ID   ABLB2_PHYPN             Reviewed;         108 AA.
AC   W2PED7;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=RxLR effector protein PPTG_18954 {ECO:0000303|PubMed:30984224};
DE   AltName: Full=Avrblb2-like effector PPTG_18954 {ECO:0000303|PubMed:30984224};
DE   Flags: Precursor;
GN   ORFNames=PPTG_18954;
OS   Phytophthora parasitica (strain INRA-310).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=761204;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=INRA-310;
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA   Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA   Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA   Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA   Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=INRA-310;
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA   Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   INTERACTION WITH HOST CALMODULIN, AND FUNCTION.
RX   PubMed=30984224; DOI=10.3389/fpls.2019.00374;
RA   Naveed Z.A., Bibi S., Ali G.S.;
RT   "The Phytophthora RXLR Effector Avrblb2 Modulates Plant Immunity by
RT   Interfering With Ca2+ Signaling Pathway.";
RL   Front. Plant Sci. 10:374-374(2019).
CC   -!- FUNCTION: Secreted effector that associates with calmodulin to
CC       interfere with plant defense-associated calcium signaling in hosts.
CC       {ECO:0000269|PubMed:30984224}.
CC   -!- SUBUNIT: Interacts with the host calmodulin.
CC       {ECO:0000269|PubMed:30984224}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30984224}. Host cell
CC       {ECO:0000269|PubMed:30984224}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:30984224}.
CC   -!- DOMAIN: The amino acids 79-83 in the C-terminal region of are important
CC       for binding to host calmodulin. {ECO:0000250|UniProtKB:D0P1A8}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KI669657; ETM99216.1; -; Genomic_DNA.
DR   RefSeq; XP_008915529.1; XM_008917281.1.
DR   AlphaFoldDB; W2PED7; -.
DR   EnsemblProtists; ETM99216; ETM99216; PPTG_18954.
DR   GeneID; 20187778; -.
DR   VEuPathDB; FungiDB:PPTG_18954; -.
DR   OMA; IAHTTNK; -.
DR   Proteomes; UP000018817; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..108
FT                   /note="RxLR effector protein PPTG_18954"
FT                   /id="PRO_5004821408"
FT   MOTIF           45..58
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:30984224"
FT   MOTIF           79..83
FT                   /note="Calmodulin-binding motif"
FT                   /evidence="ECO:0000250|UniProtKB:D0P1A8"
SQ   SEQUENCE   108 AA;  11395 MW;  5046699B78AD7FC2 CRC64;
     MRSVFYVALV FAVLARSSTV AAFPHTDESQ LLAVTSPDSA THTKRSLRAA GQEVVQSTGN
     GNGGIFKSTL TSINKVVHKP EIKLGGLIEK AKIAQAAKAF KNKATGKK