SYD9_CAEEL
ID SYD9_CAEEL Reviewed; 554 AA.
AC A0A5E4M3Q4; A0A5E4LWX4; Q95PV3; Q95PV5; Q95PV6;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2019, sequence version 1.
DT 03-AUG-2022, entry version 11.
DE RecName: Full=Zinc finger protein syd-9 {ECO:0000305};
DE AltName: Full=Synapse defective protein 9 {ECO:0000312|WormBase:ZK867.1f};
GN Name=syd-9 {ECO:0000312|WormBase:ZK867.1f};
GN Synonyms=tag-239 {ECO:0000312|WormBase:ZK867.1f},
GN ztf-10 {ECO:0000312|WormBase:ZK867.1f};
GN ORFNames=ZK867.1 {ECO:0000312|WormBase:ZK867.1f};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=16803962; DOI=10.1073/pnas.0602073103;
RA Wang Y., Gracheva E.O., Richmond J., Kawano T., Couto J.M., Calarco J.A.,
RA Vijayaratnam V., Jin Y., Zhen M.;
RT "The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional
RT regulator for synaptic transmission.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:10450-10455(2006).
CC -!- FUNCTION: Plays a role in regulating synaptic function, probably by
CC modulation of endocytosis (PubMed:16803962). May be dispensable in
CC muscle for normal locomotion (PubMed:16803962). May be involved in
CC post-transcriptional mRNA processing, in parallel with unc-75
CC (PubMed:16803962). {ECO:0000269|PubMed:16803962,
CC ECO:0000303|PubMed:16803962}.
CC -!- INTERACTION:
CC A0A5E4M3Q4; Q9U2R6: nhr-91; NbExp=4; IntAct=EBI-329613, EBI-316939;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16803962}. Nucleus
CC speckle {ECO:0000269|PubMed:16803962}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=f {ECO:0000312|WormBase:ZK867.1f};
CC IsoId=A0A5E4M3Q4-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:ZK867.1b};
CC IsoId=A0A5E4M3Q4-2; Sequence=VSP_061149, VSP_061151;
CC Name=c {ECO:0000312|WormBase:ZK867.1c};
CC IsoId=A0A5E4M3Q4-3; Sequence=VSP_061150;
CC Name=d {ECO:0000312|WormBase:ZK867.1d};
CC IsoId=A0A5E4M3Q4-4; Sequence=VSP_061151;
CC Name=e {ECO:0000312|WormBase:ZK867.1e};
CC IsoId=A0A5E4M3Q4-5; Sequence=VSP_061150, VSP_061151;
CC -!- TISSUE SPECIFICITY: Expressed mainly in body wall muscles and ventral
CC cord motoneurons. {ECO:0000269|PubMed:16803962}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown, on an RNAi-sensitized
CC rrf-3 genetic background, causes sluggish movement, abnormal morphology
CC and low brood size, whereas when RNAi is targeted mainly at muscle,
CC animals move normally and have healthy body morphology.
CC {ECO:0000269|PubMed:16803962}.
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DR EMBL; BX284606; CCD68083.1; -; Genomic_DNA.
DR EMBL; BX284606; CCD68084.1; -; Genomic_DNA.
DR EMBL; BX284606; CCD68085.1; -; Genomic_DNA.
DR EMBL; BX284606; VVC12416.1; -; Genomic_DNA.
DR EMBL; BX284606; VVC12417.1; -; Genomic_DNA.
DR RefSeq; NP_509213.1; NM_076812.4.
DR RefSeq; NP_509214.2; NM_076813.4.
DR RefSeq; NP_509216.1; NM_076815.4.
DR AlphaFoldDB; A0A5E4M3Q4; -.
DR IntAct; A0A5E4M3Q4; 4.
DR STRING; 6239.ZK867.1c; -.
