ID   SYCN_HUMAN              Reviewed;         134 AA.
AC   Q0VAF6;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Syncollin;
DE   AltName: Full=Insulin synthesis-associated protein 1;
DE   Flags: Precursor;
GN   Name=SYCN; Synonyms=INSSA1, SYL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Functions in exocytosis in pancreatic acinar cells regulating
CC       the fusion of zymogen granules with each other. May have a pore-forming
CC       activity on membranes and regulate exocytosis in other exocrine tissues
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer and homooligomer; most probably hexameric. Interacts
CC       with GP2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Zymogen granule membrane
CC       {ECO:0000250|UniProtKB:O35775}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O35775}; Lumenal side
CC       {ECO:0000250|UniProtKB:O35775}. Zymogen granule lumen
CC       {ECO:0000250|UniProtKB:O35775}. Note=Associated in a cholesterol-
CC       dependent manner with lipid rafts of zymogen granule membranes.
CC       {ECO:0000250|UniProtKB:O35775}.
CC   -!- PTM: Contains intrachain disulfide bonds. {ECO:0000250}.
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DR   EMBL; BC121075; AAI21076.1; -; mRNA.
DR   EMBL; BC121076; AAI21077.1; -; mRNA.
DR   CCDS; CCDS46070.1; -.
DR   RefSeq; NP_001073937.1; NM_001080468.3.
DR   AlphaFoldDB; Q0VAF6; -.
DR   SMR; Q0VAF6; -.
DR   BioGRID; 131205; 8.
DR   IntAct; Q0VAF6; 1.
DR   STRING; 9606.ENSP00000325564; -.
DR   iPTMnet; Q0VAF6; -.
DR   PhosphoSitePlus; Q0VAF6; -.
DR   BioMuta; SYCN; -.
DR   DMDM; 121948659; -.
DR   MassIVE; Q0VAF6; -.
DR   PaxDb; Q0VAF6; -.
DR   PeptideAtlas; Q0VAF6; -.
DR   PRIDE; Q0VAF6; -.
DR   ProteomicsDB; 58794; -.
DR   TopDownProteomics; Q0VAF6; -.
DR   Antibodypedia; 30273; 78 antibodies from 16 providers.
DR   DNASU; 342898; -.
DR   Ensembl; ENST00000318438.7; ENSP00000325564.6; ENSG00000179751.7.
DR   GeneID; 342898; -.
DR   KEGG; hsa:342898; -.
DR   MANE-Select; ENST00000318438.7; ENSP00000325564.6; NM_001080468.4; NP_001073937.1.
DR   UCSC; uc002okr.3; human.
DR   CTD; 342898; -.
DR   DisGeNET; 342898; -.
DR   GeneCards; SYCN; -.
DR   HGNC; HGNC:18442; SYCN.
DR   HPA; ENSG00000179751; Tissue enriched (pancreas).
DR   neXtProt; NX_Q0VAF6; -.
DR   OpenTargets; ENSG00000179751; -.
DR   PharmGKB; PA142670850; -.
DR   VEuPathDB; HostDB:ENSG00000179751; -.
DR   eggNOG; ENOG502S3UP; Eukaryota.
DR   GeneTree; ENSGT00390000014835; -.
DR   HOGENOM; CLU_1890586_0_0_1; -.
DR   InParanoid; Q0VAF6; -.
DR   OMA; PYLPSNW; -.
DR   OrthoDB; 1433772at2759; -.
DR   PhylomeDB; Q0VAF6; -.
DR   TreeFam; TF338021; -.
DR   PathwayCommons; Q0VAF6; -.
DR   SignaLink; Q0VAF6; -.
DR   BioGRID-ORCS; 342898; 12 hits in 1071 CRISPR screens.
DR   GenomeRNAi; 342898; -.
DR   Pharos; Q0VAF6; Tbio.
DR   PRO; PR:Q0VAF6; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q0VAF6; protein.
DR   Bgee; ENSG00000179751; Expressed in body of pancreas and 85 other tissues.
DR   Genevisible; Q0VAF6; HS.
DR   GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   InterPro; IPR028137; Syncollin.
DR   PANTHER; PTHR17503; PTHR17503; 1.
DR   Pfam; PF15138; Syncollin; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Disulfide bond; Exocytosis; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..134
FT                   /note="Syncollin"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000295276"
FT   VARIANT         111
FT                   /note="L -> M (in dbSNP:rs2082416)"
FT                   /id="VAR_033284"
SQ   SEQUENCE   134 AA;  14405 MW;  1928D95BA3EC4274 CRC64;
     MSPLRPLLLA LALASVPCAQ GACPASADLK HSDGTRTCAK LYDKSDPYYE NCCGGAELSL
     ESGADLPYLP SNWANTASSL VVAPRCELTV WSRQGKAGKT HKFSAGTYPR LEEYRRGILG
     DWSNAISALY CRCS