ID   SYF1_ASHGO              Reviewed;         803 AA.
AC   Q75EF0;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Pre-mRNA-splicing factor SYF1;
GN   Name=SYF1; OrderedLocusNames=AAR131W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 355.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; AE016814; AAS50497.2; -; Genomic_DNA.
DR   RefSeq; NP_982673.2; NM_208026.2.
DR   AlphaFoldDB; Q75EF0; -.
DR   SMR; Q75EF0; -.
DR   STRING; 33169.AAS50497; -.
DR   EnsemblFungi; AAS50497; AAS50497; AGOS_AAR131W.
DR   GeneID; 4618715; -.
DR   KEGG; ago:AGOS_AAR131W; -.
DR   eggNOG; KOG2047; Eukaryota.
DR   HOGENOM; CLU_007736_0_0_1; -.
DR   InParanoid; Q75EF0; -.
DR   OMA; FLMQQPL; -.
DR   Proteomes; UP000000591; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00386; HAT; 8.
DR   SUPFAM; SSF48452; SSF48452; 3.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..803
FT                   /note="Pre-mRNA-splicing factor SYF1"
FT                   /id="PRO_0000205725"
FT   REPEAT          3..34
FT                   /note="HAT 1"
FT   REPEAT          35..67
FT                   /note="HAT 2"
FT   REPEAT          79..111
FT                   /note="HAT 3"
FT   REPEAT          113..147
FT                   /note="HAT 4"
FT   REPEAT          393..425
FT                   /note="HAT 5"
FT   REPEAT          427..463
FT                   /note="HAT 6"
FT   REPEAT          482..519
FT                   /note="HAT 7"
FT   REPEAT          525..557
FT                   /note="HAT 8"
FT   REPEAT          559..593
FT                   /note="HAT 9"
FT   REPEAT          596..631
FT                   /note="HAT 10"
FT   REPEAT          633..668
FT                   /note="HAT 11"
FT   REPEAT          670..704
FT                   /note="HAT 12"
FT   REPEAT          708..740
FT                   /note="HAT 13"
SQ   SEQUENCE   803 AA;  91802 MW;  8AF52074E9EF0B6A CRC64;
     MDEFVTAEDL VHEYSVLQEP DSVVNWSRYI AAKRDDPCSV SWVYERCLQA LPAQWEVWRE
     YLQFRMRLLD GVCAVQHAAE FEKVNRLFWR CVEHNAAVVE AWRLFLGHAQ RQGALALVRQ
     VVDAALRGVG LAKHRTVWED VVAYIEELLP AEETDLGEEQ DLHELVRGAL FGGAGAEDAG
     ADIWSSAMLR RYIQVAEDAE AVLALLQRTH DYATVVAVYE KHVLPVTRAK HKGRQSYESQ
     FRYLVALDHT GATAKLEDAV ARCAQLFPER APSLTIFLAK HYVKQGNYNR CTDVLTDSLK
     HTAKSSEFAS LYDFLVVFEE SLIEVVLEHL QEHPENEERW GADLERHTDQ LDGLLADHAL
     LLNDLKLRQE PDNVKHWLDR VELFDKAASK ASVYADAIAS INYKSQTVPG QLGTLWWQYA
     QLYIDDGQYE TAKTILDKAL NVPYNFLQDP ELIWTKWAEE ELKRAGLDAA MQVLSHALQI
     PDDHELLRDK FESHEKMPAQ TVIFSSLKLW SFYIDLLEAS SESDEHLERT KAAYEATIQL
     KIATPLLFVN YAHYLQDKGN HVESFSIYER AVDIFPAETA FEIWDIYIGE ALKYGLPKEQ
     IRDLFESSLK MANEGVECKP FFLLYAKFER DNGMIETAAN ILHRACRAAQ TMDAKRSLWT
     LCLNWCRQEL GGSYARALYE ECIQALPNHV AVVYVLEYAK VEEGLKQVKR ARALLQYGAR
     LLHPANNADL WEYWELFELR HGNKDTYKDM LQLKRKVEEL LEGDGLPVPN QIGNIAFVAS
     TDGLQNPGGE STNINNDELE LDM