SYCE1_MOUSE
ID SYCE1_MOUSE Reviewed; 329 AA.
AC Q9D495;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Synaptonemal complex central element protein 1;
GN Name=Syce1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP FUNCTION, IDENTIFICATION IN A COMPLEX WITH SYCP1 AND SYCE2, INTERACTION
RP WITH SYCP1 AND SYCE2, HOMODIMERIZATION, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND TISSUE SPECIFICITY.
RX PubMed=15944401; DOI=10.1242/jcs.02402;
RA Costa Y., Speed R., Oellinger R., Alsheimer M., Semple C.A., Gautier P.,
RA Maratou K., Novak I., Hoeoeg C., Benavente R., Cooke H.J.;
RT "Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are
RT at the center of meiosis.";
RL J. Cell Sci. 118:2755-2762(2005).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH SYCP1.
RX PubMed=16968740; DOI=10.1242/jcs.03182;
RA Hamer G., Gell K., Kouznetsova A., Novak I., Benavente R., Hoeoeg C.;
RT "Characterization of a novel meiosis-specific protein within the central
RT element of the synaptonemal complex.";
RL J. Cell Sci. 119:4025-4032(2006).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP INTERACTION WITH SYCE3.
RX PubMed=21637789; DOI=10.1371/journal.pgen.1002088;
RA Schramm S., Fraune J., Naumann R., Hernandez-Hernandez A., Hoog C.,
RA Cooke H.J., Alsheimer M., Benavente R.;
RT "A novel mouse synaptonemal complex protein is essential for loading of
RT central element proteins, recombination, and fertility.";
RL PLoS Genet. 7:E1002088-E1002088(2011).
RN [6]
RP INTERACTION WITH SIX6OS1.
RX PubMed=27796301; DOI=10.1038/ncomms13298;
RA Gomez-H L., Felipe-Medina N., Sanchez-Martin M., Davies O.R., Ramos I.,
RA Garcia-Tunon I., de Rooij D.G., Dereli I., Toth A., Barbero J.L.,
RA Benavente R., Llano E., Pendas A.M.;
RT "C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is
RT essential for mouse fertility.";
RL Nat. Commun. 7:13298-13298(2016).
CC -!- FUNCTION: Major component of the transverse central element of
CC synaptonemal complexes (SCS), formed between homologous chromosomes
CC during meiotic prophase (PubMed:15944401). Requires SYCP1 in order to
CC be incorporated into the central element (PubMed:15944401,
CC PubMed:16968740). May have a role in the synaptonemal complex assembly,
CC stabilization and recombination (PubMed:15944401).
CC {ECO:0000269|PubMed:15944401, ECO:0000269|PubMed:16968740}.
CC -!- SUBUNIT: Homodimer (PubMed:15944401). Found in a complex with SYCP1 and
CC SYCE2 (PubMed:15944401). Interacts with SYCP1, SYCE2 and SYCE3
CC (PubMed:15944401, PubMed:21637789, PubMed:16968740). Interacts with
CC SIX6OS1 (PubMed:27796301). {ECO:0000269|PubMed:15944401,
CC ECO:0000269|PubMed:16968740, ECO:0000269|PubMed:21637789,
CC ECO:0000269|PubMed:27796301}.
CC -!- INTERACTION:
CC Q9D495; B5KM66: Syce3; NbExp=2; IntAct=EBI-6128757, EBI-6128737;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15944401}. Chromosome
CC {ECO:0000269|PubMed:15944401, ECO:0000269|PubMed:16968740}.
CC Note=Associates with chromatin. In prophase I stage of meiosis,
CC localizes in the transverse central elements of the central region
CC between lateral elements of the synaptonemal complexes. Found only
CC where the chromosome cores are synapsed. Colocalizes with SYCE2 in the
CC central elements. {ECO:0000269|PubMed:15944401}.