DR EnsemblMetazoa; ZK867.1b.1; ZK867.1b.1; WBGene00044068. [A0A5E4M3Q4-2]
DR EnsemblMetazoa; ZK867.1b.2; ZK867.1b.2; WBGene00044068. [A0A5E4M3Q4-2]
DR EnsemblMetazoa; ZK867.1b.3; ZK867.1b.3; WBGene00044068. [A0A5E4M3Q4-2]
DR EnsemblMetazoa; ZK867.1b.4; ZK867.1b.4; WBGene00044068. [A0A5E4M3Q4-2]
DR EnsemblMetazoa; ZK867.1c.1; ZK867.1c.1; WBGene00044068. [A0A5E4M3Q4-3]
DR EnsemblMetazoa; ZK867.1d.1; ZK867.1d.1; WBGene00044068. [A0A5E4M3Q4-4]
DR EnsemblMetazoa; ZK867.1e.1; ZK867.1e.1; WBGene00044068. [A0A5E4M3Q4-5]
DR EnsemblMetazoa; ZK867.1f.1; ZK867.1f.1; WBGene00044068. [A0A5E4M3Q4-1]
DR GeneID; 180985; -.
DR UCSC; ZK867.1c; c. elegans.
DR CTD; 180985; -.
DR WormBase; ZK867.1b; CE28198; WBGene00044068; syd-9.
DR WormBase; ZK867.1c; CE35819; WBGene00044068; syd-9.
DR WormBase; ZK867.1d; CE29653; WBGene00044068; syd-9.
DR WormBase; ZK867.1e; CE28199; WBGene00044068; syd-9.
DR WormBase; ZK867.1f; CE53637; WBGene00044068; syd-9.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161335; -.
DR HOGENOM; CLU_1887607_0_0_1; -.
DR OMA; NSHAINN; -.
DR OrthoDB; 1607436at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00044068; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; A0A5E4M3Q4; baseline and differential.
DR GO; GO:0016607; C:nuclear speck; IDA:WormBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..554
FT /note="Zinc finger protein syd-9"
FT /id="PRO_0000453460"
FT ZN_FING 20..43
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 65..87
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 93..116
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 387..410
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 136..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..317
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061149"
FT VAR_SEQ 47..63
FT /note="Missing (in isoform c and isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_061150"
FT VAR_SEQ 449..554
FT /note="ELKAQQAATPRVEQALTYIDSRVGKLERSLETALNSIYTLVQLQTGMTSSVN
FT RLREDSTKNFSDLKTRMEMSLSPIKPFQQRFSRERSSSSSVERSPSRERSRSPL -> T
FT NVY (in isoform b, isoform d and isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_061151"
SQ SEQUENCE 554 AA; 60211 MW; AE104FA4F022C712 CRC64;
MSVCVSPLVQ ATILMTEESL TCPQCPKSFS STKLLQQHQQ MFHTDKSVLL SLKSTDAPVG
MDRAFICETC GKAFRFRSNL AEHRSVHTAL KPYVCKFCGK SSRLKGNLTK HILKHHKKEQ
NEAIAKDDII VKKAPKIVTK DNGPTTNGST PTTSTATPSV ITVSSALASS NGHNNNNNNH
AVNNNLRTIK MELEDPDYNL IAKSAPTPVV SKIVATHTVT PRSRPTPKDI KEILETIAPS
VGVSETPEEM CLLPKDASSE SDRSVLISLG FDFGSTLSLN HQQLQQVVRE LKGELSISPD
TVQSDHSDDF EQDSPPPMAI ANISTVGGEA TLAAMIVAAT NASGQRGDGT PDSTDTQKGC
SPQRELSPES DPSTSSGDSC PSPPKMLHCK ECGTLVRKSS HLPIHMTMSH GYPPPLVAAP
VEEKPAPEQP VNASSLHNEL RVISNAICEL KAQQAATPRV EQALTYIDSR VGKLERSLET
ALNSIYTLVQ LQTGMTSSVN RLREDSTKNF SDLKTRMEMS LSPIKPFQQR FSRERSSSSS
VERSPSRERS RSPL
