SYCE2_HUMAN
ID SYCE2_HUMAN Reviewed; 218 AA.
AC Q6PIF2; B4DYD3;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Synaptonemal complex central element protein 2;
DE AltName: Full=Central element synaptonemal complex protein 1 {ECO:0000250|UniProtKB:Q505B8};
GN Name=SYCE2; Synonyms=CESC1 {ECO:0000250|UniProtKB:Q505B8};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-161.
RC TISSUE=Lymphoma;
RA Ebert L., Heil O., Hennig S., Korn B., Neubert P., Partsch E., Peters M.,
RA Radelof U., Schneider D.;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-217.
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Major component of the transverse central element of
CC synaptonemal complexes (SCS), formed between homologous chromosomes
CC during meiotic prophase. Requires SYCP1 in order to be incorporated
CC into the central element. May have a role in the synaptonemal complex
CC assembly, stabilization and recombination (By similarity).
CC {ECO:0000250|UniProtKB:Q505B8}.
CC -!- SUBUNIT: Homodimer. Found in a complex with SYCP1 and SYCE1. Interacts
CC with SYCP1, SYCE1 and SYCE3 (By similarity). Interacts with TEX12 (By
CC similarity). {ECO:0000250|UniProtKB:Q505B8}.
CC -!- INTERACTION:
CC Q6PIF2; A0A1B0GWI1: CCDC196; NbExp=8; IntAct=EBI-11958386, EBI-10181422;
CC Q6PIF2; Q16543: CDC37; NbExp=3; IntAct=EBI-11958386, EBI-295634;
CC Q6PIF2; Q05329: GAD2; NbExp=3; IntAct=EBI-11958386, EBI-9304251;
CC Q6PIF2; Q86YM7: HOMER1; NbExp=3; IntAct=EBI-11958386, EBI-746815;
CC Q6PIF2; Q8IY31-3: IFT20; NbExp=3; IntAct=EBI-11958386, EBI-9091197;
CC Q6PIF2; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-11958386, EBI-14069005;
CC Q6PIF2; Q9P086: MED11; NbExp=3; IntAct=EBI-11958386, EBI-394704;
CC Q6PIF2; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-11958386, EBI-394607;
CC Q6PIF2; Q96NT1: NAP1L5; NbExp=5; IntAct=EBI-11958386, EBI-713627;
CC Q6PIF2; Q9BXU0: TEX12; NbExp=5; IntAct=EBI-11958386, EBI-12090309;
CC Q6PIF2; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-11958386, EBI-11525489;
CC Q6PIF2; Q8N7C3: TRIML2; NbExp=5; IntAct=EBI-11958386, EBI-11059915;
CC Q6PIF2; Q99598: TSNAX; NbExp=3; IntAct=EBI-11958386, EBI-742638;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q505B8}.
CC Chromosome {ECO:0000250|UniProtKB:Q505B8}. Note=Associates with
CC chromatin. In prophase I stage of meiosis, localizes in the transverse
CC central elements of the central region between lateral elements of the
CC synaptonemal complexes. Found only where the chromosome cores are
CC synapsed. Colocalizes with SYCE1 in the central elements (By
CC similarity). {ECO:0000250|UniProtKB:Q505B8}.
CC -!- SIMILARITY: Belongs to the SYCE family. {ECO:0000305}.
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DR EMBL; AK302373; BAG63695.1; -; mRNA.
DR EMBL; AD000092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR746484; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC035819; AAH35819.1; -; mRNA.
DR CCDS; CCDS42509.1; -.
DR RefSeq; NP_001099048.1; NM_001105578.1.
DR PDB; 6R17; X-ray; 2.42 A; A/B=57-165.
DR PDB; 6YQF; X-ray; 3.33 A; A/B=57-165.
DR PDBsum; 6R17; -.
DR PDBsum; 6YQF; -.
DR AlphaFoldDB; Q6PIF2; -.
DR SMR; Q6PIF2; -.