CC -!- TISSUE SPECIFICITY: Meiotic cells (at protein level). Expressed in the
CC ovary and testis. {ECO:0000269|PubMed:15944401}.
CC -!- DEVELOPMENTAL STAGE: Expressed in testis at 14 dpc and in oocytes at 18
CC dpc. {ECO:0000269|PubMed:15944401}.
CC -!- SIMILARITY: Belongs to the SYCE family. {ECO:0000305}.
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DR EMBL; AK016694; BAB30383.1; -; mRNA.
DR CCDS; CCDS52436.1; -.
DR RefSeq; NP_001137237.1; NM_001143765.1.
DR AlphaFoldDB; Q9D495; -.
DR SMR; Q9D495; -.
DR BioGRID; 216471; 3.
DR CORUM; Q9D495; -.
DR IntAct; Q9D495; 1.
DR STRING; 10090.ENSMUSP00000026553; -.
DR iPTMnet; Q9D495; -.
DR PhosphoSitePlus; Q9D495; -.
DR PaxDb; Q9D495; -.
DR PeptideAtlas; Q9D495; -.
DR PRIDE; Q9D495; -.
DR ProteomicsDB; 258683; -.
DR Antibodypedia; 46492; 82 antibodies from 19 providers.
DR Ensembl; ENSMUST00000026553; ENSMUSP00000026553; ENSMUSG00000025480.
DR GeneID; 74075; -.
DR KEGG; mmu:74075; -.
DR UCSC; uc009kid.2; mouse.
DR CTD; 93426; -.
DR MGI; MGI:1921325; Syce1.
DR VEuPathDB; HostDB:ENSMUSG00000025480; -.
DR eggNOG; ENOG502S24D; Eukaryota.
DR GeneTree; ENSGT00390000017352; -.
DR HOGENOM; CLU_068366_0_0_1; -.
DR InParanoid; Q9D495; -.
DR OMA; EFHKPEQ; -.
DR OrthoDB; 1275708at2759; -.
DR PhylomeDB; Q9D495; -.
DR TreeFam; TF337303; -.
DR BioGRID-ORCS; 74075; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Syce1; mouse.
DR PRO; PR:Q9D495; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D495; protein.
DR Bgee; ENSMUSG00000025480; Expressed in seminiferous tubule of testis and 32 other tissues.
DR ExpressionAtlas; Q9D495; baseline and differential.
DR Genevisible; Q9D495; MM.
DR GO; GO:0000801; C:central element; IDA:HGNC-UCL.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0000795; C:synaptonemal complex; ISS:MGI.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007130; P:synaptonemal complex assembly; IC:MGI.
DR InterPro; IPR026676; SYCE1.
DR PANTHER; PTHR21731; PTHR21731; 1.
DR Pfam; PF15233; SYCE1; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Chromosome; Coiled coil; Meiosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..329
FT /note="Synaptonemal complex central element protein 1"
FT /id="PRO_0000261428"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 54..167
FT /evidence="ECO:0000255"
FT COILED 194..294
FT /evidence="ECO:0000255"
FT COMPBIAS 310..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 38205 MW; E843B245EDE1C029 CRC64;
MATRPQPLGM EPEGSADLLH GPEGARGQYG STQKIEDLMD MVKKLQKVGS LEPRIEVLIN
RINEVQQAKK KASEELGEAQ TVWDNLQKEL DLLREEKVRL KDILNRKEET LRIMQLHCQE
KESEAQRKHS MLQECKERIS FLNSQIDKEK AKLRKLRLDF EEHLETLMSQ HKDTLEFHKP
EHLTKEMCVL DSSKEQLLKE EKLMKVKLED VRQRLCALGG PEGSSSLIEG LFLRSHEAAA
AMQMFKDENK KAEEFLEAAA QQHEQLQQRC HQLQQKRQRL KEELEKHGVQ ILAHSTQNEE
DSSWRMASPK PVEVHEETAQ DQERPSSRT
