ID   BIOX_LYSSH              Reviewed;         166 AA.
AC   P22821;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Protein BioX;
GN   Name=bioX;
OS   Lysinibacillus sphaericus (Bacillus sphaericus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX   NCBI_TaxID=1421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 10208 / DSM 5019 / NBRC 3525 / NCIMB 11935 / NRS 966 / 1911;
RX   PubMed=2110099; DOI=10.1016/0378-1119(90)90496-e;
RA   Gloeckler R., Ohsawa I., Speck D., Ledoux C., Bernard S., Zinsius M.,
RA   Villeval D., Kisou T., Kamogawa K., Lemoine Y.;
RT   "Cloning and characterization of the Bacillus sphaericus genes controlling
RT   the bioconversion of pimelate into dethiobiotin.";
RL   Gene 87:63-70(1990).
CC   -!- FUNCTION: Does not seem to be a permease of pimelate. Its role in
CC       biotin synthesis is not clear.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
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DR   EMBL; M29291; AAA22269.1; -; Genomic_DNA.
DR   PIR; JQ0510; JQ0510.
DR   RefSeq; WP_024362855.1; NZ_UFSZ01000001.1.
DR   AlphaFoldDB; P22821; -.
DR   GeneID; 48278544; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Biotin biosynthesis; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..166
FT                   /note="Protein BioX"
FT                   /id="PRO_0000064930"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   166 AA;  17706 MW;  B48479955F339023 CRC64;
     MRKFSTYDLA QISLLACLII VTGMFKIPTG IPGSEFQLSA PIAVAIAAVF GFKRYFLAGI
     IASLILFLLG IHSILNVEIS IIFRLTVGLI IVLLGTSIPV LVVAGPIGTM VARLGLAFTL
     GTPFLPLFVL AIPGMVITAV SVYPITKMLY AINKKVAGDH HVRNVL