ID   SYCE1_RAT               Reviewed;         329 AA.
AC   Q5XHZ2;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Synaptonemal complex central element protein 1;
GN   Name=Syce1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Major component of the transverse central element of
CC       synaptonemal complexes (SCS), formed between homologous chromosomes
CC       during meiotic prophase. Requires SYCP1 in order to be incorporated
CC       into the central element. May have a role in the synaptonemal complex
CC       assembly, stabilization and recombination.
CC       {ECO:0000250|UniProtKB:Q9D495}.
CC   -!- SUBUNIT: Homodimer. Found in a complex with SYCP1 and SYCE2. Interacts
CC       with SYCP1, SYCE2 and SYCE3. Interacts with SIX6OS1.
CC       {ECO:0000250|UniProtKB:Q9D495}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D495}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9D495}. Note=Associates with
CC       chromatin. In prophase I stage of meiosis, localizes in the transverse
CC       central elements of the central region between lateral elements of the
CC       synaptonemal complexes. Found only where the chromosome cores are
CC       synapsed. Colocalizes with SYCE2 in the central elements.
CC       {ECO:0000250|UniProtKB:Q9D495}.
CC   -!- SIMILARITY: Belongs to the SYCE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH83907.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC083907; AAH83907.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001020229.2; NM_001025058.2.
DR   AlphaFoldDB; Q5XHZ2; -.
DR   SMR; Q5XHZ2; -.
DR   STRING; 10116.ENSRNOP00000035554; -.
DR   PaxDb; Q5XHZ2; -.
DR   Ensembl; ENSRNOT00000033074; ENSRNOP00000035554; ENSRNOG00000024073.
DR   GeneID; 502372; -.
DR   KEGG; rno:502372; -.
DR   UCSC; RGD:1559853; rat.
DR   CTD; 93426; -.
DR   RGD; 1559853; Syce1.
DR   eggNOG; ENOG502S24D; Eukaryota.
DR   GeneTree; ENSGT00390000017352; -.
DR   HOGENOM; CLU_068366_0_0_1; -.
DR   InParanoid; Q5XHZ2; -.
DR   OMA; EFHKPEQ; -.
DR   OrthoDB; 1275708at2759; -.
DR   PhylomeDB; Q5XHZ2; -.
DR   TreeFam; TF337303; -.
DR   PRO; PR:Q5XHZ2; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000024073; Expressed in testis and 11 other tissues.
DR   GO; GO:0000801; C:central element; ISO:RGD.
DR   GO; GO:0005694; C:chromosome; ISO:RGD.
DR   GO; GO:0000795; C:synaptonemal complex; IDA:MGI.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007130; P:synaptonemal complex assembly; IEA:InterPro.
DR   InterPro; IPR026676; SYCE1.
DR   PANTHER; PTHR21731; PTHR21731; 1.
DR   Pfam; PF15233; SYCE1; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Chromosome; Coiled coil; Meiosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..329
FT                   /note="Synaptonemal complex central element protein 1"
FT                   /id="PRO_0000261429"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          28..168
FT                   /evidence="ECO:0000255"
FT   COILED          194..294
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        305..329
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  38157 MW;  AB7D9D2BC107027F CRC64;
     MATRPQPLSV EPEGSADLLH GPEGARGRRG STQKIEDLME MVEKLQKVGS LEPRIEVLIN
     RINEVQQAKK KASEELGEAQ TVWDTLQKEV DSLHEEKVRL KDILNRKEET LRIMQLHCQE
     KESEAERKHS MLQECKDRIS FLNNQIDNEK AKLRRLRLDF EEHLETLMSQ HKDTMEFHKP
     EHLTEEMSVL DSSKEQLLKE EKLIKAKLED VQHRLCALCG PEGSSTFSDG LFLRSHEAAA
     AMQMFKDENK KAEELLEAAA QQHQQLQQRC RQLQQKRQRL KEELEKHGVQ ILAQIQSTQK
     EEDSSWRTAS PKPLEAHKET VQERPSSRT