ID   BIOY_PYRHO              Reviewed;         162 AA.
AC   O57898;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Probable biotin transporter BioY;
GN   Name=bioY; OrderedLocusNames=PH0159;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- FUNCTION: Probable biotin transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BioY family. {ECO:0000305}.
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DR   EMBL; BA000001; BAA29228.1; -; Genomic_DNA.
DR   PIR; E71237; E71237.
DR   RefSeq; WP_010884269.1; NC_000961.1.
DR   AlphaFoldDB; O57898; -.
DR   SMR; O57898; -.
DR   STRING; 70601.3256545; -.
DR   EnsemblBacteria; BAA29228; BAA29228; BAA29228.
DR   GeneID; 1444051; -.
DR   KEGG; pho:PH0159; -.
DR   eggNOG; arCOG02986; Archaea.
DR   OMA; AGYLWSY; -.
DR   OrthoDB; 92598at2157; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015225; F:biotin transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR003784; BioY.
DR   PANTHER; PTHR34295; PTHR34295; 1.
DR   Pfam; PF02632; BioY; 1.
DR   PIRSF; PIRSF016661; BioY; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..162
FT                   /note="Probable biotin transporter BioY"
FT                   /id="PRO_0000144149"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   162 AA;  17000 MW;  5955323E998B7FC4 CRC64;
     MKAKEVSLVA LFVALTSVGA QISVSIGPVP LTLQVFFVIL AGLVLGPKLG FLSILIYDIL
     GALGIPVFAG FSGGIAHILG PTGGYIIAFP IATFIAGLGR GKVRYLTSLM GLLVIYLIGW
     MWLARFVGFN KAFILGVLPF IVPDIVKAAT AVIIAERLQG NT