ID   BIPC_BURPS              Reviewed;         419 AA.
AC   Q63K35;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Effector protein BipC;
GN   Name=bipC; OrderedLocusNames=BPSS1531;
OS   Burkholderia pseudomallei (strain K96243).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=272560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND IMMUNOGENICITY.
RC   STRAIN=K96243, PHLS 79, and PHLS 91;
RX   PubMed=17995960; DOI=10.1111/j.1574-695x.2007.00345.x;
RA   Druar C., Yu F., Barnes J.L., Okinaka R.T., Chantratita N., Beg S.,
RA   Stratilo C.W., Olive A.J., Soltes G., Russell M.L., Limmathurotsakul D.,
RA   Norton R.E., Ni S.X., Picking W.D., Jackson P.J., Stewart D.I.H.,
RA   Tsvetnitsky V., Picking W.L., Cherwonogrodzky J.W., Ketheesan N.,
RA   Peacock S.J., Wiersma E.J.;
RT   "Evaluating Burkholderia pseudomallei Bip proteins as vaccines and Bip
RT   antibodies as detection agents.";
RL   FEMS Immunol. Med. Microbiol. 52:78-87(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D.,
RA   Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A.,
RA   Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A.,
RA   Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z.,
RA   Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S.,
RA   Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M.,
RA   Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT   pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Note=Secreted via the bsa
CC       type III secretion system.
CC   -!- MISCELLANEOUS: Human meliodoisis patients have detectable antibody
CC       response to BipC. However, BipC does not act as a protective antigen.
CC   -!- SIMILARITY: Belongs to the invasin protein C family. {ECO:0000305}.
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DR   EMBL; EF428329; ABO26349.1; -; Genomic_DNA.
DR   EMBL; EF428332; ABO26355.1; -; Genomic_DNA.
DR   EMBL; EF436254; ABO28815.1; -; Genomic_DNA.
DR   EMBL; BX571966; CAH39004.1; -; Genomic_DNA.
DR   RefSeq; WP_004203135.1; NZ_CP009537.1.
DR   RefSeq; YP_111537.1; NC_006351.1.
DR   AlphaFoldDB; Q63K35; -.
DR   STRING; 272560.BPSS1531; -.
DR   EnsemblBacteria; CAH39004; CAH39004; BPSS1531.
DR   GeneID; 56597876; -.
DR   KEGG; bps:BPSS1531; -.
DR   PATRIC; fig|272560.51.peg.4886; -.
DR   OMA; MEIQNTK; -.
DR   PHI-base; PHI:5321; -.
DR   PHI-base; PHI:7309; -.
DR   Proteomes; UP000000605; Chromosome 2.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005427; BacInvasinC.
DR   Pfam; PF09599; IpaC_SipC; 1.
DR   TIGRFAMs; TIGR02101; IpaC_SipC; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Virulence.
FT   CHAIN           1..419
FT                   /note="Effector protein BipC"
FT                   /id="PRO_0000344001"
FT   REGION          62..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          338..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   419 AA;  44323 MW;  53F278B1D41D7845 CRC64;
     MSIGVQSSGI NISHAELSRL VDAGKSEQGD KAVRDDGRAL ARADAALAAV VGERVAARRD
     AVAGSGAQRV ELARPKPDAQ TRATDRRTVS GLEREHKRLA ASQTPRVTGM HDALVQRHVS
     LDGAKAAHGE GVKRAAGDAP RAAADAPQRF AFADDKAFDA MLALGAAMQK NVQSDLAMQG
     KLTMLAHDAM MSAAAQDRSI GAAQMTAAIA GGALQATTSL GGAMQQMKSL STKSMSIEKE
     LKPQAELKQF HAEQALELRG INKPVLSNDE VSHVKIKRDT GETVRHEIDH GGERMSDEHA
     SVLAQEAPAR QHRIDMHGMR HEENLVKAGR QQMKGDLLQS GGQIGKNQID GASAQQQGAD
     RAEQKEDENA QQTAMAAAST RDEAAHRSRE AAQKAIDAAK SQVANDNAVA AQVAGNLRT