SYC2L_MOUSE
ID SYC2L_MOUSE Reviewed; 842 AA.
AC A0A0M3U1B0; D3YWV8; F6RWL8; F6ZC70;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 09-DEC-2015, sequence version 1.
DT 03-AUG-2022, entry version 36.
DE RecName: Full=Synaptonemal complex protein 2-like;
DE Short=SCP-2-like;
GN Name=Sycp2l {ECO:0000312|MGI:MGI:2685114};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC STRAIN=C57BL/6J;
RX PubMed=26362258; DOI=10.1093/hmg/ddv359;
RA Zhou J., Stein P., Leu N.A., Chmatal L., Xue J., Ma J., Huang X.,
RA Lampson M.A., Schultz R.M., Wang P.J.;
RT "Accelerated reproductive aging in females lacking a novel centromere
RT protein SYCP2L.";
RL Hum. Mol. Genet. 24:6505-6514(2015).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Oocyte-specific protein that localizes to centromeres at the
CC dictyate stage and regulates the survival of primordial oocytes.
CC {ECO:0000269|PubMed:26362258}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26362258}.
CC Chromosome, centromere {ECO:0000269|PubMed:26362258}. Note=Localized to
CC the synaptonemal complex lateral elements in late diplotene oocytes,
CC while it is absent on the synaptonemal complex of leptotene, zygotene,
CC pachytene and early diplotene oocytes (PubMed:26362258). Localizes to
CC centromeres in dictyate oocytes (PubMed:26362258). Detected in nuclear
CC granules and sizable aggregates (By similarity).
CC {ECO:0000250|UniProtKB:Q5T4T6, ECO:0000269|PubMed:26362258}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in oocytes.
CC {ECO:0000269|PubMed:26362258}.
CC -!- DISRUPTION PHENOTYPE: Reduced fertility in females: acceleration of the
CC age-associated decline of fertility in female mice, due to progressive
CC loss of oocytes. Males are normal and fertile.
CC {ECO:0000269|PubMed:26362258}.
CC -!- SIMILARITY: Belongs to the SYCP2 family. {ECO:0000305}.
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DR EMBL; KP872825; ALE66119.1; -; mRNA.
DR EMBL; AC158538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS88444.1; -.
DR RefSeq; NP_001311454.1; NM_001324525.1.
DR AlphaFoldDB; A0A0M3U1B0; -.
DR SMR; A0A0M3U1B0; -.
DR STRING; 10090.ENSMUSP00000115127; -.
DR iPTMnet; A0A0M3U1B0; -.
DR PhosphoSitePlus; A0A0M3U1B0; -.
DR Antibodypedia; 48559; 20 antibodies from 9 providers.
DR DNASU; 637277; -.
DR Ensembl; ENSMUST00000124093; ENSMUSP00000115127; ENSMUSG00000038651.
DR GeneID; 637277; -.
DR KEGG; mmu:637277; -.
DR CTD; 221711; -.
DR MGI; MGI:2685114; Sycp2l.
DR VEuPathDB; HostDB:ENSMUSG00000038651; -.
DR eggNOG; ENOG502QSX7; Eukaryota.
DR GeneTree; ENSGT00530000063859; -.
DR OMA; EGACCLM; -.
DR OrthoDB; 285929at2759; -.
DR TreeFam; TF332368; -.
DR BioGRID-ORCS; 637277; 0 hits in 2 CRISPR screens.
DR ChiTaRS; Sycp2l; mouse.
DR PRO; PR:A0A0M3U1B0; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; A0A0M3U1B0; protein.
DR Bgee; ENSMUSG00000038651; Expressed in animal zygote and 11 other tissues.
DR ExpressionAtlas; A0A0M3U1B0; baseline and differential.
DR GO; GO:0000779; C:condensed chromosome, centromeric region; IDA:MGI.
DR GO; GO:0001674; C:female germ cell nucleus; IDA:MGI.
DR GO; GO:0000800; C:lateral element; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0140013; P:meiotic nuclear division; IBA:GO_Central.
DR GO; GO:0060548; P:negative regulation of cell death; IMP:MGI.
DR InterPro; IPR024835; SYCP2-like.
DR InterPro; IPR041322; SYCP2_ARLD.
DR InterPro; IPR040560; SYCP2_SLD.
DR PANTHER; PTHR15607; PTHR15607; 1.
DR Pfam; PF18581; SYCP2_ARLD; 1.
DR Pfam; PF18584; SYCP2_SLD; 1.
PE 2: Evidence at transcript level;
KW Centromere; Chromosome; Nucleus; Reference proteome.
FT CHAIN 1..842
FT /note="Synaptonemal complex protein 2-like"
FT /id="PRO_0000441742"
FT REGION 451..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 96055 MW; F7AFEB1A2FCF6691 CRC64;
MSTLQSLIID GFHGNGFHMI EEYLQQKESH VPQKYNHLLL HHLDRLIKEE LDKNEFQNCS
LLLKCIQRFF RDDPDHEEPL LIQQGLIPKM VSWFEIITGL LITKVLASEA LLTNALEDFL
DTALIISRHS RKATVQMLDS FILRLGFLVA EDSVKPSIQQ ETLATLNCIL NAAPQEERRK
LSSAEGACCL MKELARTILT VGDYSQQVAL SEALCRMSVG RQRNDLAMQW FENTALAEAF
KKIKNREFET DCRQFLNFLN NRLGNQRRVY SFPCLAAFAD GQEMRKPADE KLEEFWIDFN
LGSQSVTFYI DNAESALWEP VKLLKEAMVK FIIIENDRIK MFIVYLKQPI VISKREAKKI
EIHFDRQLGI LQASIQALGE DKQAPSFQTS VLVKLFSGLE KEDGEIPGRC EREAEDAEES
TLLPELVDAE ADRCLITRCF NVQTVPGVSK GSLEITNTEE RSLENSKQDE PEQVTSEYDY
PLDMQEPSIQ NQASDLNNIK EDSAFARDRE QDRRMPFNDR NHDLLESNED SSLSTNERSW
TQNHKRKSLR TYSQRKKQRV SSLRILPLSP IRSGHAPEKD EAELVPLWKG ISRRNDSTLL
KISETKLRGS SVLLTSGAST QKIGLEKPER RGSEPSSSTK KTRVTDGLHW REPRSPHPSS
GPSSLEYLEV EENIPEIVNR ESFMGNSSFK HKLENLGHRE IPDGSVAALK QSRLEDAPGS
PVVTDTSTPS QEDMPGSVNG SAFKTAFENF TRDLKRKFEL ELKQREIPFS LEKAKEAPAC
LIRLWNQIHT CRLDTLERFH SSVLRELSGL EKNLQTLKCL EKDALASLLF VLSLGRERTF
SR
