BIOY_BACSU
ID BIOY_BACSU Reviewed; 186 AA.
AC O07620; Q796T2;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Probable biotin transporter BioY;
GN Name=bioY; Synonyms=yhfU; OrderedLocusNames=BSU10370;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA Venema G., Bron S.;
RT "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL Microbiology 144:859-875(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP INDUCTION, AND PROBABLE OPERON STRUCTURE.
RC STRAIN=168 / PY79;
RX PubMed=11717296; DOI=10.1128/jb.183.24.7371-7380.2001;
RA Lee J.M., Zhang S., Saha S., Santa Anna S., Jiang C., Perkins J.;
RT "RNA expression analysis using an antisense Bacillus subtilis genome
RT array.";
RL J. Bacteriol. 183:7371-7380(2001).
RN [4]
RP IDENTIFICATION.
RX PubMed=12368242; DOI=10.1101/gr.314502;
RA Rodionov D.A., Mironov A.A., Gelfand M.S.;
RT "Conservation of the biotin regulon and the BirA regulatory signal in
RT Eubacteria and Archaea.";
RL Genome Res. 12:1507-1516(2002).
CC -!- FUNCTION: Probable biotin transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Repressed by presence of biotin, under control of BirA.
CC Probably part of the bioY-yhfST operon. {ECO:0000269|PubMed:11717296}.
CC -!- SIMILARITY: Belongs to the BioY family. {ECO:0000305}.
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DR EMBL; Y14084; CAA74544.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12877.1; -; Genomic_DNA.
DR PIR; B69832; B69832.
DR RefSeq; NP_388918.1; NC_000964.3.
DR RefSeq; WP_003233151.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; O07620; -.
DR SMR; O07620; -.
DR STRING; 224308.BSU10370; -.
DR TCDB; 2.A.88.1.9; the vitamin uptake transporter (vut) family.
DR PaxDb; O07620; -.
DR EnsemblBacteria; CAB12877; CAB12877; BSU_10370.
DR GeneID; 939321; -.
DR KEGG; bsu:BSU10370; -.
DR PATRIC; fig|224308.43.peg.1082; -.
DR eggNOG; COG1268; Bacteria.
DR InParanoid; O07620; -.
DR OMA; AGYLWSY; -.
DR PhylomeDB; O07620; -.
DR BioCyc; BSUB:BSU10370-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015225; F:biotin transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003784; BioY.
DR PANTHER; PTHR34295; PTHR34295; 1.
DR Pfam; PF02632; BioY; 1.
DR PIRSF; PIRSF016661; BioY; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..186
FT /note="Probable biotin transporter BioY"
FT /id="PRO_0000360645"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 186 AA; 20010 MW; 145D4AD79C296CD6 CRC64;
MLKLIDMMHI AIFTALMAVL GFMPPLFLSF TPVPITLQTL GVMLAGSILR PKSAFLSQLV
FLLLVAFGAP LLPGGRGGFG VFFGPSAGFL IAYPLASWLI SLAANRLRKV TVLRLFFTHI
VFGIIFIYLL GIPVQAFIMH IDLSQAAFMS LAYVPGDLIK AAVSAFLAIK ITQALSLSDT
MFTKGG
