SYCE2_MOUSE
ID SYCE2_MOUSE Reviewed; 171 AA.
AC Q505B8; Q3TJR1; Q9DAC4;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Synaptonemal complex central element protein 2;
DE AltName: Full=Central element synaptonemal complex protein 1 {ECO:0000303|PubMed:15944401};
GN Name=Syce2; Synonyms=Cesc1 {ECO:0000303|PubMed:15944401};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Placenta, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, IDENTIFICATION IN A COMPLEX WITH SYCP1 AND SYCE1, INTERACTION
RP WITH SYCP1 AND SYCE1, HOMODIMERIZATION, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND TISSUE SPECIFICITY.
RX PubMed=15944401; DOI=10.1242/jcs.02402;
RA Costa Y., Speed R., Oellinger R., Alsheimer M., Semple C.A., Gautier P.,
RA Maratou K., Novak I., Hoeoeg C., Benavente R., Cooke H.J.;
RT "Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are
RT at the center of meiosis.";
RL J. Cell Sci. 118:2755-2762(2005).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH TEX12.
RX PubMed=16968740; DOI=10.1242/jcs.03182;
RA Hamer G., Gell K., Kouznetsova A., Novak I., Benavente R., Hoeoeg C.;
RT "Characterization of a novel meiosis-specific protein within the central
RT element of the synaptonemal complex.";
RL J. Cell Sci. 119:4025-4032(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP INTERACTION WITH SYCE3.
RX PubMed=21637789; DOI=10.1371/journal.pgen.1002088;
RA Schramm S., Fraune J., Naumann R., Hernandez-Hernandez A., Hoog C.,
RA Cooke H.J., Alsheimer M., Benavente R.;
RT "A novel mouse synaptonemal complex protein is essential for loading of
RT central element proteins, recombination, and fertility.";
RL PLoS Genet. 7:E1002088-E1002088(2011).
CC -!- FUNCTION: Major component of the transverse central element of
CC synaptonemal complexes (SCS), formed between homologous chromosomes
CC during meiotic prophase (PubMed:15944401). Requires SYCP1 in order to
CC be incorporated into the central element (PubMed:15944401,
CC PubMed:16968740). May have a role in the synaptonemal complex assembly,
CC stabilization and recombination (PubMed:15944401).
CC {ECO:0000269|PubMed:15944401, ECO:0000269|PubMed:16968740}.
CC -!- SUBUNIT: Homodimer (PubMed:15944401). Found in a complex with SYCP1 and
CC SYCE1 (PubMed:15944401). Interacts with SYCP1 and SYCE1
CC (PubMed:15944401). Interacts with SYCE3 (PubMed:21637789). Interacts
CC with TEX12 (PubMed:16968740). {ECO:0000269|PubMed:15944401,
CC ECO:0000269|PubMed:16968740, ECO:0000269|PubMed:21637789}.
CC -!- INTERACTION:
CC Q505B8; B5KM66: Syce3; NbExp=2; IntAct=EBI-6131573, EBI-6128737;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15944401}. Chromosome
CC {ECO:0000269|PubMed:15944401, ECO:0000269|PubMed:16968740}.
CC Note=Associates with chromatin. In prophase I stage of meiosis,
CC localizes in the transverse central elements of the central region
CC between lateral elements of the synaptonemal complexes. Found only
CC where the chromosome cores are synapsed. Colocalizes with SYCE1 in the
CC central elements.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q505B8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q505B8-2; Sequence=VSP_021788;
CC -!- TISSUE SPECIFICITY: Meiotic cells (at protein level). Expressed in the
CC ovary and testis. {ECO:0000269|PubMed:15944401}.
CC -!- DEVELOPMENTAL STAGE: Expressed in ovary, embryo, spleen, thymus, brain,
CC kidney, epididymis, heart and liver at 14 dpc and in oocytes at 18 dpc.
CC {ECO:0000269|PubMed:15944401}.
CC -!- SIMILARITY: Belongs to the SYCE family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK005954; BAB24337.1; -; mRNA.
DR EMBL; AK167332; BAE39434.1; -; mRNA.
DR EMBL; BC094628; AAH94628.1; -; mRNA.
DR CCDS; CCDS22481.1; -. [Q505B8-1]
DR RefSeq; NP_001161716.1; NM_001168244.1. [Q505B8-2]
DR RefSeq; NP_082230.2; NM_027954.3. [Q505B8-1]
DR AlphaFoldDB; Q505B8; -.
DR SMR; Q505B8; -.
DR BioGRID; 214975; 6.
DR CORUM; Q505B8; -.
DR IntAct; Q505B8; 5.
DR STRING; 10090.ENSMUSP00000122159; -.
DR iPTMnet; Q505B8; -.
DR PhosphoSitePlus; Q505B8; -.
DR REPRODUCTION-2DPAGE; IPI00321051; -.
DR EPD; Q505B8; -.
DR MaxQB; Q505B8; -.
DR PaxDb; Q505B8; -.
DR PRIDE; Q505B8; -.
DR ProteomicsDB; 258785; -. [Q505B8-1]
DR ProteomicsDB; 258786; -. [Q505B8-2]
DR Antibodypedia; 49860; 76 antibodies from 15 providers.
DR DNASU; 71846; -.
DR Ensembl; ENSMUST00000136026; ENSMUSP00000122159; ENSMUSG00000003824. [Q505B8-1]
DR GeneID; 71846; -.
DR KEGG; mmu:71846; -.
DR UCSC; uc009mnv.2; mouse. [Q505B8-1]
DR CTD; 256126; -.
DR MGI; MGI:1919096; Syce2.
DR VEuPathDB; HostDB:ENSMUSG00000003824; -.
DR eggNOG; ENOG502S7EK; Eukaryota.
DR GeneTree; ENSGT00390000004872; -.
DR HOGENOM; CLU_117939_0_0_1; -.
DR InParanoid; Q505B8; -.
DR OMA; RQGVDMP; -.
DR PhylomeDB; Q505B8; -.
DR TreeFam; TF333776; -.
DR BioGRID-ORCS; 71846; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Syce2; mouse.
DR PRO; PR:Q505B8; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q505B8; protein.
DR Bgee; ENSMUSG00000003824; Expressed in primary oocyte and 234 other tissues.
DR ExpressionAtlas; Q505B8; baseline and differential.
DR Genevisible; Q505B8; MM.
DR GO; GO:0000801; C:central element; IDA:HGNC-UCL.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000795; C:synaptonemal complex; ISS:MGI.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007130; P:synaptonemal complex assembly; IC:MGI.
DR InterPro; IPR034609; Syce2.
DR PANTHER; PTHR28398; PTHR28398; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Chromosome; Coiled coil;
KW Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..171
FT /note="Synaptonemal complex central element protein 2"
FT /id="PRO_0000262563"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 52..83
FT /evidence="ECO:0000255"
FT COILED 118..146
FT /evidence="ECO:0000255"
FT COMPBIAS 19..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..83
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021788"
FT CONFLICT 26
FT /note="E -> K (in Ref. 1; BAB24337)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 171 AA; 19558 MW; B0517F1D9B8BF9F6 CRC64;
MERHGVAAPP VELKDQEPPA IVESGEHRQS ENHEETPGSV APSASCQLPG PFSSLDSSIE
TLKKKAQELI ENINESRQKD HALMTNFRDS LKMKVSDLTE KLEERMYQVY SHHSKIIQER
LQEFTQKMAK INHLEMELKQ VCQTVETVYK DLCVQSEVPT CEEQNYKDGE C
