ID   BIPB_BURM7              Reviewed;         620 AA.
AC   A3MCG8;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Translocator protein BipB;
GN   Name=bipB; OrderedLocusNames=BMA10247_A0753;
OS   Burkholderia mallei (strain NCTC 10247).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=320389;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 10247;
RX   PubMed=20333227; DOI=10.1093/gbe/evq003;
RA   Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA   Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA   Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA   Nierman W.C.;
RT   "Continuing evolution of Burkholderia mallei through genome reduction and
RT   large-scale rearrangements.";
RL   Genome Biol. Evol. 2:102-116(2010).
CC   -!- FUNCTION: Plays a role in the bacterium-induced formation of
CC       multinucleated giant cell (MNGC), which is formed after host cell
CC       fusion, as well as in the intercellular spreading of bacteria and in
CC       the induction of apoptosis in macrophages. May act in concert with
CC       other effector proteins to induce fusion of host cell membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host membrane
CC       {ECO:0000250}. Note=Secreted via the bsa type III secretion system, and
CC       probably inserted into host membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the invasin protein B family. {ECO:0000305}.
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DR   EMBL; CP000547; ABO03246.1; -; Genomic_DNA.
DR   RefSeq; WP_004533397.1; NZ_CP007801.1.
DR   AlphaFoldDB; A3MCG8; -.
DR   SMR; A3MCG8; -.
DR   GeneID; 56597877; -.
DR   KEGG; bmaz:BM44_4992; -.
DR   KEGG; bmn:BMA10247_A0753; -.
DR   PATRIC; fig|320389.8.peg.5728; -.
DR   OMA; KFASHSI; -.
DR   Proteomes; UP000002284; Chromosome II.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR032391; SipB_N.
DR   InterPro; IPR006972; SseC.
DR   InterPro; IPR003895; T3SS_invasion_prot_B.
DR   Pfam; PF04888; SseC; 1.
DR   Pfam; PF16535; T3SSipB; 1.
DR   PRINTS; PR01375; BACINVASINB.
PE   3: Inferred from homology;
KW   Coiled coil; Host membrane; Membrane; Secreted; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..620
FT                   /note="Translocator protein BipB"
FT                   /id="PRO_0000343987"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          58..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          309..339
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        64..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   620 AA;  64680 MW;  DCAFE3579309EFAC CRC64;
     MSSGVQGGPA ANANAYQTHP LRDAASALGT LSPQAYVDVV SAAQRNFLER MSQLASEQCD
     AQPAAHDARL DDRPALRAPQ ERDAPPLGAS DTGSRASGAA KLTELLGVLM SVISASSLDE
     LKQRSDIWNQ MSKAAQDNLS RLSDAFQRAT DEAKAAADAA EQAAAAAKQA GADAKAADAA
     VDAAQKRYDD AVKQGLPDDR LQSLKAALEQ ARQQAGDAHG RADALQADAT KKLDAASALA
     TQARACEQQV DDAVNQATQQ YGASASLRTP QSPRLSGAAE LTAVLGKLQE LISSGNVKEL
     ESKQKLFTEM QAKREAELQK KSDEYQAQVK KAEEMQKTMG CIGKIVGWVI TAVSFAAAAF
     TGGASLALAA VGLALAVGDE ISRATTGVSF MDKLMQPVMD AILKPLMEMI SSLITKALVA
     CGVDQQKAEL AGAILGAVVT GVALVAAAFV GASAVKAVAS KVIDAMAGQL TKLMDSAIGK
     MLVQLIEKFS EKSGLQALGS RTATAMTRMR RAIGVEAKED GMLLANRFEK AGTVMNVGNQ
     VSQAAGGIVV GVERAKAMGL LADVKEAMYD IKLLGDLLKQ AVDAFAEHNR VLAQLMQQMS
     DAGEMQTSTG KLILRNARAV