ID   ABL_CALVI               Reviewed;          74 AA.
AC   P11681;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Tyrosine-protein kinase ABL;
DE            EC=2.7.10.2;
DE   Flags: Fragment;
GN   Name=ABL;
OS   Calliphora vicina (Blue blowfly) (Calliphora erythrocephala).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Calliphorinae; Calliphora.
OX   NCBI_TaxID=7373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3125084; DOI=10.1016/0378-1119(87)90267-8;
RA   Durica D.S., Restrepo M.A., Thomas T.L., Beckingham K.;
RT   "Isolation and characterization of abl gene sequences in Calliphora
RT   erythrocephala.";
RL   Gene 59:63-76(1987).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. ABL subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR   EMBL; M18427; AAA28232.1; -; Genomic_DNA.
DR   PIR; A29597; A29597.
DR   AlphaFoldDB; P11681; -.
DR   SMR; P11681; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR033221; ABL1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   PANTHER; PTHR24418:SF162; PTHR24418:SF162; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Transferase;
KW   Tyrosine-protein kinase.
FT   CHAIN           <1..>74
FT                   /note="Tyrosine-protein kinase ABL"
FT                   /id="PRO_0000088053"
FT   DOMAIN          <1..>74
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   MOTIF           50..74
FT                   /note="Kinase activation loop"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        32
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10028"
FT   NON_TER         1
FT   NON_TER         74
SQ   SEQUENCE   74 AA;  8303 MW;  DBF86E8D35001CCA CRC64;
     RETLDAVALL YMATQIASGM SYLEARNYIH RDLAARNCLV GDNKLVKVAD FGLARLMRDD
     TYTAHAGAKF PIKW