ID   SYCE1_MACFA             Reviewed;         313 AA.
AC   Q4R7J8;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Synaptonemal complex central element protein 1;
GN   Name=SYCE1; ORFNames=QtsA-15065;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Major component of the transverse central element of
CC       synaptonemal complexes (SCS), formed between homologous chromosomes
CC       during meiotic prophase. Requires SYCP1 in order to be incorporated
CC       into the central element. May have a role in the synaptonemal complex
CC       assembly, stabilization and recombination.
CC       {ECO:0000250|UniProtKB:Q9D495}.
CC   -!- SUBUNIT: Homodimer. Found in a complex with SYCP1 and SYCE2. Interacts
CC       with SYCP1, SYCE2 and SYCE3. Interacts with SIX6OS1.
CC       {ECO:0000250|UniProtKB:Q9D495}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D495}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9D495}. Note=Associates with
CC       chromatin. In prophase I stage of meiosis, localizes in the transverse
CC       central elements of the central region between lateral elements of the
CC       synaptonemal complexes. Found only where the chromosome cores are
CC       synapsed. Colocalizes with SYCE2 in the central elements.
CC       {ECO:0000250|UniProtKB:Q9D495}.
CC   -!- SIMILARITY: Belongs to the SYCE family. {ECO:0000305}.
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DR   EMBL; AB168820; BAE00924.1; -; mRNA.
DR   RefSeq; NP_001270762.1; NM_001283833.1.
DR   AlphaFoldDB; Q4R7J8; -.
DR   SMR; Q4R7J8; -.
DR   STRING; 9541.XP_005566859.1; -.
DR   GeneID; 101925477; -.
DR   CTD; 93426; -.
DR   eggNOG; ENOG502S24D; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0000795; C:synaptonemal complex; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007130; P:synaptonemal complex assembly; IEA:InterPro.
DR   InterPro; IPR026676; SYCE1.
DR   PANTHER; PTHR21731; PTHR21731; 1.
DR   Pfam; PF15233; SYCE1; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Chromosome; Coiled coil; Meiosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..313
FT                   /note="Synaptonemal complex central element protein 1"
FT                   /id="PRO_0000261427"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          261..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          29..281
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        293..307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   313 AA;  35536 MW;  BC01CB6AA410BCAC CRC64;
     MAGRSLASKA EPTAGAMDGA EKAEGQDTSS QKIEVEVLIN RINEAQQAKK KANEDLGEAR
     TICEALQKEL DLLHGEKVHL KEILSKKQET LRILRLHCQE KESEAQRKHT VLQECKERIS
     ALSLQIEEEK NKQRQLRLAF EEQLEELMGQ HKDLWDFHRP ERLAREICAL DSNKEQLLKE
     EKLVKATLED VKHQLCSLCG AEGPSTLDEG LFLRSQEAAA TVQLFQEEHR KAEELLAAAA
     QSHQQLQQKC QQLQQKRQRL KEELEKRGMQ VHAQAQSTQE EEAGPGDVAS PKPLKAPEEK
     DLELHTEQDL MSS