DR BioGRID; 129139; 25.
DR IntAct; Q6PIF2; 13.
DR STRING; 9606.ENSP00000293695; -.
DR iPTMnet; Q6PIF2; -.
DR PhosphoSitePlus; Q6PIF2; -.
DR BioMuta; SYCE2; -.
DR DMDM; 118573898; -.
DR jPOST; Q6PIF2; -.
DR MassIVE; Q6PIF2; -.
DR PaxDb; Q6PIF2; -.
DR PeptideAtlas; Q6PIF2; -.
DR PRIDE; Q6PIF2; -.
DR ProteomicsDB; 67154; -.
DR Antibodypedia; 49860; 76 antibodies from 15 providers.
DR DNASU; 256126; -.
DR Ensembl; ENST00000293695.8; ENSP00000293695.6; ENSG00000161860.8.
DR GeneID; 256126; -.
DR KEGG; hsa:256126; -.
DR MANE-Select; ENST00000293695.8; ENSP00000293695.6; NM_001105578.2; NP_001099048.1.
DR UCSC; uc002mvr.3; human.
DR CTD; 256126; -.
DR DisGeNET; 256126; -.
DR GeneCards; SYCE2; -.
DR HGNC; HGNC:27411; SYCE2.
DR HPA; ENSG00000161860; Tissue enriched (testis).
DR MalaCards; SYCE2; -.
DR MIM; 611487; gene.
DR neXtProt; NX_Q6PIF2; -.
DR OpenTargets; ENSG00000161860; -.
DR PharmGKB; PA142670849; -.
DR VEuPathDB; HostDB:ENSG00000161860; -.
DR eggNOG; ENOG502S7EK; Eukaryota.
DR GeneTree; ENSGT00390000004872; -.
DR HOGENOM; CLU_117939_0_0_1; -.
DR InParanoid; Q6PIF2; -.
DR OMA; RQGVDMP; -.
DR OrthoDB; 1458052at2759; -.
DR PhylomeDB; Q6PIF2; -.
DR TreeFam; TF333776; -.
DR PathwayCommons; Q6PIF2; -.
DR Reactome; R-HSA-1221632; Meiotic synapsis.
DR SignaLink; Q6PIF2; -.
DR SIGNOR; Q6PIF2; -.
DR BioGRID-ORCS; 256126; 15 hits in 1080 CRISPR screens.
DR ChiTaRS; SYCE2; human.
DR GenomeRNAi; 256126; -.
DR Pharos; Q6PIF2; Tbio.
DR PRO; PR:Q6PIF2; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6PIF2; protein.
DR Bgee; ENSG00000161860; Expressed in right testis and 95 other tissues.
DR ExpressionAtlas; Q6PIF2; baseline and differential.
DR Genevisible; Q6PIF2; HS.
DR GO; GO:0000801; C:central element; ISS:HGNC.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007130; P:synaptonemal complex assembly; NAS:BHF-UCL.
DR InterPro; IPR034609; Syce2.
DR PANTHER; PTHR28398; PTHR28398; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Chromosome; Coiled coil; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..218
FT /note="Synaptonemal complex central element protein 2"
FT /id="PRO_0000262562"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 61..87
FT /evidence="ECO:0000255"
FT COMPBIAS 1..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 59..149
FT /evidence="ECO:0007829|PDB:6R17"
SQ SEQUENCE 218 AA; 24690 MW; 8E95680492B0E5C2 CRC64;
MERQGVDVPH VKCKDQEPQP LGESKEHPRW EENCEEEAGG GPASASCQLT VLEGKSGLYF
SSLDSSIDIL QKRAQELIEN INKSRQKDHA LMTNFRNSLK TKVSDLTEKL EERIYQIYND
HNKIIQEKLQ EFTQKMAKIS HLETELKQVC HSVETVYKDL CLQPEQSLRL RWGPDHSRGK
SPPRPGNSQP PDVFVSSVAE TTSQATASEV QTNRDGEC
