0000269|PubMed:16328886}.
CC -!- SIMILARITY: Belongs to the SYCE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI00479.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY899936; AAX18326.1; -; mRNA.
DR EMBL; AY899935; AAX18325.1; -; mRNA.
DR EMBL; AK015606; BAB29903.1; -; mRNA.
DR EMBL; BC100478; AAI00479.1; ALT_INIT; mRNA.
DR EMBL; BC141326; AAI41327.1; -; mRNA.
DR EMBL; BC141347; AAI41348.1; -; mRNA.
DR CCDS; CCDS40483.1; -. [Q5D525-1]
DR CCDS; CCDS40484.1; -. [Q5D525-2]
DR CCDS; CCDS85617.1; -. [Q5D525-3]
DR RefSeq; NP_001041610.1; NM_001048145.1. [Q5D525-1]
DR RefSeq; NP_001273423.1; NM_001286494.1. [Q5D525-3]
DR RefSeq; NP_083415.1; NM_029139.1. [Q5D525-2]
DR AlphaFoldDB; Q5D525; -.
DR SMR; Q5D525; -.
DR IntAct; Q5D525; 1.
DR STRING; 10090.ENSMUSP00000092796; -.
DR PhosphoSitePlus; Q5D525; -.
DR PaxDb; Q5D525; -.
DR PRIDE; Q5D525; -.
DR ProteomicsDB; 258678; -. [Q5D525-1]
DR ProteomicsDB; 258679; -. [Q5D525-2]
DR ProteomicsDB; 258680; -. [Q5D525-3]
DR Antibodypedia; 67122; 56 antibodies from 11 providers.
DR Ensembl; ENSMUST00000034219; ENSMUSP00000034219; ENSMUSG00000033409. [Q5D525-2]
DR Ensembl; ENSMUST00000095173; ENSMUSP00000092796; ENSMUSG00000033409. [Q5D525-1]
DR Ensembl; ENSMUST00000212269; ENSMUSP00000148356; ENSMUSG00000033409. [Q5D525-3]
DR GeneID; 668110; -.
DR KEGG; mmu:668110; -.
DR UCSC; uc009nnp.1; mouse. [Q5D525-2]
DR UCSC; uc009nnq.1; mouse. [Q5D525-1]
DR UCSC; uc012glc.1; mouse. [Q5D525-3]
DR CTD; 100130958; -.
DR MGI; MGI:1922247; Syce1l.
DR VEuPathDB; HostDB:ENSMUSG00000033409; -.
DR eggNOG; ENOG502QZY9; Eukaryota.
DR GeneTree; ENSGT00390000017352; -.
DR HOGENOM; CLU_1146884_0_0_1; -.
DR InParanoid; Q5D525; -.
DR OMA; RILQMHC; -.
DR OrthoDB; 1275708at2759; -.
DR PhylomeDB; Q5D525; -.
DR BioGRID-ORCS; 668110; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Syce1l; mouse.
DR PRO; PR:Q5D525; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q5D525; protein.
DR Bgee; ENSMUSG00000033409; Expressed in seminiferous tubule of testis and 28 other tissues.
DR Genevisible; Q5D525; MM.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; ISO:MGI.
DR GO; GO:0000795; C:synaptonemal complex; IBA:GO_Central.
DR GO; GO:0007130; P:synaptonemal complex assembly; IEA:InterPro.
DR InterPro; IPR026676; SYCE1.
DR PANTHER; PTHR21731; PTHR21731; 1.
DR Pfam; PF15233; SYCE1; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Meiosis; Reference proteome.
FT CHAIN 1..247
FT /note="Synaptonemal complex central element protein 1-like"
FT /id="PRO_0000341222"
FT REGION 189..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 71..196
FT /evidence="ECO:0000255"
FT COMPBIAS 222..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 23..43
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034227"
FT VAR_SEQ 125..247
FT /note="HLDAQQLEERLADLARQHKDLWEFHVLQQRLAQEISTMEHRKDQLLAERTLL
FT RARLEKVEQRLQEARETWDSPGNCGLKTELEELEGQSQRSPEAQNDKGEASQEEQHHLE
FT TSEELPRTGTLC -> QKCTVQFSGFRPKKLGLLLSLQLGCSTTGGEAGGSGKATQGPL
FT GVPCPAAATGPGDQHDGAQERSASCREDSAASQAGEGGAAAAGGQRDLGQPRELWAEDR
FT AGGIGGAVPAQPRSSE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072,
FT ECO:0000303|PubMed:16328886"
FT /id="VSP_034228"
FT CONFLICT 4
FT /note="E -> G (in Ref. 1; AAX18325/AAX18326)"
FT /evidence="ECO:0000305"
FT CONFLICT 10
FT /note="A -> E (in Ref. 1; AAX18325/AAX18326)"
FT /evidence="ECO:0000305"
FT CONFLICT 105
FT /note="K -> E (in Ref. 1; AAX18325/AAX18326)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 247 AA; 28461 MW; E9B413F5DA4861DA CRC64;
MAAELEPLMA EWLGAEKAED TRGQAASLNT MEDLLETVKK LQKEGSLEPQ IEDLIHRINE
LQQGPAKKRS SEELGEAQAL QEAMHRELDS LNEERVHLEE VLRKKQEAVS ILKKHPQERD
SDTPHLDAQQ LEERLADLAR QHKDLWEFHV LQQRLAQEIS TMEHRKDQLL AERTLLRARL
EKVEQRLQEA RETWDSPGNC GLKTELEELE GQSQRSPEAQ NDKGEASQEE QHHLETSEEL
PRTGTLC
