SYF1_ASPFU
ID SYF1_ASPFU Reviewed; 839 AA.
AC Q4WVF4;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Pre-mRNA-splicing factor syf1;
GN Name=syf1; ORFNames=AFUA_5G11910;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR EMBL; AAHF01000003; EAL91422.1; -; Genomic_DNA.
DR RefSeq; XP_753460.1; XM_748367.1.
DR AlphaFoldDB; Q4WVF4; -.
DR SMR; Q4WVF4; -.
DR STRING; 746128.CADAFUBP00005820; -.
DR EnsemblFungi; EAL91422; EAL91422; AFUA_5G11910.
DR GeneID; 3511486; -.
DR KEGG; afm:AFUA_5G11910; -.
DR eggNOG; KOG2047; Eukaryota.
DR HOGENOM; CLU_007736_0_0_1; -.
DR InParanoid; Q4WVF4; -.
DR OMA; FLMQQPL; -.
DR OrthoDB; 370051at2759; -.
DR Proteomes; UP000002530; Chromosome 5.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11246; PTHR11246; 1.
DR SMART; SM00386; HAT; 11.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome.
FT CHAIN 1..839
FT /note="Pre-mRNA-splicing factor syf1"
FT /id="PRO_0000205726"
FT REPEAT 12..44
FT /note="HAT 1"
FT REPEAT 46..78
FT /note="HAT 2"
FT REPEAT 90..122
FT /note="HAT 3"
FT REPEAT 124..158
FT /note="HAT 4"
FT REPEAT 274..309
FT /note="HAT 5"
FT REPEAT 377..415
FT /note="HAT 6"
FT REPEAT 417..453
FT /note="HAT 7"
FT REPEAT 470..502
FT /note="HAT 8"
FT REPEAT 507..539
FT /note="HAT 9"
FT REPEAT 541..575
FT /note="HAT 10"
FT REPEAT 578..612
FT /note="HAT 11"
FT REPEAT 650..684
FT /note="HAT 12"
FT REPEAT 686..720
FT /note="HAT 13"
FT REGION 758..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..820
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 839 AA; 97187 MW; B59A735A97F6F52A CRC64;
MDRTAASRPD LYLIADQDTV YEQDLFRAPG SIKPWLAYIE YKQQNGTLYE QAFVMERACK
QLPRSYKLWK MYLEFRINHL RGRNATKYRA EYQKVNALFE RALILLNKMP KIWEMYLSFL
LQQPLVTQTR RTFDRALRAL PITQHNRIWK LYKAFARSAS GQTAVKIWAR YMQIHPENAE
DYIELLVELG QYTEAVKRYM EILDDPRFQS KKGKSNFQLW TEMVDLLVSK AKQIRTGPQV
GIDVDAILRS GIDRFADQRG KLWAGLATYW ITKGNFEKAR DVFEEGITTV MTVRDFTLIF
DAYVEFEESI IGSLMEAAAV RADKGNVDED ADFDLDLRML RFEQLMDRRP FLVNDVLLRQ
NPNNVIEWEK RVALWGDNKE EIVNTYTAAI AAINPKKAHG KFSELWVNYA KFYESGGDLD
TARVIFDKAV KVPFKSVAEL ADTWCEWAEM ELRSENFDKA VDIMAKATQA PKKSTVDYFD
ETLSPQQRVH KSWKLWSFYV DLVESVATLE ETRKVYERIF ELRIATPQTV VNYANLLEEH
KYFEDSFKVY ERGLDLFSYP VAFELWNLYL TKAVDRKIGI ERLRDLFEQA LDGCPPKFAK
PLYLMYGNLE EERGLARHAM RIYERATRAV SDEDRFEMFE FYITKSASNF GLTSTRPIYE
RAIAALPDQE AKEMCLKFAD MERRLGEIDR ARAIYGHASQ FCDPRTNAGF WQKWEAFEVQ
HGNEDTFKEM LRIKRSVQAQ YNTDVNFIAS QAIARSQQRA QEGAREREGE EAGTDASKER
ADAMAALERQ ARAPIGFVAA STGPEGGNRP PPPGQQQQPQ PSAPVNPDAI DLDDDMDAE
