ID   BIPB_BURTA              Reviewed;         624 AA.
AC   Q2T711;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Translocator protein BipB;
GN   Name=bipB; OrderedLocusNames=BTH_II0841;
OS   Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 /
OS   E264).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=271848;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700388 / DSM 13276 / CIP 106301 / E264;
RX   PubMed=16336651; DOI=10.1186/1471-2164-6-174;
RA   Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C.,
RA   DeShazer D.;
RT   "Bacterial genome adaptation to niches: divergence of the potential
RT   virulence genes in three Burkholderia species of different survival
RT   strategies.";
RL   BMC Genomics 6:174-174(2005).
CC   -!- FUNCTION: Plays a role in the bacterium-induced formation of
CC       multinucleated giant cell (MNGC), which is formed after host cell
CC       fusion, as well as in the intercellular spreading of bacteria and in
CC       the induction of apoptosis in macrophages. May act in concert with
CC       other effector proteins to induce fusion of host cell membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host membrane
CC       {ECO:0000250}. Note=Secreted via the bsa type III secretion system, and
CC       probably inserted into host membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the invasin protein B family. {ECO:0000305}.
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DR   EMBL; CP000085; ABC34967.1; -; Genomic_DNA.
DR   RefSeq; WP_011401047.1; NZ_CP008786.1.
DR   AlphaFoldDB; Q2T711; -.
DR   SMR; Q2T711; -.
DR   PRIDE; Q2T711; -.
DR   EnsemblBacteria; ABC34967; ABC34967; BTH_II0841.
DR   KEGG; bte:BTH_II0841; -.
DR   HOGENOM; CLU_027418_0_0_4; -.
DR   OMA; KFASHSI; -.
DR   OrthoDB; 483748at2; -.
DR   Proteomes; UP000001930; Chromosome II.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR032391; SipB_N.
DR   InterPro; IPR006972; SseC.
DR   InterPro; IPR003895; T3SS_invasion_prot_B.
DR   Pfam; PF04888; SseC; 1.
DR   Pfam; PF16535; T3SSipB; 1.
DR   PRINTS; PR01375; BACINVASINB.
PE   3: Inferred from homology;
KW   Coiled coil; Host membrane; Membrane; Secreted; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..624
FT                   /note="Translocator protein BipB"
FT                   /id="PRO_0000343994"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          54..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          313..343
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        64..82
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  65044 MW;  EF362C3A437D47E4 CRC64;
     MSSGVQGGSA ANANAYQTHP LRDAASALGT LSPQAYVDVV SAAQRNFLER MSRLASEQCD
     AQPVTDDARL DRLDDKPALR APRSDAAHAA DGNARGNGGA SGAAKLTELL GVLMSVISAS
     SLDELRQRSD IWNQMSKAAQ DNLTSLSDKF QCATDDAKAA TDAAERAAAA AKQAAADAKA
     ADAAADAAQK RYDDAMKQGL PDDQLKTLQA ALEQAKQQAG DAHARADALQ ADAAGKLDAA
     TALATQAREW EQQIDDAVNQ ASRQYGASAS LRTPPSPKLS GAAELTAVLG KLQELISSGN
     VKELESKQKL FTEMQAKREA ELQKKSDEYQ EQVKKAEEMQ KTMGCIGKIV GWVITAVSFA
     AAAFTGGASL ALAAVGLALA VGDEISRATT GVSFMDKLMQ PVMDAILKPL MEVISSLITK
     ALVACGVDQQ KAELAGAILG AVVTGVALVA AAFVGASAVK AVASKVIDAV AGQLTKLMDS
     AIGKMLVQLI EKFSEKSGLQ ALGSRTATAM TRMRRAIGVE AKEDGMLLAN RFEKAGTVMN
     VGNQVSQAAG GIVVGVERAK AMGLLADVKE AMYDIKLLGD LLKQAVESFA EHNRALAQLM
     QQMSDAGEMQ TATGKLILRN ARAV