ID   SYCE1_BOVIN             Reviewed;         323 AA.
AC   Q32LK9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Synaptonemal complex central element protein 1;
GN   Name=SYCE1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Major component of the transverse central element of
CC       synaptonemal complexes (SCS), formed between homologous chromosomes
CC       during meiotic prophase. Requires SYCP1 in order to be incorporated
CC       into the central element. May have a role in the synaptonemal complex
CC       assembly, stabilization and recombination.
CC       {ECO:0000250|UniProtKB:Q9D495}.
CC   -!- SUBUNIT: Homodimer. Found in a complex with SYCP1 and SYCE2. Interacts
CC       with SYCP1, SYCE2 and SYCE3. Interacts with SIX6OS1.
CC       {ECO:0000250|UniProtKB:Q9D495}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D495}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9D495}. Note=Associates with
CC       chromatin. In prophase I stage of meiosis, localizes in the transverse
CC       central elements of the central region between lateral elements of the
CC       synaptonemal complexes. Found only where the chromosome cores are
CC       synapsed. Colocalizes with SYCE2 in the central elements.
CC       {ECO:0000250|UniProtKB:Q9D495}.
CC   -!- SIMILARITY: Belongs to the SYCE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI09529.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC109528; AAI09529.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001033238.2; NM_001038149.2.
DR   AlphaFoldDB; Q32LK9; -.
DR   SMR; Q32LK9; -.
DR   STRING; 9913.ENSBTAP00000046422; -.
DR   PaxDb; Q32LK9; -.
DR   GeneID; 529478; -.
DR   KEGG; bta:529478; -.
DR   CTD; 93426; -.
DR   eggNOG; ENOG502S24D; Eukaryota.
DR   HOGENOM; CLU_068366_0_0_1; -.
DR   InParanoid; Q32LK9; -.
DR   OrthoDB; 1275708at2759; -.
DR   TreeFam; TF337303; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0000795; C:synaptonemal complex; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007130; P:synaptonemal complex assembly; IEA:InterPro.
DR   InterPro; IPR026676; SYCE1.
DR   PANTHER; PTHR21731; PTHR21731; 1.
DR   Pfam; PF15233; SYCE1; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Chromosome; Coiled coil; Meiosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..323
FT                   /note="Synaptonemal complex central element protein 1"
FT                   /id="PRO_0000261425"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          25..290
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   323 AA;  36776 MW;  3FD3D770E4A44082 CRC64;
     MAGRPGSSNA EAAGAVGPTD EARGQAESSQ KIEDLMEMVK KLQKVGSLEP RVEVLINRIN
     EVQQAKKKAS EELGDARTVW ETLQKELDSL SGEKVRLKEI LSKKQETLRV LRLHCQDKEN
     EAQRKQTMLQ ECKERISALN SQIEQEKNKQ RQLRLDFEEQ LEDLMGQYKD LWEFHKPERL
     ALEISTLDSG KEQLLKEEKL VEAKLEDVKH RLCSQFGAKG HTINEGLFLR SPEAAAVVHL
     FEEENRKAQE LLEAAAQRQE QLQQKCQQLQ QKRQRLKEEL EKLGVQVLAQ AQSKQEEEAG
     LGEAANPKPL GVSEEKDQEP STK