ID   BIOY_TREPA              Reviewed;         271 AA.
AC   O83256;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Probable biotin transporter BioY;
GN   Name=bioY; OrderedLocusNames=TP_0228;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Probable biotin transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BioY family. {ECO:0000305}.
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DR   EMBL; AE000520; AAC65216.1; -; Genomic_DNA.
DR   PIR; B71351; B71351.
DR   AlphaFoldDB; O83256; -.
DR   SMR; O83256; -.
DR   IntAct; O83256; 1.
DR   STRING; 243276.TPANIC_0228; -.
DR   EnsemblBacteria; AAC65216; AAC65216; TP_0228.
DR   KEGG; tpa:TP_0228; -.
DR   eggNOG; COG1268; Bacteria.
DR   HOGENOM; CLU_077931_3_0_12; -.
DR   OMA; AGYLWSY; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015225; F:biotin transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR003784; BioY.
DR   PANTHER; PTHR34295; PTHR34295; 1.
DR   Pfam; PF02632; BioY; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..271
FT                   /note="Probable biotin transporter BioY"
FT                   /id="PRO_0000144147"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   271 AA;  28773 MW;  462EE7EAA4524A2D CRC64;
     MHRTEPTINC VHDGTRSLHL SIDTTRALPA HSGNEPTRTH LAAVRVSLLK TIPVAPPKIL
     KDSSFRVTLR IDPSEEYCTM HRSKSLAFVA LFAALISSSA LVSIPLKPVP LVLQNAAAVL
     TGLLLGPRDG ALAVLSFLGA GLLGLPVFSG GRGGYTALFA PTGGFLLGYI LAATLAGAIA
     QHHRLSCTPP RGGGRALLLW IRLTVATLVG FLSIYSIGLP VLGYVLGLRT GELMLGVFLP
     FFLADTLKIA LVVLLAHHLA PTVRRHLYRH G