ID   SYCE3_HUMAN             Reviewed;          88 AA.
AC   A1L190;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Synaptonemal complex central element protein 3;
DE   AltName: Full=Testis highly expressed gene 2 protein;
DE            Short=THEG-2;
GN   Name=SYCE3; Synonyms=C22orf41, THEG2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Liu Y., Gu Z., Wang Z., Cai J., Jiang G., Zheng L., Zeng F., Tong Q.;
RT   "Cloning of THEG-2, a novel gene highly expressed in human testis.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Major component of the transverse central element of
CC       synaptonemal complexes (SCS), formed between homologous chromosomes
CC       during meiotic prophase. Required for chromosome loading of the central
CC       element-specific SCS proteins, and for initiating synapsis between
CC       homologous chromosomes. Chromosome loading appears to require SYCP1.
CC       Required for fertility. {ECO:0000250|UniProtKB:B5KM66}.
CC   -!- SUBUNIT: Homodimer. Interacts with SYCE1. Interacts with SYCE2.
CC       Interacts with proteasome subunit PSMA8; to participate in meiosis
CC       progression during spermatogenesis (By similarity). Interacts with
CC       SPO16 (By similarity). {ECO:0000250|UniProtKB:B5KM66}.
CC   -!- INTERACTION:
CC       A1L190; Q9UL45: BLOC1S6; NbExp=3; IntAct=EBI-10283466, EBI-465781;
CC       A1L190; Q96CS2: HAUS1; NbExp=4; IntAct=EBI-10283466, EBI-2514791;
CC       A1L190; P42858: HTT; NbExp=15; IntAct=EBI-10283466, EBI-466029;
CC       A1L190; O14901: KLF11; NbExp=3; IntAct=EBI-10283466, EBI-948266;
CC       A1L190; Q5XKE5: KRT79; NbExp=3; IntAct=EBI-10283466, EBI-2514135;
CC       A1L190; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-10283466, EBI-2811583;
CC       A1L190; Q16512: PKN1; NbExp=3; IntAct=EBI-10283466, EBI-602382;
CC       A1L190; P60891: PRPS1; NbExp=3; IntAct=EBI-10283466, EBI-749195;
CC       A1L190; Q96ES7: SGF29; NbExp=3; IntAct=EBI-10283466, EBI-743117;
CC       A1L190; O76024: WFS1; NbExp=3; IntAct=EBI-10283466, EBI-720609;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B5KM66}.
CC       Chromosome {ECO:0000250|UniProtKB:B5KM66}. Note=Colocalizes with SYCE1
CC       in the central elements. {ECO:0000250|UniProtKB:B5KM66}.
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DR   EMBL; EU082028; ABU52998.1; -; mRNA.
DR   EMBL; CH471138; EAW73567.1; -; Genomic_DNA.
DR   EMBL; BC127859; AAI27860.1; -; mRNA.
DR   EMBL; BC127860; AAI27861.1; -; mRNA.
DR   CCDS; CCDS46733.1; -.
DR   RefSeq; NP_001116697.1; NM_001123225.2.
DR   AlphaFoldDB; A1L190; -.
DR   SMR; A1L190; -.
DR   BioGRID; 569383; 62.
DR   IntAct; A1L190; 53.
DR   STRING; 9606.ENSP00000385480; -.
DR   iPTMnet; A1L190; -.
DR   PhosphoSitePlus; A1L190; -.
DR   BioMuta; SYCE3; -.
DR   MassIVE; A1L190; -.
DR   MaxQB; A1L190; -.
DR   PaxDb; A1L190; -.
DR   PeptideAtlas; A1L190; -.
DR   PRIDE; A1L190; -.
DR   ProteomicsDB; 137; -.
DR   Antibodypedia; 62384; 12 antibodies from 7 providers.
DR   DNASU; 644186; -.
DR   Ensembl; ENST00000402753.1; ENSP00000385122.1; ENSG00000217442.4.
DR   Ensembl; ENST00000406915.4; ENSP00000385480.3; ENSG00000217442.4.
DR   GeneID; 644186; -.
DR   KEGG; hsa:644186; -.
DR   MANE-Select; ENST00000406915.4; ENSP00000385480.3; NM_001123225.3; NP_001116697.1.
DR   UCSC; uc003bmj.5; human.
DR   CTD; 644186; -.
DR   DisGeNET; 644186; -.
DR   GeneCards; SYCE3; -.
DR   HGNC; HGNC:35245; SYCE3.
DR   HPA; ENSG00000217442; Tissue enriched (testis).
DR   MIM; 615775; gene.
DR   neXtProt; NX_A1L190; -.
DR   OpenTargets; ENSG00000217442; -.
DR   PharmGKB; PA164717081; -.
DR   VEuPathDB; HostDB:ENSG00000217442; -.
DR   eggNOG; ENOG502S4TF; Eukaryota.
DR   GeneTree; ENSGT00390000009978; -.
DR   HOGENOM; CLU_2548975_0_0_1; -.
DR   InParanoid; A1L190; -.
DR   OMA; MVVIRTN; -.
DR   OrthoDB; 1545114at2759; -.
DR   PhylomeDB; A1L190; -.
DR   PathwayCommons; A1L190; -.
DR   Reactome; R-HSA-1221632; Meiotic synapsis.
DR   SignaLink; A1L190; -.
DR   SIGNOR; A1L190; -.
DR   BioGRID-ORCS; 644186; 15 hits in 1067 CRISPR screens.
DR   ChiTaRS; SYCE3; human.
DR   GenomeRNAi; 644186; -.
DR   Pharos; A1L190; Tdark.
DR   PRO; PR:A1L190; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; A1L190; protein.
DR   Bgee; ENSG00000217442; Expressed in left testis and 111 other tissues.
DR   Genevisible; A1L190; HS.
DR   GO; GO:0000801; C:central element; ISS:UniProtKB.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0051094; P:positive regulation of developmental process; IEA:Ensembl.
DR   GO; GO:2000243; P:positive regulation of reproductive process; IEA:Ensembl.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR   InterPro; IPR028145; Synaptonemal_3.
DR   PANTHER; PTHR36686; PTHR36686; 1.
DR   Pfam; PF15191; Synaptonemal_3; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Chromosome; Coiled coil; Meiosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..88
FT                   /note="Synaptonemal complex central element protein 3"
FT                   /id="PRO_0000367274"
FT   COILED          7..75
FT                   /evidence="ECO:0000255"
FT   VARIANT         88
FT                   /note="L -> P (in dbSNP:rs6009989)"
FT                   /id="VAR_060126"
SQ   SEQUENCE   88 AA;  10601 MW;  9A038411E08A2760 CRC64;
     MDDADPEERN YDNMLKMLSD LNKDLEKLLE EMEKISVQAT WMAYDMVVMR TNPTLAESMR
     RLEDAFVNCK EEMEKNWQEL LHETKQRL