SYC2L_XENLA
ID SYC2L_XENLA Reviewed; 977 AA.
AC Q90WN7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Synaptonemal complex protein 2-like;
DE Short=SCP-2-like;
DE AltName: Full=145 kDa nucleolar protein {ECO:0000303|PubMed:11739789};
GN Name=sycp2l; Synonyms=no145 {ECO:0000303|PubMed:11739789};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 36-42; 44-52; 54-60;
RP 112-117; 348-360; 375-380; 440-450; 525-537; 622-626; 763-782; 894-910;
RP 915-926 AND 940-953, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Ovary;
RX PubMed=11739789; DOI=10.1091/mbc.12.12.3904;
RA Kneissel S., Franke W.W., Gall J.G., Heid H., Reidenbach S., Schnoelzer M.,
RA Spring H., Zentgraf H., Schmidt-Zachmann M.S.;
RT "A novel karyoskeletal protein: characterization of protein NO145, the
RT major component of nucleolar cortical skeleton in Xenopus oocytes.";
RL Mol. Biol. Cell 12:3904-3918(2001).
RN [2]
RP UBIQUITINATION, PHOSPHORYLATION, PROTEASOMAL DEGRADATION, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=17374641; DOI=10.1242/jcs.000166;
RA Voltmer-Irsch S., Kneissel S., Adenot P.G., Schmidt-Zachmann M.S.;
RT "Regulatory mechanisms governing the oocyte-specific synthesis of the
RT karyoskeletal protein NO145.";
RL J. Cell Sci. 120:1412-1422(2007).
CC -!- FUNCTION: Oocyte-specific protein that localizes to centromeres at the
CC dictyate stage and regulates the survival of primordial oocytes.
CC {ECO:0000250|UniProtKB:A0A0M3U1B0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0A0M3U1B0}.
CC Chromosome, centromere {ECO:0000250|UniProtKB:A0A0M3U1B0}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:11739789}. Note=Localized to the
CC synaptonemal complex lateral elements in late diplotene oocytes, while
CC it is absent on the synaptonemal complex of leptotene, zygotene,
CC pachytene and early diplotene oocytes. Localizes to centromeres in
CC dictyate oocytes (By similarity). Detected in nuclear granules and
CC sizable aggregates (By similarity). Localized in a cage-like cortical
CC structure around the entire nucleolus, consisting of a meshwork of
CC patches and filaments. {ECO:0000250|UniProtKB:A0A0M3U1B0,
CC ECO:0000250|UniProtKB:Q5T4T6, ECO:0000269|PubMed:11739789}.
CC -!- TISSUE SPECIFICITY: Expressed in immature oocytes (at protein level).
CC Expressed in the ovary. {ECO:0000269|PubMed:11739789}.
CC -!- DEVELOPMENTAL STAGE: Expressed in oocytes throughout oogenesis.
CC Undetectable in eggs and during early embryonic stages up to the
CC tailbud stage (at protein level). Expressed during early embryonic
CC stages beyond stage 8 (mid-blastula transition; MBT).
CC {ECO:0000269|PubMed:11739789, ECO:0000269|PubMed:17374641}.
CC -!- PTM: Ubiquitinated and gradually degraded by the proteasome during
CC oocyte maturation. {ECO:0000269|PubMed:17374641}.
CC -!- PTM: Phosphorylated in maturing oocytes, before its degradation.
CC {ECO:0000269|PubMed:17374641}.
CC -!- SIMILARITY: Belongs to the SYCP2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ249963; CAC80718.2; -; mRNA.
DR RefSeq; NP_001082126.1; NM_001088657.1.
DR AlphaFoldDB; Q90WN7; -.
DR SMR; Q90WN7; -.
DR GeneID; 398239; -.
DR KEGG; xla:398239; -.
DR CTD; 398239; -.
DR Xenbase; XB-GENE-919983; sycp2l.S.
DR OrthoDB; 285929at2759; -.
DR Proteomes; UP000186698; Chromosome 6S.
DR Bgee; 398239; Expressed in gastrula and 7 other tissues.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR InterPro; IPR024835; SYCP2-like.
DR InterPro; IPR041322; SYCP2_ARLD.
DR InterPro; IPR040560; SYCP2_SLD.
DR PANTHER; PTHR15607; PTHR15607; 1.
DR Pfam; PF18581; SYCP2_ARLD; 1.
DR Pfam; PF18584; SYCP2_SLD; 1.
PE 1: Evidence at protein level;
KW Centromere; Chromosome; Direct protein sequencing; Nucleus; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..977
FT /note="Synaptonemal complex protein 2-like"
FT /id="PRO_0000333810"
FT REGION 447..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 977 AA; 111354 MW; 82CB1A58656E056F CRC64;
MSEDGAQTAE KMDTHTQYYL ESLIIDALKG KGFQKIIELF DGKVIFSSQF HNKLLLSQLD
KLINKELDRN EFKHVSVLMK CIQHFCKNDC QESSTLIHQG LVSKMVLWFE RTVDFLRISK
EATLLTLVED FYDSALVICK CNCEDGKRQL LDSFLIRLGH LVTEKWVACH LRLEALRTIN
CILDSISRED KKKLHCSEDL CELTKDLART IQEAGDYDIQ VAISEALCRM MGKKFRDSFV
HQWFEDNFLA DAFKEIKDKE FETDCRKFLN CLNSRHQSNK GVYTFPCITV FTDLDELKKP
QDENMENFWI DFNAGSQCVS FYIHNTEGSL WDSVRLLKES VNNYTLKEND GQQMLGIYLK
DPQVINTNDV TKVKIYFEPK HDIKSAIKRV FEDINEIHSN PVELDSTEGL IDIGNSLASH
TVITTATTFK QWKRNQANKM DSASDILGSQ TSEHSSTTKT SSANRSVQKS LSNADSHEIV
IESVPLEAVI TIADEQPNTA QFQDDMDDAI FQGAASDVPA KDSSQEIIII TEASADKEFA
AKKTQGIFQF QGYSDTLASD QVSDAKKKIL LPKQSTERAT PASRYRASMN SPLQRTSSAY
RSHLFCESNE VTSNTESERS WIQDFKNKSA VKSADYSCEK TRNKSKRKVL PLASESGDDE
KQVDTTETVA RFTSRKEMHR PEDINPKSPH SAELKLPGIS ALLTPGDSRS QSKSDYRYQS
AIDDQDIMDP VEEASSPEMS IDHNKEPKNG HDEVYASGPL NRSVDGNNIY HAADTLQHAT
GKRKHKTCER EEIPFKPRKL FSSTEKNVNR SAADSEDSED VFYSESHDQD LAEASVLSAF
DSFTKELKRK FLTRYKRIEN RANHVLKSSH QQVSTVLNEI HQCRLQKINH FNKIVVHELS
SLEAEVQALK QFEKETLDFW EDQYVKMNTF CSSQTQRIKT MDSALLETIS NLKNVIQKTT
KEEVSNTEEH IQNKLLK
