ID   BIOM_RHIEC              Reviewed;         224 AA.
AC   Q2KBP5; Q6GUB2;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Biotin transport ATP-binding protein BioM;
DE            EC=7.6.2.-;
DE   AltName: Full=Biotin ECF transporter A component BioM;
GN   Name=bioM; OrderedLocusNames=RHE_CH00930;
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, AND INDUCTION.
RC   STRAIN=CE3;
RX   PubMed=16099603; DOI=10.1016/j.femsle.2005.07.020;
RA   Guillen-Navarro K., Araiza G., Garcia-de los Santos A., Mora Y., Dunn M.F.;
RT   "The Rhizobium etli bioMNY operon is involved in biotin transport.";
RL   FEMS Microbiol. Lett. 250:209-219(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251;
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC   -!- FUNCTION: Involved in biotin uptake. {ECO:0000305|PubMed:16099603}.
CC   -!- SUBUNIT: Part of a biotin transporter complex composed of BioM, BioN
CC       and BioY. {ECO:0000305|PubMed:16099603}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- INDUCTION: Expression is repressed by biotin.
CC       {ECO:0000269|PubMed:16099603}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AY644481; AAT52196.1; -; Genomic_DNA.
DR   EMBL; CP000133; ABC89741.1; -; Genomic_DNA.
DR   RefSeq; WP_011424277.1; NC_007761.1.
DR   AlphaFoldDB; Q2KBP5; -.
DR   SMR; Q2KBP5; -.
DR   STRING; 347834.RHE_CH00930; -.
DR   TCDB; 3.A.1.25.1; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; ABC89741; ABC89741; RHE_CH00930.
DR   GeneID; 61479384; -.
DR   KEGG; ret:RHE_CH00930; -.
DR   eggNOG; COG1122; Bacteria.
DR   HOGENOM; CLU_000604_1_22_5; -.
DR   OMA; YALELCP; -.
DR   Proteomes; UP000001936; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd03225; ABC_cobalt_CbiO_domain1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015856; ABC_transpr_CbiO/EcfA_su.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport.
FT   CHAIN           1..224
FT                   /note="Biotin transport ATP-binding protein BioM"
FT                   /id="PRO_0000416408"
FT   DOMAIN          3..224
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   CONFLICT        47
FT                   /note="I -> V (in Ref. 1; AAT52196)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        63..82
FT                   /note="RDTADEKTVVTDVGFIFQSP -> PSIRPTRRRLSPHVGLHLSSRE (in
FT                   Ref. 1; AAT52196)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        93
FT                   /note="D -> Y (in Ref. 1; AAT52196)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        133
FT                   /note="L -> A (in Ref. 1; AAT52196)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   224 AA;  23870 MW;  25631F623AE6CA59 CRC64;
     MNIQFESAGV SFGARVALEP LTLAITGKRI GVIGLNGSGK TTFARLINGL TKPTTGRVIV
     NGRDTADEKT VVTDVGFIFQ SPQNQIILPI VKDDIAFGLK RRGLSKAEIE ARVEGVLARF
     GAEALADRRA HELSGGELQV AALCSVLATG PGILILDEPT NQLDLKNRAL VERIIAGLPE
     SAIVITHDLE LIAGFERVLV FHEGRLAADE PAAEAIARYR EIAA