BIOW_SULAA
ID BIOW_SULAA Reviewed; 245 AA.
AC C1DW75;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=6-carboxyhexanoate--CoA ligase {ECO:0000255|HAMAP-Rule:MF_00668};
DE EC=6.2.1.14 {ECO:0000255|HAMAP-Rule:MF_00668};
DE AltName: Full=Pimeloyl-CoA synthase {ECO:0000255|HAMAP-Rule:MF_00668};
GN Name=bioW {ECO:0000255|HAMAP-Rule:MF_00668}; OrderedLocusNames=SULAZ_1395;
OS Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825).
OC Bacteria; Aquificae; Aquificales; Hydrogenothermaceae;
OC Sulfurihydrogenibium.
OX NCBI_TaxID=204536;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Az-Fu1 / DSM 15241 / OCM 825;
RX PubMed=19136599; DOI=10.1128/jb.01645-08;
RA Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S.,
RA Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A.,
RA Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.;
RT "Complete and draft genome sequences of six members of the Aquificales.";
RL J. Bacteriol. 191:1992-1993(2009).
CC -!- FUNCTION: Catalyzes the transformation of pimelate into pimeloyl-CoA
CC with concomitant hydrolysis of ATP to AMP. {ECO:0000255|HAMAP-
CC Rule:MF_00668}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + heptanedioate = 6-carboxyhexanoyl-CoA + AMP +
CC diphosphate; Xref=Rhea:RHEA:14781, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:36165, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57360, ChEBI:CHEBI:456215; EC=6.2.1.14;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00668};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00668};
CC -!- PATHWAY: Metabolic intermediate metabolism; pimeloyl-CoA biosynthesis;
CC pimeloyl-CoA from pimelate: step 1/1. {ECO:0000255|HAMAP-
CC Rule:MF_00668}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00668}.
CC -!- SIMILARITY: Belongs to the BioW family. {ECO:0000255|HAMAP-
CC Rule:MF_00668}.
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DR EMBL; CP001229; ACN98309.1; -; Genomic_DNA.
DR RefSeq; WP_012673634.1; NC_012438.1.
DR AlphaFoldDB; C1DW75; -.
DR SMR; C1DW75; -.
DR STRING; 204536.SULAZ_1395; -.
DR EnsemblBacteria; ACN98309; ACN98309; SULAZ_1395.
DR KEGG; saf:SULAZ_1395; -.
DR eggNOG; COG1424; Bacteria.
DR HOGENOM; CLU_076858_0_0_0; -.
DR OMA; LCWSDDP; -.
DR OrthoDB; 1268552at2; -.
DR UniPathway; UPA00999; UER00351.
DR Proteomes; UP000001369; Chromosome.
DR GO; GO:0042410; F:6-carboxyhexanoate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00668; BioW; 1.
DR InterPro; IPR005499; BioW.
DR Pfam; PF03744; BioW; 1.
DR TIGRFAMs; TIGR01204; bioW; 1.
PE 3: Inferred from homology;
KW ATP-binding; Biotin biosynthesis; Ligase; Magnesium; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..245
FT /note="6-carboxyhexanoate--CoA ligase"
FT /id="PRO_0000412089"
SQ SEQUENCE 245 AA; 27940 MW; 6A4A75479A9D78EF CRC64;
MKEYFSVKMR ASLQGRHVSG AERIVLKEDL PTVISQLSQR PKEYDSLNIK VEKINDLNYI
EKSLNVKTIN VKDWIEGNKV AVEILQNQGV DKKIAEKYIN LIHQGAVNGE NMRGAMIVNL
SGERVEKDKT RGIRTVNIDF EDRKAITELL KEKGYTERTV DALALATKTL NHPDIVAEYC
ISDDPSYTTG YVATKTTYYR INPLKQLSNE KGGRIYFVKD TANIEDIYQY LESEAFLIKQ
LGDLQ